On-chip integrated optical stretching and electrorotation enabling single-cell biophysical analysis.

Cells have different intrinsic markers such as mechanical and electrical properties, which may be used as specific characteristics. Here, we present a microfluidic chip configured with two opposing optical fibers and four 3D electrodes for multiphysical parameter measurement. The chip leverages optical fibers to capture and stretch a single cell and uses 3D electrodes to achieve rotation of the single cell.

Application of the Willis Covered Stent in the treatment of intracranial unruptured aneurysms in internal carotid artery: A retrospective single-center experience.

The purpose of this study was to retrospectively analyse the clinical and angiographic outcomes of Willis covered stent placement for unruptured aneurysms in internal carotid artery. Forty-six consecutive patients with internal carotid artery aneurysms (49 cases) were included to evaluate clinical and angiographic outcomes. Covered stent placement was successful in 47 cases, whereas stent navigation failed in 2 cases.

The Electrical-Triggered High Contrast and Reversible Color-Changing Janus Fabric Based on Double Side Coating.

A sensitive electro-thermochromic Janus fabric driven by voltage is demonstrated via a facial double side coating. The graphene forms a conductive layer that allows Joule heating to supply the thermal resource for the electro-thermochromic behavior of polyester fabric. The thermochromic dye with reversible color-changing property is coated on the opposite side of the graphene layer.

Nonlinear organic-inorganic halide hybrids containing unprecedented linear [MIX] coordination units and quasi-two-dimensional lone pairs.

Organic-inorganic halide hybrids are rapidly gaining increased attention owing to their remarkable optoelectronic performance. Amongst these, divalent and trivalent metal cations (Pb2+, Sn2+, Bi3+, and Sb3+) usually link to six halogen X atoms and form an asymmetric [MX6] octahedron with weak optical anisotropy. Herein, we show a first family of monovalent-metal-based hybrid halides [N(CH3)4]MCl2 (M = Ga, In) with a zero-dimensional configuration containing unprecedented linear [MX2] units.

A Series of Organic-Inorganic Hybrid Compounds [(CH)N]InClBr ( = 0, 2, 4): Synthesis, Crystal Structure, and Nonlinear Optical Properties.

A series of noncentrosymmetric (NCS) tetraethylammonium tetrahalide indium hybrids, [(CH)N]InClBr ( = 0, 2, 4), was synthesized by a hydrothermal reaction. Their structures, thermal properties, and linear and nonlinear optical properties were identified. The crystals belong to an isomorphic hexagonal system and feature zero-dimensional structures containing isolated distorted InClBr tetrahedra with [N(CH)] cations inserted as charge balance.

Pushing periodic-disorder-induced phase matching into the deep-ultraviolet spectral region: theory and demonstration.

Nonlinear frequency conversion is a ubiquitous technique that is used to obtain broad-range lasers and supercontinuum coherent sources. The phase-matching condition (momentum conservation relation) is the key criterion but a challenging bottleneck in highly efficient conversion. Birefringent phase matching (BPM) and quasi-phase matching (QPM) are two feasible routes but are strongly limited in natural anisotropic crystals or ferroelectric crystals.

Flower-like cobalt carbide for efficient carbon dioxide conversion.

Catalytic conversion of carbon dioxide (CO) to value-added chemicals under mild conditions is highly desired, albeit with significant challenges. Here, in terms of exposure of abundant active sites and excellent photo-to-thermal conversion properties, flower-like CoC has been firstly used for effectively catalysing the cycloaddition of CO with epoxides to produce cyclic carbonates with yields of up to 95% under solar light. Density functional theory (DFT) calculations reveal that Lewis acid sites of the surface Co atoms can activate both CO and epoxide, thus opening up the possibility of a CO-epoxide cycloaddition reaction.

High-intensity interval training and moderate-intensity continuous training alleviate β-amyloid deposition by inhibiting NLRP3 inflammasome activation in APPswe/PS1dE9 mice.

Recent study has demonstrated that high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) have the same effect to alleviate β-amyloid pathology in the hippocampus of APPswe/PS1dE9 (APP/PS1) mice. Activation of nucleotide binding and oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is pivotal and has been demonstrated to accelerate β-amyloid accumulation. The present study aimed to examine whether the exercise-induced β-amyloid reduction was associated with changes in NLRP3 inflammasome activation.

A Transfer Learning-Based Multi-Instance Learning Method With Weak Labels.

In multi-instance learning (MIL), labels are associated with bags rather than the instances in the bag. Most of the previous MIL methods assume that each bag has the actual label in the training set. However, from the process of labeling work, the label of a bag is always evaluated by the calculation of the labels obtained from a number of labelers.

Data-driven prediction of diamond-like infrared nonlinear optical crystals with targeting performances.

Combining high-throughput screening and machine learning models is a rapidly developed direction for the exploration of novel optoelectronic functional materials. Here, we employ random forests regression (RFR) model to investigate the second harmonic generation (SHG) coefficients of nonlinear optical crystals with distinct diamond-like (DL) structures. 61 DL structures in Inorganic Crystallographic Structure Database (ICSD) are selected, and four distinctive descriptors, including band gap, electronegativity, group volume and bond flexibility, are used to model and predict second-order nonlinearity.

Highly Efficient Super-Continuum Generation on an Epsilon-Near-Zero Surface.

The efficient super-continuum (SC) generation on a surface via a high-order photo-electron interaction is a great challenge for integrated optics because the surficial nonlinear optical efficiency is usually limited by finite light-matter interaction length and electric field intensity. Nowadays, epsilon-near-zero (ENZ) materials, showing infinite enhanced electronic field in theory, provide a kind of new platform to obtain a giant nonlinear response on the surface. Here, under the irradiation of a multiwavelength laser, an exotic and efficient SC generation from 406 to 1100 nm on the ENZ aluminum-doped zinc oxide surface was experimentally demonstrated by diversified nonlinear processes, including second harmonic generation, third harmonic generation, four wavelength mixing, and cascading stimulated Raman scattering.

