Production of cordycepin and mycelia by submerged fermentation of Cordyceps militaris in mixture natural culture.

The submerged fermentation of Cordyceps militaris for cordycepin production and mycelial growth was investigated in this study. Three natural materials of brown rice paste (BRP), beerwort (B), and soybean meal juice (SMJ) were used for fermentation of C. militaris in shaking flasks.

Early-phase endotoxic shock-induced myocardial injury increases iNOS and selectin expression in macaque primate.

Background: Our previous study has established a macaque model with early-phase endotoxic shock. The present study further investigated myocardial and blood vessel injury in Macaques by examining the subsequent expression of ACP, selectins, iNOS, and cTnI in response to LPS treatment.

Methods: In an experiment with anaesthetised, instrumental macaques, eleven animals were randomised into: an En group (n=6), receiving a dose of 2.

Effect of fluid resuscitation on ryanodine receptor in macaques with endotoxic shock.

Objective: Our recent study demonstrated that sodium bicarbonate improved cardiac function in macaque models with early-phase endotoxic shock. In the present study, we investigated further the ryanodine receptor/calcium release-channel (RyR) and calcium pump after fluid resuscitation of macaques with early-phase endotoxic shock.

Methods: Twenty-four anaesthetised macaques were assigned to four groups.