Pseudospin Quantum Hall Ferromagnetism Probed by Electron Spin Resonance.

We study the effect of the pseudospin ferromagnetism with the aid of an electrically detected electron spin resonance in a wide AlAs quantum well containing a high quality two-dimensional electron system. Here, pseudospin emerges as a two-component degree of freedom, that labels degenerate energy minima in momentum space populated by electrons. The built-in mechanical strain in the sample studied imposes a finite "Zeeman" splitting between the pseudospin "up" and "down" states.

[Epilepsy with PCDH19 mutation: polypharmacy as a consequence of the complexity and diversity of pathogenesis mechanisms].

Mutations in the human gene lead to epileptic encephalopathy of early childhood. It is characterized by the early onset of serial seizures, cognitive impairment and behavioral disorders (including autistic personality traits). In most cases, difficulties arise in selecting therapy due to pharmacoresistance.

Dispirooxindole-β-Lactams: Synthesis via Staudinger Ketene-Imine Cycloaddition and Biological Evaluation.

In this work, we present the first synthesis of dispirooxindole-β-lactams employing optimized methodology of Staudinger ketene-imine cycloaddition with N-aryl-2-oxo-pyrrolidine-3-carboxylic acids as the ketene source. Spiroconjugation of indoline-2-one with β-lactams ring is considered to be able to provide stabilization and wide scope of functionalization to resulting scaffolds. The dispipooxindoles obtained demonstrated medium cytotoxicity in the MTT test on A549, MCF7, HEK293, and VA13 cell lines, and one of the compounds demonstrated antibacterial activity against strain LPTD.

Spoof plasmons enable giant Raman scattering enhancement in Near-Infrared region.

Exceptionally strong enhancement of the Raman signal exceeding eight orders of magnitude for near-infrared (1064 nm) excitation is demonstrated for an array of dielectric submicron pillars covered by a relatively thick metal layer. The microstructure is designed to support 'spoof' plasmon-polariton excitations with resonant frequencies significantly below the fundamental surface plasmon resonance. Experiments reveal a relatively narrow range of spatial parameters for the optimal resonant scattering enhancement.

Characteristics of Depressive-Like Behavior of Prenatally Stressed Male Rats with Androgen Deficiency.

Characteristics of depressive-like behavior of male rats with androgen deficiency born by mothers subjected to prenatal stress during pregnancy were assessed by using Porsolt tests and open-field tests. The level of depression-like behavior in prenatally stressed males increased more intensively than in non-stressed gonadectomized males. Chronic administration of testosterone propionate (0.

[Differential diagnostics of the causes responsible for a cough in the pregnant women].

The objective of the present study was to elucidate the causes responsible for a cough in the pregnant women. It involved 92 patients including 23 ones presenting with bronchial asthma and 69 having no manifestations of asthma in their medical histories but suffering from dry cough that started after the beginning of pregnancy. All the patients were given counseling by the otorhinolaryngology and pulmonology specialists.

[Functional properties of dopaminergic neurons obtained from fibroblasts of a patient with PARK2 form of Parkinson's disease].

Objective: To carry out a functional analysis of dopamine transporter (DAT) in autosomal recessive Parkinson's disease caused by mutations in the PARK2 gene.

Material And Methods: Cultures of dopaminergic neurons were obtained from fibroblasts of a patient with PARK2 form of Parkinson's disease and a healthy donor with the use of the cell reprogramming technology. DAT expression in both cell cultures was assessed at the RNA and protein levels, and DAT activity was tested with the use of the fluorescent dopamine analogue ASP+.

Effects of SCH-23390 and sulpiride on active avoidance in ovariectomized rats treated with a low dose of 17β-estradiol.

We studied the effects of dopamine D1/D2 receptor antagonists on the dynamics of acquisition and extinction of active avoidance responses and open field behavior in ovariectomized female rats. Dopamine D1 receptor antagonist SCH-23390 (0.1 mg/kg intraperitoneally) and dopamine D2 receptor antagonist sulpiride (10.

[Influence of fluoxetine and paroxetine on anxiety-like behavior in young and adult prenatally stressed male rats].

The aim of the present work was an estimation of effects of chronic administration of selective serotonin reuptake inhibitors--fluoxetine (5.0 mg/kg, p.o.

[Co-administration of RJR-2403 with low dose of 17beta-estradiol on spatial learning in ovariectomized rats].

The aim of this work was to study the influence of stimulation or blockade Nalpha7-cholinoreceptors on dynamics of spatial learning in water Morris maze and on behavior in the "open field" test in adult ovariectomized (OVX) females given with a low dose of 17beta-estradiol. Agonist of Nalpha7-cholinoreceptors - RJR-2403 (1.0 mg/kg, i.

Effects of prenatal stress on the activity of the pituitary-ovarian system in female rats.

The comparative analysis of hormonal status was performed in mature female rats with experimental deficiency of estrogens, which mothers were exposed to stress during pregnancy. High levels of follicle-stimulating hormone and luteinizing hormone, and significantly lower amount of estradiol were observed in intact prenatally stressed females in comparison with intact non-stressed female rats. The increase in the levels of follicle-stimulating hormone and luteinizing hormone, and the decrease in estradiol concentration were more pronounced in blood serum of prenatally stressed ovariectomized rats as distinct from intact non-stressed and prenatally stressed female rats, and non-stressed ovariectomized female rats.

Analysis of the role of PrrA, PpsR, and FnrL in intracytoplasmic membrane differentiation of Rhodobacter sphaeroides 2.4.1 using transmission electron microscopy.

Oxygen dictates the catabolic "lifestyle" of Rhodobacter sphaeroides. When it is present, the bacteria are fully equipped for aerobic respiration. When it is absent, the cells outfit themselves to make use of energy-gathering options that do not require oxygen.

