Publications by authors named "Fei Liao"
Helicobacter pylori (H. pylori) is one of the most globally prevalent bacteria, closely associated with gastrointestinal diseases such as gastric ulcers and chronic gastritis. Current clinical methods primarily involve Carbon-13 and Carbon-14 urea breath test, both carrying potential safety risks.
View Article and Find Full Text PDFBackground: The clinical efficacies of Ulcerative colitis (UC) are far from satisfactory. Fucoxanthin (FUC) is a marine carotenoid that is abundant in seaweed and microalgae. It has been reported that FUC can possess anti-inflammatory and antioxidant.
View Article and Find Full Text PDFA Patch-Based Method for Underwater Image Enhancement With Denoising Diffusion Models.
IEEE Trans Cybern
October 2024
The enhancement of underwater images has emerged as a significant technological challenge in advancing marine research and exploration tasks. Due to the scattering of suspended particles and absorption of light in underwater environments, underwater images tend to present blurriness and predominantly color distortion. In this study, we propose a novel approach utilizing denoising diffusion models to improve underwater degraded images.
View Article and Find Full Text PDFTaking the endophytic fungus UJ3-2, isolated from , as the experimental material, this study aimed to explore the composition of its metabolites and the underlying mechanisms by which it inhibits . Initially, the MIC, MBC, inhibitory curves, biofilm growth, and extracellular nucleic acids and proteins of S. aureus in response to the metabolites were measured.
View Article and Find Full Text PDFArticle Synopsis
- Young-onset colorectal cancer (YOCRC), affecting those under 50, is increasingly common globally, but current screening tests like the fecal immunochemical test are not very effective.
- Researchers analyzed clinical data from 10,874 young individuals to develop machine learning models that can identify those at high risk for YOCRC, leading to the need for colonoscopy.
- The Random Forest machine learning model showed strong performance in both internal and external testing, with high accuracy and recall rates, suggesting it could be an effective tool for risk assessment in YOCRC patients.
Article Synopsis
- Oxidative stress is a major factor in age-related macular degeneration (AMD), and autophagy helps combat this stress.
- Researchers found that oxidative stressors reduced the levels of LAMTOR1 in retinal pigment epithelium (RPE) cells from humans and mice, indicating a potential adaptive response.
- The study also revealed that Nrf2 enhances the transcription of LAMTOR1 via histone acetylation, suggesting that LAMTOR1 plays a significant role in the damage caused by oxidative stress in AMD.
Advances in multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer starvation therapy.
Expert Rev Mol Med
October 2024
Article Synopsis
- * Advances in nanotechnology, specifically using multifunctional metal-organic frameworks (MOFs), show promise in improving cancer treatment due to their customizable features and strong compatibility with biological systems.
- * This paper reviews the latest developments in MOF-based nanoplatforms for cancer starvation therapy, highlighting both their successes and the potential challenges in their implementation.
Article Synopsis
- The study aimed to create a machine learning tool to identify IBD patients at a higher risk of impaired quality of life (QOL), enabling earlier intervention and better long-term outcomes.* -
- Researchers collected data from 2478 IBD patients through an online questionnaire across multiple hospitals in China and developed eight machine learning models to predict QOL impairments.* -
- The support vector machine (SVM) model was found to be the most effective, highlighting key risk factors such as glucocorticoid use and anxiety, which are linked to poorer QOL.*
Recent studies confirmed that pyroptosis is involved in the progression of pulmonary hypertension (PH), which could promote pulmonary artery remodeling. Urolithin A (UA), an intestinal flora metabolite of ellagitannins (ETs) and ellagic acid (EA), has been proven to possess inhibitory effects on pyroptosis under various pathological conditions. However, its role on PH remained undetermined.
View Article and Find Full Text PDFObjective: To investigate the variability in the expression profile of genes associated with polymyositis (PM), explore the potential molecular mechanisms underlying PM, and predict novel targets for intervention.
Study Design: Descriptive study. Place and Duration of the Study: Department of Rheumatology, Taizhou Municipal Hospital, Taizhou, China, from August to November 2023.
Article Synopsis
- GPs need to evaluate significant bowel disease (SBD) in patients showing lower bowel symptoms, and this study focuses on the effectiveness of fecal immunochemical testing (FIT) for screening SBD.
- The study included a meta-analysis of 8,615 patients and calculated various diagnostic measures, showing FIT's sensitivity of 65% and specificity of 85% in detecting SBD.
- The findings suggest that while FIT is useful for ruling out SBD with a high negative predictive value, GPs should still refer patients to specialists when further assessment is needed.
Background: Extensive research has been conducted on the correlation between adipose tissue and the risk of malignant lymphoma. Despite numerous observational studies exploring this connection, uncertainty remains regarding a causal relationship between adipose tissue and malignant lymphoma.
Methods: The increase or decrease in adipose tissue was represented by the height of BMI.
