Prodigiosin inhibits proliferation and induces apoptosis through influencing amino acid metabolism in multiple myeloma.

The recurrence of drug-resistant and expensive treatment drugs are major causes of the low survival rate of multiple myeloma (MM) patients. Exploring a safe, effective, low-cost and novel drug treatment for MM is a promising strategy to relieve the burden of MM patients. In this study, we found that prodigiosin could inhibit MM cell proliferation and induce MM cell apoptosis, however, it had a lesser cytotoxic effect on normal B cells within the IC range of MM cells.

Novel method to measure track irregularity based on multiple MEMS-IMU and geometric constraint.

The track regularity with high accuracy is crucial important to protect the dynamic safety in high speed and heavy haul railways, normally, the inertial measurement unit (IMU)is capable to provide the precise solution for track irregularity measurement. However, to achieve high accuracy, the most existing track irregularity measurement methods seriously depended on the fiber-optic IMU, it is very expensive, also with larger size and weight, while the growing availability of low-cost and small size MEMS-IMU can yield acceptable accuracy for track irregularity by using multiple MEMS-IMUs fusion and particular geometric constraints. For these reasons, this paper proposes an accurate measurement method for track irregularity that combines the multiple MEMS-IMUs and special geometric constraints, which can be obtained noticeable measuring performances compared with fiber-optic IMU.

Correction: Simulation of the resistance switching performance and synaptic behavior of TiO-based RRAM devices with CoFeO insertion layers.

Correction for 'Simulation of the resistance switching performance and synaptic behavior of TiO-based RRAM devices with CoFeO insertion layers' by Fei Yang , , 2024, , 6729-6738, https://doi.org/10.1039/D3NR05935A.

Electroacupuncture Neural Stimulation Mitigates Bladder Dysfunction and Mechanical Allodynia in Cyclophosphamide Induced Cystitis through Downregulation of the BDNF-TrkB Signaling Pathway.

Central sensitization plays a critical role in bladder pain syndrome/interstitial cystitis (BPS/IC). Electroacupuncture (EA) nerve stimulation therapy has been broadly acknowledged as an effective means of alleviating chronic pathological pain. However, it remains to be explored whether EA is effective in mitigating pain-sensitive symptoms of BPS/IC and the mechanisms involved.

Unveiling circulating targets in pancreatic cancer: Insights from proteogenomic evidence and clinical cohorts.

Pancreatic cancer (PC), characterized by the absence of effective biomarkers and therapies, remains highly fatal. Data regarding the correlations between PC risk and individual plasma proteome known for minimally invasive biomarkers are scarce. Here, we analyzed 1,345 human plasma proteins using proteome-wide association studies, identifying 78 proteins significantly associated with PC risk.

Acute necrotizing encephalopathy in an adult presenting with typical imaging findings and distinctive cerebrospinal fluid characteristics: a case report.

Background: Acute necrotizing encephalopathy is a rare, clinically distinct subgroup of acute encephalopathy, which may be a complication of coronavirus disease 2019.

Case Presentation: A 22-year-old male of Han Chinese with a yellow complexion presented with fever, psychological and behavioral abnormalities, seizures, and coma. Cerebrospinal fluid tests indicated leukocytosis, high protein concentrations, and significantly elevated levels of neuron-specific enolase, interleukin-2, interleukin-6, and interleukin-8.

Room-Temperature Lasing of Sn-Based Perovskite Single-Crystal Microsquare Plates (MSPs).

Lead-free Sn-based metal halide perovskites are low-cost, high-efficiency photoelectric materials with significant potential for micro/nanolasers, addressing the biological and environmental toxicity of lead. This study explores the lasing behavior of single-crystal CsSnBr microsquare plates (MSPs) synthesized via two-step high-temperature vapor-phase epitaxy with steady-state and time-resolved photoluminescence (PL and TRPL) spectroscopies. The lasing behavior, dominated by excitons from 193 to 313 K, shows a lasing threshold of 122.

Longitudinal cross-lagged association between posttraumatic stress disorder, post-traumatic growth, and deliberate rumination among healthcare staff 2 years after the COVID-19 pandemic in Hubei Province, China.

Background: Post-traumatic stress disorder (PTSD) and post-traumatic growth (PTG) are inspiratory areas of psychological research in which deliberate rumination has important implications. However, these relationships have not yet been assessed in the COVID-19 pandemic using longitudinal designs.

