Baicalin Inhibits Coxsackievirus B3 Replication by Reducing Cellular Lipid Synthesis.

Baicalin is a flavonoid extracted from and shows a variety of biological activities as reducing lipids, diminishing inflammation, and inhibiting bacterial infection. However, there is no report of baicalin against CVB3 infection. In this study, we found that baicalin can reduce viral titer in a dose-dependent manner at a dose with no direct virucidal effect.

Ferromagnetic insulator CrGeTe as a modulator for generating near-infrared bright-dark soliton pairs.

Novel two-dimensional (2D)-materials-based ultra-fast modulators exhibit significance in extending the fundamental investigations and practical applications of mode-locked fiber lasers. In our work, employing the liquid-phase exfoliation method, a ${{\rm Cr}_2}{{\rm Ge}_2}{{\rm Te}_6}$CrGeTe (CGT) optical modulator with a modulation depth and a saturable intensity of 1.64% and ${6.

Protective Effects of Fucoidan against Hydrogen Peroxide-Induced Oxidative Damage in Porcine Intestinal Epithelial Cells.

This study was conducted to evaluate the effectiveness of fucoidan in ameliorating hydrogen peroxide (HO)-induced oxidative stress to porcine intestinal epithelial cell line (IPEC-1). The cell viability test was initially performed to screen out appropriate concentrations of HO and fucoidan. After that, cells were exposed to HO in the presence or absence of pre-incubation with fucoidan.

Surface mineralized biphasic calcium phosphate ceramics loaded with urine-derived stem cells are effective in bone regeneration.

Background: Segmental bone defects caused by trauma, tumors, or infection are a serious challenge for orthopedists in the world. Recent developments in tissue engineering have provided a new treatment for segmental bone defects. Urine-derived stem cells (USCs) can be obtained noninvasively and might be a new kind of seed cells used in bone tissue regeneration.

A sensitive, wide-ranging comprehensive toxicity indicator based on microbial fuel cell.

An innovative indicator for toxicity detection based on microbial fuel cells, average current inhibition rate (ACIR) was proposed. It was applied to the toxicity evaluation of three typical specific pollutants in petrochemical wastewater including copper(II), 2,4-dichlorophenol (2,4-DCP) and pyridine. ACIR which considered the entire process of toxic effects was proved to be more sensitive and wide-ranging than the conventional indicators.

The introduction of benzimidazole and ether moieties into poly(-phenylene terephthalamide): effects on its microstructure, interactions and properties.

Co-poly(-phenylene terephthalamide) (co-PPTA) fibers containing 4,4'-oxidianiline (4,4'-ODA) and 2-(4-aminophenyl)-5-aminobenzimidazole (BIA) in terephthaloyl chloride (TPC) and -phenylene diamine (-PDA) were prepared a wet spinning method, followed by water washing and drawing at a high temperature. With the addition of a new acid-binding agent, imidazole, the solution prepared by low-temperature polycondensation had suitable viscosity for spinning. Herein, the properties of six co-PPTA fibers with different contents of BIA and 4,4'-ODA segments were studied.

Effects of pulsed electromagnetic field therapy on pain, stiffness and physical function in patients with knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.

Objective: To evaluate the efficacy of classical pulsed electromagnetic field therapy on patients with knee osteoarthritis.

Methods: The databases PubMed, EMBASE, Web of Science and Cochrane Library were searched for relevant studies. Randomized controlled trials comparing classical pulsed electromagnetic field with placebo for patients with knee osteoarthritis were included.

MZF1 in the Dorsal Root Ganglia Contributes to the Development and Maintenance of Neuropathic Pain via Regulation of TRPV1.

Previous studies have demonstrated that myeloid zinc finger 1 (MZF1) in the dorsal root ganglion (DRG) participates in neuropathic pain induced by chronic-constriction injury (CCI) via regulation of voltage-gated K channels (Kv). Emerging evidence indicates that transient receptor potential vanilloid 1 (TRPV1) is involved in the development and maintenance of neuropathic pain. Although it is known that the transcription of TRPV1 is regulated by Kruppel-like zinc-finger transcription factor 7 (Klf7)-and that the structure of TRPV1 is similar to that of Kv-few studies have systematically investigated the relationship between MZF1 and TRPV1 in neuropathic pain.

Characteristics and prognosis of pelvic Ewing sarcoma: a SEER population-based study.

Background: The pelvis is one of the primary sites of Ewing sarcoma (ES) and is associated with poorer prognoses than the extremities. Due to the rarity of this disease and limited data available, the prognostic factors of pelvic ES remain controversial. Thus, this study aimed to identify independent prognostic factors, and develop a nomogram for predicting survival rates in patients with pelvic ES.

Bioinspired glycosaminoglycan hydrogels via click chemistry for 3D dynamic cell encapsulation.

Cell encapsulation within 3D hydrogels is an attractive approach to develop effective cell-based therapies. However, little is known about how cells respond to the dynamic microenvironment resulting from hydrogel gelation-based cell encapsulation. Here, a tunable biomimetic hydrogel system that possesses alterable gelation kinetics and biologically relevant matrix stiffness is developed to study 3D dynamic cellular responses during encapsulation.