Article Synopsis
- The study investigates the metabolic similarities and differences between patient-derived xenograft (PDX) tumors and the original primary cancer (PC) using pancreatic ductal adenocarcinoma as a model.
- Results showed that the first generation of PDX tumors (PDXG1) displayed significantly altered metabolite levels compared to the primary tumors, particularly in glycolysis and amino acid metabolism pathways.
- Overall, despite some changes over generations, PDX models retain more metabolic similarities to the primary tumors than cell-derived xenograft (CDX) models, making them more suitable for studying tumor metabolism.
Objective: We aimed to explore the geographic differences in psychological symptoms, sleep quality, and quality of life (QoL) among adult patients with inflammatory bowel disease (IBD).
Methods: A unified questionnaire was developed to collect data on psychological status and QoL of IBD patients from 42 hospitals across 22 provinces, municipalities, and autonomous regions in China's mainland from September 2021 to May 2022.
Results: A total of 2478 patients with IBD were surveyed.
Article Synopsis
- - The study investigates the effects of 2'-hydroxycinnamaldehyde (HCA) on ulcerative colitis (UC) and its mechanisms, noting current UC therapies are limited in effectiveness.
- - HCA was found to reduce inflammation and improve the health of intestinal cells in experimental models, showing that it reduces inflammatory cytokines and promotes tight junction protein expression.
- - The research concludes that HCA's benefits in treating UC are achieved by inhibiting the activation of STAT3, suggesting that targeting this pathway could be a new approach for managing UC effectively.
Article Synopsis
- Bone marrow-derived CD34-positive endothelial progenitor cells (EPCs) play a crucial role in compensatory lung growth (CLG), with microRNA (miR)-155 influencing their functions.
- Transfecting EPCs with miR-155 can enhance their proliferation, migration, and ability to form tubular structures, while blocking miR-155 has the opposite effect; JARID2 is a target of miR-155 that negatively regulates these processes.
- Transplanting EPCs treated with miR-155 into lung models significantly boosts lung volume and cell counts, but this effect is reversed when JARID2 is overexpressed, highlighting miR-155's role in promoting CLG through JAR
The impacts of minimally invasive esophagectomy (MIE) in comparison with open esophagectomy (OE) on postoperative complications, wound infections and hospital length of stay in patients with esophageal carcinoma (ESCA) using meta-analysis to provide reliable evidence for clinical practice. A search strategy was developed and computer searches were performed on Embase, Web of Science, PubMed, Cochrane Library, Wanfang, China Biomedical Literature Database and China National Knowledge Infrastructure databases for clinical studies that reported the effects of MIE in comparison with OE in patients with ESCA. The retrieval time was from their inception to October 2023.
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- A computer-aided diagnostic (CAD) system called ENDOANGEL-DBE was developed to automatically detect and classify small bowel abnormalities during double-balloon enteroscopy (DBE) to address the issue of false negatives due to human oversight or inexperience.
- The system was trained using over 8,000 images and evaluated against the performance of 8 endoscopists, showing a sensitivity of 92% and accuracy of 86% in classifying lesions.
- The CAD system outperformed novice endoscopists and matched the performance of experts, suggesting it could significantly assist clinicians in identifying small bowel diseases more accurately.
Article Synopsis
- Lifestyle changes are important for preventing and treating metabolic dysfunction-associated steatotic liver disease (MASLD), and the role of diet soft drinks in this context is unclear.
- This study used data from NHANES (2003-2006) to analyze the link between diet soft drink consumption and MASLD, using the Fatty Liver Index for assessment.
- Findings showed that high consumption of diet soft drinks is significantly linked to MASLD, with a considerable portion of this association being mediated by body mass index (BMI).
In veterinary medicine, natural products provide an alternative to chemical agents for mite management. In the present study, the acaricidal efficacy of leaf ethyl acetate extract against mites was examined. The chemical composition of the extract was determined using liquid chromatography-mass spectrometry (LC-MS) analysis.
View Article and Find Full Text PDFAgeratina adenophora (A. adenophora), one of the prominent invasive plants in the Asian continent has shown toxicity in animals. However, studies examining the gene expression and metabolic profiles of animals that ingest A.
View Article and Find Full Text PDFMites have been a persistent infectious disease affecting both humans and animals since ancient times. In veterinary clinics, the primary approach for treating and managing mite infestations has long been the use of chemical acaricides. However, the widespread use of these chemicals has resulted in significant problems, including drug resistance, drug residues, and environmental pollution, limiting their effectiveness.
View Article and Find Full Text PDFBackground: The choice of polypectomy device and surveillance intervals for colorectal polyps are primarily decided by polyp size. We developed a deep learning-based system (ENDOANGEL-CPS) to estimate colorectal polyp size in real time.
Methods: ENDOANGEL-CPS calculates polyp size by estimating the distance from the endoscope lens to the polyp using the parameters of the lens.