Methods: In this study, measures of PTSD, PTG, and deliberate rumination were collected from 2,292 healthcare staff members at two-time points six months apart in 2022-2023 from two general hospitals in Hubei Province, China.

A review on As-contaminated soil remediation using waste biomass feedstock-based biochar and metal-modified biochar.

Arsenic (As) is a carcinogen that threatens ecosystems and human health. Due to its high adsorption, and microporosity, biochar is widely available for soil remediation. This review significantly summarizes the current status of waste biomass feedstock-based biochar and metal-modified biochar for As-contaminated soil remediation.

ERA5-SH: A global grided scale height dataset for tropospheric parameters based on ERA5 reanalysis.

The scale height (SH) represents the height increment for a certain parameter to decrease to 36.7% (1/e) of its value at a certain height. Here we present ERA5-SH, a gridded dataset containing the SH values of six troposphere key parameters (PWV, WVD, T, ZTD, ZHD and ZWD) based on ERA5 reanalysis from 2013 to 2022, with a temporal resolution of 1 hour and a spatial resolution of 1°.

Urinary biomarkers of drinking water disinfection byproducts in relation to blood-based liver function parameters among reproductive-aged Chinese women.

Background: Toxicological studies have documented that disinfection byproducts (DBPs), the ubiquitous drinking water pollutants, induce hepatotoxicity. Yet epidemiological evidence is sparse.

Objective: To assess urinary biomarkers of drinking water DBPs in relation to liver function parameters.

Deep Face Leakage: Inverting High-Quality Faces From Gradients Using Residual Optimization.

Collaborative learning has gained significant traction for training deep learning models without sharing the original data of participants, particularly when dealing with sensitive data such as facial images. However, current gradient inversion attacks are employed to progressively reconstruct private data from gradients, and they have shown successful in extracting private training data. Nonetheless, our observations reveal that these methods exhibit suboptimal performance in face reconstruction and result in the loss of numerous facial details.

Novel drug targets for monkeypox: From viral to host proteins.

Background: The ongoing threat of the monkeypox virus (MPXV) underscores the need for new antiviral treatments, yet drug targets and candidate therapies are limited.

Methods: Calculating the centrality, conservation, and immunogenicity of MPXV proteins in the network to identify viral drug targets. Constructing the MIP-human protein interaction network and identifying key human proteins as potential drug targets through network topology analysis.

Hierarchical Deformation Mechanisms and Energy Absorption in Bioinspired Thin-Walled Structures.

Lightweight, hierarchical thin-walled tubes are essential in aerospace and transportation for their exceptional impact resistance and energy absorption capabilities. This study applies bionic design principles to revolutionize traditional thin-walled tube structures, enhancing their energy absorption performance. Inspired by natural models-spider webs, beetle elytra, cuttlebone, and spiral wood fibers-integrated bionic hierarchical thin-walled tubes (IBHTTs) with diverse bionic structural and material combinations are developed using additive manufacturing.

Association between oral health and physio-cognitive decline syndrome of older adults in China and its sex differences: a cross-sectional study.

Background: Physio-Cognitive Decline Syndrome (PCDs) is characterized by the coexistence of MIND (mobility impairment, no disability) and CIND (cognitive impairment, no dementia), which predicts dementia risk. Deteriorating oral health can contribute to malnutrition, cognitive decline, and physical frailty, all of which may exacerbate PCDs symptoms. This study investigates the association between oral health and PCDs, exploring sex differences in this relationship.

Ant-Inspired Ion Gel Sensor for Dual-Mode Detection of Force and Humidity via Magnetic Induction.

In the realm of intelligent sensing, the development of multifunctional, highly sensitive, wide-ranging, and durable flexible sensors remains a formidable challenge. This paper introduces a dual-mode ionic gel sensor, inspired by the sensory mechanisms of ants and developed through magnetically induced technology capable of simultaneously detecting environmental humidity and pressure. The humidity sensor is fabricated from a prestretched, buckled poly(vinyl alcohol) (PVA) ionic gel with microstructures, exhibiting rapid response and high durability.

Selective impact of lignin and hemicelluloses macromolecules in bamboo cell walls by mildew.

