Publications by authors named "Fei Fei Duan"
KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2.
Sci China Life Sci
October 2022
Article Synopsis
- KLF17 is crucial for maintaining the naive pluripotent state of human embryonic stem cells (hESCs) and facilitates the transition from a primed to a naive state.
- Research identifies MAPK3 and ZIC2 as two transcriptional targets that KLF17 represses, which is key to its role in promoting naive pluripotency.
- The study implies that KLF17 is not only important for hESCs but also plays a significant role in early mouse embryo development, indicating conserved functions across species.
Article Synopsis
- Long noncoding RNAs (lncRNAs) are crucial in regulating gene networks in embryonic stem cells (ESCs), but their exact functions are still not fully understood.
- The study identifies Trincr1 lncRNA, which interacts with TRIM71 to modulate FGF/ERK signaling and ESC self-renewal by downregulating SHCBP1 protein.
- Disruption of Trincr1 leads to increased ERK activity and decreased self-renewal in ESCs, while reducing TRIM71 can reverse these effects, emphasizing the role of lncRNAs in cell signaling and fate specification.
MicroRNAs and RNA binding protein regulators of microRNAs in the control of pluripotency and reprogramming.
Curr Opin Genet Dev
October 2017
Article Synopsis
- Post-transcriptional and translational regulations are crucial for cellular reprogramming and maintaining pluripotent stem cells (PSCs), with microRNAs (miRNAs) playing significant roles in regulating cell cycle, survival, and pluripotency.
- Recent studies highlight miRNAs' involvement in transitioning between naive and primed pluripotent states, as well as the formation of totipotent-like cells.
- The interplay between RNA binding proteins (RBPs) and miRNAs is vital for understanding the regulatory mechanisms of pluripotency, which may enhance clinical applications of PSCs.
Attenuated (, LM) induces specific CD8 and CD4 T cell responses, and has been identified as a promising cancer vaccine vector. Cervical cancer is the third most common cancer in women worldwide, with human papillomavirus (HPV), particularly type 16, being the main etiological factor. The therapeutic HPV vaccines are urgently needed.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how microRNAs (miRNAs) affect the transition from naive to primed pluripotency in embryonic stem cells (ESCs).
- Researchers found that deleting Dgcr8 in ESCs hindered the silencing of naive pluripotency and the establishment of primed pluripotency during differentiation.
- A screening of miRNAs showed that the miR-290 and miR-302 clusters play key roles in silencing naive pluripotency and may promote this transition by enhancing the MEK pathway while repressing Akt1.