Lead-Free Tin(IV)-Based Organic-Inorganic Metal Halide Hybrids with Excellent Stability and Blue-Broadband Emission.

Lead-free zero-dimensional (0D) organic-inorganic metal halide hybrids have recently attracted special attention as luminescent materials. However, their structural stability is still a challenge for the further development. Here, we select Sn as the B-site inorganic cation and obtain a new tin(IV)-based organic-inorganic metal halide hybrids (CNHCl)SnCl with remarkable air stability.

Resibufogenin suppresses tumor growth and Warburg effect through regulating miR-143-3p/HK2 axis in breast cancer.

Increasing evidence confirmed that the Warburg effect plays an important role involved in the progression of malignant tumors. Resibufogenin (RES) has been proved to have a therapeutic effect in multiple malignant tumors. However, the mechanism of whether RES exerted an antitumor effect on breast cancer through regulating the Warburg effect is largely unknown.

Treatment of obstructive sleep apnea with CPAP improves chronic inflammation measured by neutrophil-to-lymphocyte ratio.

Study Objectives: Obstructive sleep apnea (OSA) is associated with chronic inflammation likely triggered by nocturnal, intermittent hypoxemia and increased adrenergic tone. The neutrophil-to-lymphocyte ratio (NLR) was recently described as a measure of subclinical systemic inflammation. Studies on the effect of continuous positive airway pressure (CPAP) therapy in OSA on subclinical inflammation measured by NLR are lacking.

Defect Engineering of MoS for Room-Temperature Terahertz Photodetection.

Two-dimensional (2D) materials have exotic intrinsic electronic band structures and are considered as revolutionary foundations for novel nanodevices. Band engineering of 2D materials may pave a new avenue to overcome numerous challenges in modern technologies, such as room temperature (RT) photodetection of light with photon energy below their band gaps. Here, we reported the pioneering RT MoS-based photodetection in the terahertz (THz) region via introducing Mo and S vacancies for rational band gap engineering.

On-chip simultaneous rotation of large-scale cells by acoustically oscillating bubble array.

Bubbles locating in microfluidic chamber can produce acoustic streaming vortices by applying travelling surface acoustic wave oscillation in an ultrasonic range, which can be used to drive bio-samples to move within the flow field. In this paper, a strategy of bubble array configured in a large number of regularly arranged horseshoe structures is proposed to capture and rotate cells simultaneously. By modifying the geometric parameters of the horseshoe structure and microfluidic setting, high bubble homogeneity and cell trapping percentage was achieved.

"Old dog, new tricks": the lone pair effect inducing divergent optical responses in lead cyanurates containing π-bonds.

The stereochemically active lone pair (SCALP) effect of Pb2+ plays a vital role in enhancing the nonlinear optical response and engineering the band gap of lead-based materials with intriguing properties. Herein, we combined SCALP Pb2+ cations and π-conjugated (HC3N3O3)2- anions into one structure to investigate the tunable optical properties. Two lead cyanurates, namely, Pb3(HC3N3O3)2(OH)2 (I) and its partly cadmium-substituted analog Pb2Cd(HC3N3O3)2(OH)2 (II) were grown by the mild hydrothermal method.

Highly integrated microfluidic device for cell pairing, fusion and culture.

In this study, we proposed a microfluidic device with compact structures integrating multiple modalities for cell capture, pairing, fusion, and culture. The microfluidic device is composed of upper and lower parts. The lower part configured with electrodes and capture wells is used for cell trapping/pairing/fusion, while the upper part configured with corresponding culture wells is used for cell culture.

Effect of Particle Sizes of Nickel Powder on Thermal Conductivity of Epoxy Resin-Based Composites under Magnetic Alignment.

Magnetically oriented three-phase composite systems of epoxy resin, aluminum nitride, and nickel have been prepared, the thermal conductivity of composites filled with nickel powder with different particle sizes and content under different applied magnetic fields was studied. The vibrating scanning magnetometer (VSM) and scanning electron microscopy (SEM) were applied to investigate the dispersion of nickel powder in the composites. The results showed that the anisotropic thermal conductivity of the composites treated by applied magnetic field forming chain structure is obtained.

Correction: Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice.

[This corrects the article DOI: 10.1371/journal.pone.

Surface Nonlinear Optics on Centrosymmetric Dirac Nodal-Line Semimetal ZrSiS.

Gapless surface states (SSs) are features of topological semimetals and are extensively observed. Nowadays, the emerging question is whether the SSs possess exotic and applicable properties. Here, associated with the symmetrical selection rule for nonlinear optical materials, the surface nonlinear optics on a centrosymmetric Dirac nodal-line semimetal ZrSiS crystal is studied and it is found that the SSs bring record nonlinear susceptibilities.

A Contact-Sliding-Triboelectrification-Driven Dynamic Optical Transmittance Modulator for Self-Powered Information Covering and Selective Visualization.

Triboelectrification-enabled self-powered flexible electronic/optical systems have aroused a new surge of interest in recent years. All-in-one integration of such a system, which could significantly improve its adaptability, operability, and portability, still remains a challenge due to the absence of suitable architectures and integration schemes. Herein, a previously reported self-powered optical switch (OS) is thoroughly remolded and upgraded to a fully integrated contact-sliding-triboelectrification-driven dynamic optical transmittance modulator (OTM).