Understanding the impact of mildew on lignin and hemicelluloses within plant cell walls is crucial for addressing biomass degradation and antimicrobial studies. In this work, Two-dimensional nuclear magnetic resonance (2D NMR) and nanoindentation techniques were used to characterize the effects of three mildew species-Aspergillus niger (AN), Trichoderma viride (TV), and Penicillium citrinum (PC)-on lignin and hemicelluloses within bamboo cell walls. 2D NMR detected bond changes, while nanoindentation measured mechanical decline.

ADFQ-ViT: Activation-Distribution-Friendly post-training Quantization for Vision Transformers.

Vision Transformers (ViTs) have exhibited exceptional performance across diverse computer vision tasks, while their substantial parameter size incurs significantly increased memory and computational demands, impeding effective inference on resource-constrained devices. Quantization has emerged as a promising solution to mitigate these challenges, yet existing methods still suffer from significant accuracy loss at low-bit. We attribute this issue to the distinctive distributions of post-LayerNorm and post-GELU activations within ViTs, rendering conventional hardware-friendly quantizers ineffective, particularly in low-bit scenarios.

The Noncanonical Wnt5a-Ca Pathway Mediates Mitochondrial Dysfunction in the Progression of Diabetic Nephropathy via the Mitochondrial Calcium Uniporter.

Abnormal Wnt5a expression, mitochondrial abnormalities and calcium overload have been detected in many metabolic diseases. However, the association of Wnt5a-Ca and mitochondrial dysfunction in diabetic nephropathy (DN) progression remains unknown. We used streptozotocin-induced DBA2/J male mice as a DN model.

Alteration in Tracheal Morphology and Transcriptomic Features in Calves After Infection with .

is one of the most important pathogens in animal husbandry, and the current infection and morbidity rates are increasing year by year, causing great losses to the farming industry and seriously affecting animal welfare. In this study, we took tracheal tissues from calves infected with to make pathological tissue sections for observation, and selected tracheal tissues for transcriptome sequencing to screen differentially expressed genes based on the threshold |log2FoldChange| > 1 and Padjust < 0.05 and functional enrichment, to explore in depth the potential mechanisms of bovine tracheal damage caused by bovine tracheitis.

Landscape of Noncoding RNA in the Hypoxic Tumor Microenvironment.

Amidst the prevalent and notable characteristic of a hypoxic microenvironment present in the majority of solid tumors, a burgeoning number of studies have revealed the significance of noncoding RNAs (ncRNAs) in hypoxic tumor regions. The transcriptome of cancers is highly heterogeneous, with noncoding transcripts playing crucial roles. Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are two distinctive classes of ncRNA that are garnering increasing attention.

Correction: Tan et al. Astaxanthin Alleviates Hepatic Lipid Metabolic Dysregulation Induced by Microcystin-LR. 2024, , 401.

The authors wish to make the following corrections to this paper [...

Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis.

Introduction: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of motor neurons (MNs). Genetic mutations in Optineurin (OPTN) and Superoxide Dismutase 1 (SOD1) have been identified as causal factors for ALS. OPTN immunopositive inclusions have been confirmed in the cases of ALS with SOD1 mutations.

Comparison of keratometry assessment between IOLMaster and Pentacam in dry eyes.

Background: To compare the keratometry measurements between IOLMaster and Pentacam in dry eyes.

Methods: A total of 122 eyes of 95 age-related cataract patients with dry eye disease were enrolled in this study. Keratometry measurements including flat and steep keratometry (K), mean keratometry, axis of the flat K, astigmatism of anterior corneal surface (A-ACS) were obtained using IOLMaster and Pentacam.

Collagen remodeling-mediated signaling pathways and their impact on tumor therapy.

In addition to their traditional roles in maintaining tissue morphology and organ development, emerging evidence suggests that collagen (COL) remodeling-referring to dynamic changes in the quantity, stiffness, arrangements, cleavage states, and homo-/hetero-trimerization of COLs-serves as a key signaling mechanism that governs tumor growth and metastasis. COL receptors act as switches, linking various forms of COL remodeling to different cell types during cancer progression, including cancer cells, immune cells, and cancer-associated fibroblasts (CAFs). In this review, we summarize recent findings on the signaling pathways mediated by COL arrangement, cleavage, and trimerization states (both homo- and hetero-), as well as the roles of the primary COL receptors-integrin, DDR1/2, LAIR-1/2, MRC2, and GPVI-in cancer progression.