Effect of sodium bicarbonate and sodium chloride on aggregation and conformation of pork myofibrillar protein.

To investigate the effect of sodium bicarbonate instead of sodium chloride, the changes in pH, turbidity, aggregation, and conformation of myofibrillar protein solution with various amounts of sodium chloride and sodium bicarbonate were studied. When the sodium bicarbonate was increased from 0% to 0.4%, accompanied by the sodium chloride being decreased from 2.

DDB2 regulates DNA replication through PCNA-independent degradation of CDT2.

Background: Targeting ubiquitin-dependent proteolysis is one of the strategies in cancer therapy. CRL and CRL are two key E3 ubiquitin ligases involved in DNA replication and DNA damage repair. But CDT2 and DDB2 are opposite prognostic factors in kinds of cancers, and the underlining mechanism needs to be elucidated.

Investigation of novel optical and waveguide characteristics for an air-graphene-LiNbOsystem.

The optical characteristics of a planar thin film waveguide system composed of air-graphene-LiNbOhave been investigated. Monolayer or bilayer graphene of high quality are characterized by Raman spectroscopy, scanning electron microscopy and atomic force microscopy. The refractivity and reflectivity of the air-graphene-LiNbOsystem are measured experimentally and compared with those of a LiNbOwaveguide by the prism coupling method.

Glucose-6-Phosphate Isomerase FgGPI, a β Tubulin-Interacting Protein, Is Indispensable for Fungal Development and Deoxynivalenol Biosynthesis in .

Glucose-6-phosphate isomerase (GPI) is ubiquitous in most organisms, catalyzing the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. In this study, we investigated biological and genetic functions of in the phytopathogen . We found that hyphal growth, conidial germination, and septa formation were significantly inhibited in deletion mutant ∆FgGPI.

Chronic stress promotes acute myeloid leukemia progression through HMGB1/NLRP3/IL-1β signaling pathway.

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with poor prognosis and overall survival. Clinical investigations show that chronic stress is commonly present in the course of AML and associated with adverse outcome. However, the underlying molecular mechanisms are elusive.

Coastal vulnerability to climate change in China's Bohai Economic Rim.

Climate change and human activities exert a wide range of stressors on urban coastal areas. Synthetical assessment of coastal vulnerability is crucial for effective interventions and long-term planning. However, there have been few studies based on integrative analyses of ecological and physical characteristics and socioeconomic conditions in urban coastal areas.

Wheat heat tolerance is impaired by heightened deletions in the distal end of 4AL chromosomal arm.

Heat stress (HS) causes substantial damages to worldwide crop production. As a cool season crop, wheat (Triticum aestivum) is sensitive to HS-induced damages. To support the genetic improvement of wheat HS tolerance (HST), we conducted fine mapping of TaHST1, a locus required for maintaining wheat vegetative and reproductive growth under elevated temperatures.

Polyoxometalate-Based Nanomaterials Toward Efficient Cancer Diagnosis and Therapy.

As an emerging class of inorganic metal oxides, organically functionalized polyoxometalates (POMs) or POM-based nanohybrids have been demonstrated promising potential for the inhibition of various cancer types by the virtue of their diversity in structures and significantly reduced toxicity. This contribution summarizes the latest achievement of POM-based nanomaterials in cancer diagnosis and various therapeutics to put forward our fundamental viewpoints on the design principles of modified POMs based on their application. In addition, major challenges and perspectives in this field are also discussed.

Data-Driven Model Reduction for Stochastic Burgers Equations.

We present a class of efficient parametric closure models for 1D stochastic Burgers equations. Casting it as statistical learning of the flow map, we derive the parametric form by representing the unresolved high wavenumber Fourier modes as functionals of the resolved variable's trajectory. The reduced models are nonlinear autoregression (NAR) time series models, with coefficients estimated from data by least squares.

Decreased expression of the long non-coding RNA promotes gastric cancer progression by targeting HOXD8 and activating PI3K/Akt signaling pathway.

Background: Long non-coding RNAs (lncRNAs) have been shown to be associated with many tumors. However, the specific mechanism of lncRNAs in the occurrence and development of gastric cancer (GC) has not been fully elucidated.

Aim: To explore the expression level and molecular mechanism of in GC tissues and cells, and analyze its significance in the prognosis of GC.

Facile immobilization of graphene nanosheets onto PBO fibers via MOF-mediated coagulation strategy: Multifunctional interface with self-healing and ultraviolet-resistance performance.

The surface of poly (p-phenylene benzobisoxazole) (PBO) fibers with self-healing and ultraviolet (UV)-resistance performance play the key role in prolonging their service lifespan. Although great advances have been made in the single aspect of above two properties, integration of self-healing and anti-UV performance into the surface of PBO fiber is still a challenge. In this study, the coagulation strategy mediated by metal-organic framework (MOF) is proposed to construct the multifunctional surface of PBO fibers.

Endovascular treatment with stenting of celiac artery aneurysms.

This study aimed to detail the clinical outcomes of patients suffering from celiac arterial aneurysm (CAA) that underwent treatment via stent occlusion.This is a single-center, retrospective study. A total of 8 consecutive CAA patients were treated via stent occlusion from March 2014 to September 2018 at our hospital.

Microtubule-assisted mechanism for toxisome assembly in Fusarium graminearum.

In Fusarium graminearum, a trichothecene biosynthetic complex known as the toxisome forms ovoid and spherical structures in the remodelled endoplasmic reticulum (ER) under mycotoxin-inducing conditions. Previous studies also demonstrated that disruption of actin and tubulin results in a significant decrease in deoxynivalenol (DON) biosynthesis in F. graminearum.