A bacterial phosphatase-like enzyme of the malaria parasite Plasmodium falciparum possesses tyrosine phosphatase activity and is implicated in the regulation of band 3 dynamics during parasite invasion.

Eukaryotic parasites of the genus Plasmodium cause malaria by invading and developing within host erythrocytes. Here, we demonstrate that PfShelph2, a gene product of Plasmodium falciparum that belongs to the Shewanella-like phosphatase (Shelph) subfamily, selectively hydrolyzes phosphotyrosine, as shown for other previously studied Shelph family members. In the extracellular merozoite stage, PfShelph2 localizes to vesicles that appear to be distinct from those of rhoptry, dense granule, or microneme organelles.

[Influence of fluoxetine and paroxetine on anxiety-like behavior in young and adult prenatally stressed male rats].

We present the results of a comparative analysis of the effects of the chronic administration of the selective serotonin reuptake inhibitors fluoxetine (5.0 mg/kg, p.o.

Effects of 8-OH-DPAT and NAN-190 on anxious-depressive-like behavior of female rats during the estrous cycle.

We studied the effect of chronic administration of 5-HT(1A)-receptor agonist 8-OH-DPAT (0.05 mg/kg subcutaneously) or antagonist NAN-190 (0.1 mg/kg intraperitoneally) for 14 days on anxious-depressive-like behavior of female rats during the key phases of the estrous cycle.

Pharmacological correction of testosterone deficiency during experimental myocardial ischemia.

Experiments on rats with myocardial ischemia modeled by occlusion of the left coronary artery aggravated by alimentary dislipoproteinemia showed that therapy with taurepar (50 mg/kg), a taurine derivative, decreased blood corticosterone concentration and increased the level of endogenous testosterone, which attests to normalization of the compensatory-adaptive and gonadotropic functions of the organism.

Blockade of 5-HT2A/2C-type receptors impairs learning in female rats in the course of estrous cycle.

We studied the effects of chronic administration (14 days) of agonist of 5-HT2B/2C serotonin receptors m-CPP (0.5 mg/kg subcutaneously) and agonist of 5-HT2A/2C serotonin receptors ketanserin (0.1 mg/kg intraperitoneally) on conditioned reactions in female rats in different phases of the estrous cycle.

Antiamnestic effect of alpha7-nicotinic receptor agonist RJR-2403 in middle-aged ovariectomized rats with Alzheimer type dementia.

The effects of chronic combined treatment with alpha7-nicotinic cholinergic receptor agonist RJR-2403 (1.0 mg/kg intraperitoneally) or alpha7-nicotinic cholinergic receptor antagonist mecamylamine (1.0 mg/kg intraperitoneally) and 17beta-estradiol (0.

Combined administration of NAN-190 and 17beta-estradiol abolishes the amnesic effect of scopolamine in middle-aged ovariectomized rats.

Chronic combined administration of 5-HT1A receptor antagonist NAN-190 and 17beta-estradiol improved conditioned passive avoidance performance in middle-aged ovariectomized rats with scopolamine-induced amnesia. Our results suggest that the ovarian hormonal, cholinergic, and serotoninergic systems play a role in age-related cognitive disturbances under conditions of hypoestrogenic syndrome.

Antiamnesic effect of combined treatment with galantamine and estradiol in middle-aged ovariectomized female rats.

The effect of chronic combined treatment with galantamine and 17beta-estradiol on passive avoidance retention was studied in middle-aged ovariectomized female rats (15 months) with scopolamine-induced amnesia. Combined treatment with galantamine and estradiol completely restored retrieval of memory traces in middle-aged ovariectomized female rats.

Effect of dehydroepiandrosterone on avoidance behavior of adult male rats.

We studied the effect of repeated intraperitoneal treatment with dehydroepiandrosterone in doses of 0.1 and 0.7 mg/kg on conditioned-response activity and behavior of adult male rats.

Modulatory effect of 8-OH-DPAT on behavior of ovariectomized female rats.

Behavior of ovariectomized rats was studied after chronic administration of serotonin 1A receptor agonist 8-OH-DPAT alone or in combination with 17beta-estradiol for 14 days. The effect of 8-OH-DPAT on learning was evaluated in the conditioned passive avoidance task. Behavioral activity in elevated plus-maze and open field was recorded.

The effect of L-tryptophan on conditioned reflex learning and behavior in rats with experimental pathology of the thyroid gland.

The effects of L-tryptophan on conditioned reflex learning and behavior were studied in male rats with deficient and excess thyroid hormones levels. The learning process was studied using a model consisting of a conditioned active avoidance response; animal behavior was assessed in an open field test. These studies showed that in conditions of thyroid hormone deficiency.

The effect of taurine derivative on lipid peroxidation and interhemispheric asymmetry of phospholipids from the brain synaptosomes in rats after immobilization stress.

Malondialdehyde (MDA) as an indicator of lipid peroxidation (LPO), content and composition of phospholipids (PL) were analyzed in synaptosomes of the rat brain hemispheres using immobilization stress without and with pretreatment with a new synthetic taurine derivative (STD). The stress was accompanied by a decrease MDA content, inversion of the initial asymmetry of total phospholipids (TPL) and modification PL composition in the brain hemispheres of rats. STD administration to the rats after stress antagonized the decrease of the MDA level, attenuates stress induced inversion TPL asymmetry and normalized PL composition in the brain hemispheres.

Behavioral effects of para-chlorophenylalanine in gonadectomized male rats.

Para-chlorophenylalanine restores impaired conditioning and retention of active avoidance reaction in castrated animals and improved their behavior in the open field test.