Genome-Wide Association Study on Imputed Genotypes of 180 Eurasian Soybean Varieties for Oil and Protein Contents in Seeds.

Soybean () is a leguminous plant with a broad range of applications, particularly in agriculture and food production, where its seed composition-especially oil and protein content-is highly valued. Improving these traits is a primary focus of soybean breeding programs. In this study, we conducted a genome-wide association study (GWAS) to identify genetic loci linked to oil and protein content in seeds, using imputed genotype data for 180 Eurasian soybean varieties and the novel "genotypic twins" approach.

Effect of Biopesticide Novochizol on Development of Stem Rust f. sp. in Wheat, L.

The use of biological plant protection products is promising for agriculture. In particular, chitosan-based biopesticides have become widespread for stimulating growth and protecting plants from a wide range of pathogens. Novochizol is a product obtained by intramolecular cross-linking of linear chitosan molecules and has a globular shape, which provides it with a number of advantages over chitosan.

[The analysis of need in medical care of elder able-bodied women with diseases of blood circulation system].

The purpose of the study is to analyze demand in medical care at diseases of circulatory system in women in age groups of 50-64 years old. The database of cases of medical care support of population age groups 50-64 years (the database of calls of Territorial Foundation of Mandatory Medical Insurance of the Moscow region) was used as primary information source. After correlation analysis of dependencies between indicators of demand in modeling, four indicators were left, three of them were volumetric and one frequency.

[The analysis of age dynamics of causes of mortality of population of elderly age groups as reserve of maintaining population of older able-bodied age].

The article analyzes age dynamics of initial causes of death according to records in medical death certificates of population of older age groups. Materials and methods. The records of causes of death of 34.

Identification of Novel Loci Precisely Modulating Pre-Harvest Sprouting Resistance and Red Color Components of the Seed Coat in L.

The association between pre-harvest sprouting (PHS) and seed coat color has long been recognized. Red-grained wheats generally exhibit greater PHS resistance compared to white-grained wheat, although variability in PHS resistance exists within red-grained varieties. Here, we conducted a genome-wide association study on a panel consisting of red-grained wheat varieties, aimed at uncovering genes that modulate PHS resistance and red color components of seed coat using digital image processing.

[The algorithm of planning the needs in medical care provided in out-patient conditions to elderly age groups of population using mathematical models].

The purpose of the study is to develop algorithm for planning the need in medical care provided in out-patient conditions to elderly groups of population based on mathematical modeling methods. Research materials and methods. As a source of information, data on cases of medical care provided to the population of elderly age groups (60 years and older) were used.

[The analysis of health condition of individuals aged 40 years and older and going in for sports].

The attitude to high physical loads on organism in the middle and older age groups is ambiguous, from optimistic to completely pessimistic, associated with possibility of development pathological processes because of high physical activity. The purpose of the study is to evaluate health status of people aged 40 years and older involved in sports. The health data was obtained through interviewing athletes aged 40 years and older competing in track and field events at distances of 10 kilometers or more.

[The dynamics of morbidity and mortality of malignant neoplasms of blood system а population of St. Petersburg].

The morbidity of hematologic malignant neoplasms increases all over the world, while mortality rate decreases slowly that causes significant economic losses in society due to blood system tumors. It also proves relevance of research of morbidity and mortality of these diseases both in the Russian Federation and certain regions. The goal of the research was to analyze dynamics of indicators of primary morbidity and mortality of hematologic malignant neoplasms among residents of St.

Minigene splicing assessment of 20 novel synonymous and intronic glucokinase gene variants identified in patients with maturity-onset diabetes of the young.

The next-generation sequencing (NGS) has become a routine method for diagnostics of inherited disorders. However, assessment of the discovered variants may be challenging, especially when they are not predicted to change the protein sequence. Here we performed a functional analysis of 20 novel or rare intronic and synonymous glucokinase (GCK) gene variants identified by targeted NGS in 1,130 patients with maturity-onset diabetes of the young.

The role of flavin-containing enzymes in mitochondrial membrane hyperpolarization and ROS production in respiring Saccharomyces cerevisiae cells under heat-shock conditions.

Heat shock is known to accelerate mitochondrial ROS production in Saccharomyces cerevisiae cells. But how yeast mitochondria produce ROS under heat-shock condition is not completely clear. Previously, it was shown that ROS production in heat-stressed fermenting yeast cells was accompanied by mitochondrial membrane potential (MMP) increase.

Relation between cell death progression, reactive oxygen species production and mitochondrial membrane potential in fermenting Saccharomyces cerevisiae cells under heat-shock conditions.

Moderate heat shock increased reactive oxygen species (ROS) production that led to cell death in glucose-grown Saccharomyces cerevisiae cells. Conditions that disturb mitochondrial functions such as treatment by uncouplers and petite mutation were shown to inhibit ROS production and protects cell from thermal death. Hence, mitochondria are responsible for ROS production and play an active role in cell death.

Heat shock induces production of reactive oxygen species and increases inner mitochondrial membrane potential in winter wheat cells.

Heat shock leads to oxidative stress. Excessive ROS (reactive oxygen species) accumulation could be responsible for expression of genes of heat-shock proteins or for cell death. It is known that in isolated mammalian mitochondria high protonic potential on the inner membrane actuates the production of ROS.

[Induction of Hsp104 synthesis in Saccharomyces cerevisiae is inhibited by the petite mutation in the stationary growth phase].

The elevation of Hsp104 (heat shock protein) content under heat shock plays a key role in yeast (Saccharomyces cerevisiae) cells. Hsp104 synthesis is increased under heat stress in the stationary growth phase. As shown, the loss of mitochondrial DNA (petite mutation) inhibited the induction of the Hsp104 synthesis under heat stress (39 degrees C) during the transition to the stationary growth phase.

Mechanism of Saccharomyces cerevisiae yeast cell death induced by heat shock. Effect of cycloheximide on thermotolerance.

The mechanism of yeast cell death induced by heat shock was found to be dependent on the intensity of heat exposure. Moderate (45°C) heat shock strongly increased the generation of reactive oxygen species (ROS) and cell death. Pretreatment with cycloheximide (at 30°C) suppressed cell death, but produced no effect on ROS production.