Rehabilitation Treatment of Motor Dysfunction Patients Based on Deep Learning Brain-Computer Interface Technology.

In recent years, brain-computer interface (BCI) is expected to solve the physiological and psychological needs of patients with motor dysfunction with great individual differences. However, the classification method based on feature extraction requires a lot of prior knowledge when extracting data features and lacks a good measurement standard, which makes the development of BCI. In particular, the development of a multi-classification brain-computer interface is facing a bottleneck.

Triticum population sequencing provides insights into wheat adaptation.

Bread wheat expanded its habitat from a core area of the Fertile Crescent to global environments within ~10,000 years. The genetic mechanisms of this remarkable evolutionary success are not well understood. By whole-genome sequencing of populations from 25 subspecies within the genera Triticum and Aegilops, we identified composite introgression from wild populations contributing to a substantial portion (4-32%) of the bread wheat genome, which increased the genetic diversity of bread wheat and allowed its divergent adaptation.

NLRP3 inflammasome upregulates PD-L1 expression and contributes to immune suppression in lymphoma.

The NLRP3 inflammasome plays a pro-tumorigenic role in various malignancies. However, its potential role in lymphomagenesis remains unclear. In this study, we identified an immunosuppressive state in patients with diffuse large B cell lymphoma (DLBCL), which was characterized by markedly elevated interleukin (IL)-18 levels in lymphoma tissues and positive correlation with programmed death ligand 1 (PD-L1) expression.

A Hybrid Procedure Combining Mini-Thoracotomy with Interventional Endocardial Lead Implantation for Cardiac Resynchronization Therapy in Patients with Chronic Congestive Heart Failure: A Report of Four Cases.

Background: We describe the application and effectiveness of transthoracic electrode implantation for epicardial left ventricular pacing in cardiac resynchronization therapy (CRT) for patients with chronic congestive heart failure.

Methods: We assessed four patients with chronic congestive heart failure for whom implantation of endocardial electrodes was contraindicated. The epicardial electrodes were implanted via a mini-thoracotomy in the fourth or fifth left intercostal space.

Does new instrument for Oxford unicompartmental knee arthroplasty improve short-term clinical outcome and component alignment? A meta-analysis.

Background: The Microplasty (MP) instrumentation designed for the Phase III Oxford mobile-bearing unicompartmental knee arthroplasty (UKA) system is considered a better option to achieve more accurate component positioning and alignment. In the present study, we focused on short-term clinical and radiological outcomes to determine whether the MP instrumentation can reduce the short-term revision rate and occurrence of outliers of metallic components.

Methods: The literature in PubMed, Embase, the Cochrane Library, and Web of Science was searched up to May 2020.

TNFAIP8 promotes AML chemoresistance by activating ERK signaling pathway through interaction with Rac1.

Background: Chemoresistance is emerging as a major barrier to successful treatment in acute myeloid leukemia (AML), and evasion of apoptosis is among the fundamental underlying mechanisms. Therefore, unraveling molecular networks that drive this process constitutes an urgent unmet need. Herein, we aim to characterize the role and molecular mechanism of the tumor necrosis factor ɑ-induced protein 8 (TNFAIP8), a novel anti-apoptotic molecule, in AML chemoresistance.

Brain Metabolisms Involved in Self-Reported Quality of Mobility in Parkinson's Disease.

Background: Objective motor ratings and subjective motor complaints are both widely used in Parkinson's disease (PD). However, the objective basis to the self-perceived mobility quality is still not well elucidated.

Purposes: We aimed to figure out the relevancy between the UPDRS motor scores and PDQ39 mobility sub-scores, and further explore whether physician-assessed motor dysfunctions and patients-reported mobility deficits have some shared mechanisms.

A portable point-of-care testing system to diagnose lung cancer through the detection of exosomal miRNA in urine and saliva.

A lung cancer diagnostic kit (LCDK) with the advantages of low cost, easy operation and high sensitivity for the rapid diagnosis of lung cancer was developed. The proposed LCDK is able to noninvasively discriminate lung cancer using clinical salivary and urine samples in a short period of time.

Engineering Platinum-Oxygen Dual Catalytic Sites via Charge Transfer towards Highly Efficient Hydrogen Evolution.

A dual-site catalyst allows for a synergetic reaction in the close proximity to enhance catalysis. It is highly desirable to create dual-site interfaces in single-atom system to maximize the effect. Herein, we report a cation-deficient electrostatic anchorage route to fabricate an atomically dispersed platinum-titania catalyst (Pt /Ti O ), which shows greatly enhanced hydrogen evolution activity, surpassing that of the commercial Pt/C catalyst in mass by a factor of 53.

Surgical Treatment of Coronary Pseudoaneurysm: A Case Report and Literature Review.

A coronary pseudoaneurysm is a rare complication of chest trauma. In this report, we describe the case of a 65-year-old man with a mediastinal lesion. On admission, he complained of chest tightness and dry cough, and a pseudoaneurysm was confirmed in the left anterior descending branch of the coronary artery on chest computerized tomography, angiography, and coronary angiography.

Quinone outside inhibitors affect DON biosynthesis, mitochondrial structure and toxisome formation in Fusarium graminearum.

Quinone outside inhibitors (QoIs) are currently extensively used agricultural fungicides. However, the application of QoIs in controlling Fusarium graminearum was rarely reported. No information is available on pharmacological characteristics of QoIs against F.