Occurrence of macroprolactinemia in schizophrenia patients treated with risperidone or amisulpride.

Objective: To investigate macroprolactinemia caused by antipsychotics and its clinical significance.

Methods: A total of 133 patients with schizophrenia were selected, all of whom were treated with either risperidone or amisulpride alone. The levels of total prolactin (T-PRL) and macroprolactin (MPRL) were measured before treatment as well as the second, fourth, and sixth weeks of treatment.

Risk factors for medication-induced amenorrhea in first-episode female Chinese patients with schizophrenia treated with risperidone.

Background: Amenorrhea is a common adverse effect of treatment with antipsychotic medications that influences both fertility and adherence to medication regimens. Most research suggests that medication-induced prolactinemia is the main cause of amenorrhea but few prospective studies have assessed this hypothesis.

Aim: Identify risk factors for amenorrhea following treatment with antipsychotic medication.