A quantitative evaluation method for wastewater toxicity based on a microbial fuel cell.

A microbial fuel cell (MFC) was successfully developed as a toxicity biomonitoring system to enable a quick response to wastewater with unknown toxicity in toxic events. The objective was to quantitatively assess the toxicity of wastewater by a rapid method. Different concentrations of formaldehyde were introduced into the anode chamber, which led to different stages of voltage change.

Broadband nonlinear absorption properties of two-dimensional hexagonal tellurene nanosheets.

Two dimensional (2D) Group-VI Te, tellurene, was successfully exfoliated using a liquid phase exfoliation (LPE) method. The prepared tellurene nanosheets possessed a thickness of 4.3-4.

Multimorphological top-hat-based multiscale target classification algorithm for real-time image processing.

The traditional top-hat method is a commonly used method that quickly separates targets from a background. It is used for its fast processing speed and wide range of applications on programmable hardware. However, in some important fields such as microfluidic control, medicine, aerospace, and optical measurement, the observed targets are often spotted with different sizes.

Clinical Evidence for Treatment of Distal Tibiofibular Syndesmosis Injury: A Systematic Review of Clinical Studies.

No consensus had been reached about the optimal treatment for syndesmotic fixation. We performed a review of randomized controlled trials (RCTs) to assist in clarifying many of the controversies that were debated for years despite new technology and options. PubMed, Embase, and the Cochrane Library were searched through specific terms and limits.

TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment.

Mechanisms for breast cancer metastasis remain unclear. Whether truncated glioma-associated oncogene homolog 1 (TGLI1), a transcription factor known to promote angiogenesis, migration and invasion, plays any role in metastasis of any tumor type has never been investigated. In this study, results of two mouse models of breast cancer metastasis showed that ectopic expression of TGLI1, but not GLI1, promoted preferential metastasis to the brain.

CMOS imager non-uniformity response correction-based high-accuracy spot target localization.

High-accuracy spot target detection based on a complementary metal-oxide semiconductor (CMOS) image sensor, such as astronomy magnitude, medicine, and astronomy photometrics, needs accurate pixel response. Because pixels have different silicon structures and read outputting, each pixel has non-uniformity response with specific illumination. The flat-field correction of a CMOS image sensor is crucial before image processing.

Investigation and development of maize fused network analysis with multi-omics.

Maize is a critically important staple crop in the whole world, which has contributed to both economic security and food in planting areas. The main target for researchers and breeding is the improvement of maize quality and yield. The use of computational biology methods combined with multi-omics for selecting biomolecules of interest for maize breeding has been receiving more attention.

Ultrasensitive Optical Detection of Water Pressure in Microfluidics Using Smart Reduced Graphene Oxide Glass.

Despite recent progresses in the field of microfluidics, the effect of liquid pressure on the detection accuracy has been rarely studied. Here, we perform a quantitative analysis of such effect, by utilizing the sensitive optical responses of graphene to the refractive index (RI) change of its surrounding environment. We utilize a reflection coupling configuration by combining the total internal reflection (TIR) and ultrasonic waves.

Investigating Maize Yield-Related Genes in Multiple Omics Interaction Network Data.

Zea mays (maize) is the highest yielding food crop globally, feeding large numbers of people across the planet. It is thus especially important to explore the key genes that affect maize production with prior knowledge. Merging multiple datasets of different types can improve the accuracy of candidate genes prediction results, so we constructed interaction networks using gene, mRNA, protein, and expression profile datasets.

Ca and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF.

Background: Brain metastases are a major cause of death in patients with metastatic breast cancer. While surgical resection and radiation therapy are effective treatment modalities, the majority of patients will succumb from disease progression. We have developed a novel therapy for brain metastases that delivers athermal radiofrequency electromagnetic fields that are amplitude-modulated at breast cancer specific frequencies (BCF).

Graphene Optical Biosensors.

Graphene shows great potential in biosensing owing to its extraordinary optical, electrical and physical properties. In particular, graphene possesses unique optical properties, such as broadband and tunable absorption, and strong polarization-dependent effects. This lays a foundation for building graphene-based optical sensors.

Upregulation of matrix metalloproteinase-9/2 in the wounded tissue, dorsal root ganglia, and spinal cord is involved in the development of postoperative pain.

Emerging evidence implicates the upregulation of matrix metalloproteinase (MMP)-9/2 in the dorsal root ganglion (DRG) and spinal cord as a contributor to the pathogenesis of chronic pain. In the current study, the expression of MMP-9/2 in wounded tissue, ipsilateral DRG, and the spinal dorsal horn as well as its role in the development of postoperative pain were examined following plantar incision in rats. Our results showed that plantar incision resulted in increased expression of MMP-9/2 in wounded tissue and ipsilateral L4/5 DRGs.

Efficacy and tolerability of duloxetine in patients with knee osteoarthritis: a meta-analysis of randomised controlled trials.

Background: Knee osteoarthritis (OA) is one of the most common joint diseases, and pharmacotherapy is necessary to control its symptoms.

Aim: To evaluate efficacy and tolerability of duloxetine in patients with knee OA.

Methods: PubMed, Web of Science, Embase, Cochrane Library and ClinicalTrials.