Publications by authors named "Fedosov A"
The Role of Changes in the Redox Status in the Pathogenesis of Chronic Lymphocytic Leukemia.
Dokl Biochem Biophys
December 2024
Chronic lymphocytic leukemia is a hemoblastosis of CD5 B lymphocytes with lymphocytosis, damage to the lymphatic organs, occurring in the older age group, the etiology and pathogenesis of which are not fully understood. Oxidative stress is an important factor in the regulation of stem cells and the activation of intracellular survival signaling pathways in chronic lymphocytic leukemia cells. The aim of the study was to analyze the current data on the role of redox status changes in the pathogenesis of chronic lymphocytic leukemia.
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- Venom systems have evolved multiple times across different plant and animal species and show variation based on factors like evolutionary history and diet.
- Marine cone snails (genus Conus) are a key model for studying these variations due to their diverse species and significant dietary shifts.
- Research on the venom genes of 42 cone snail species shows that changes from eating worms to fish lead to unique venom compositions that enhance potency, highlighting how prey choice influences venom characteristics.
Oncoplastic Breast Conservation for Central Tumors: Definition, Classification, and the Analysis of Single Institution Experience.
Plast Reconstr Surg Glob Open
May 2024
Background: Tumors in the central part of the breast are usually considered more aggressive and technically difficult, which limits breast conservation. The definition of central tumors from a surgical point of view, classification of the techniques for partial breast reconstruction, and conceptual algorithm of choice based on tumor and breast characteristics are proposed, along with the estimation of surgical and oncological safety.
Methods: This is a retrospective analysis of the single-institution experience, with a focus on the decision-making process for choosing the oncoplastic breast-conserving surgery technique.
Article Synopsis
- - DNA barcoding is crucial for identifying new species and understanding biodiversity; it's especially useful for classifying species using single-locus DNA sequences.
- - Various tools have been created for species delimitation, but many were not initially user-friendly, despite their common goal of identifying distinct species.
- - Recently, a standardized format called SPART has been introduced for sharing species partition data, and this chapter outlines protocols for using two specific bioinformatics tools, ASAP and LIMES, for species analysis.
Article Synopsis
- * Traditional species differentiation relies on morphological traits, but molecular methods are becoming essential for cryptic species.
- * The chapter presents protocols for the bioinformatics tool MolD, which helps identify diagnostic nucleotide combinations to improve DNA-based taxa differentiation.
Article Synopsis
- - The availability of user-friendly software for analyzing DNA barcodes is limited, often requiring complex procedures and manual formatting to perform basic functions like detecting gaps and calculating distance matrices.
- - The iTaxoTools project aims to create user-friendly solutions to enhance the workflow in alpha-taxonomy, focusing on improving the tool TaxI2 for analyzing DNA barcodes.
- - This chapter offers detailed protocols for using TaxI2, which can calculate genetic distances using various methods and format input data easily, while providing tools for comparing sequences against reference datasets and interpreting the results.
Article Synopsis
- - Venomous organisms have evolved toxins independently over 101 times, resulting in over 200,000 species that produce millions of toxins, making them significant for bioprospecting and genetic study.
- - RNA-seq is commonly used to analyze toxin repertoires, but current methods face challenges due to their reliance on similarity-based mapping, which doesn’t effectively utilize structural features of toxins.
- - DeTox is a new user-friendly tool that integrates structural and similarity-based approaches for toxin research, improving toxin identification in diverse organisms and easing the analysis process for those with less experience.
Article Synopsis
- - Neogastropoda is a diverse order of over 15,000 marine species that are significant for both ecological functions and the economies of coastal regions, but their evolutionary relationships are complex and poorly understood due to a dense "bush" in their evolutionary tree.
- - The study utilized various phylogenetic methods and a comprehensive dataset of 1,817 genetic loci from 112 taxa to analyze relationships within Neogastropoda, confirming the monophyly of several superfamilies while revealing that some currently recognized groups are paraphyletic.
- - Three major uncertainties were identified in the phylogenetic relationships, particularly concerning the placement of the Cancellariidae family, which could hint at deeper evolutionary interventions,
Long-term evaluation of combined prosthetic-surgical approach and soft tissue augmentation in the esthetic zone.
J Dent Res Dent Clin Dent Prospects
November 2023
Background: There is no standard protocol for immediate implant placement and subsequent loading in the smile zone. We aimed to evaluate the long-term outcomes of simultaneous implant placement, soft tissue grafting, and immediate prosthetic loading in the esthetic zone.
Methods: Thirty-five implants were placed in the maxillary aesthetic zone.
Article Synopsis
- In phylogenomic studies, taxon sampling often relies on known species, leading to the risk of missing out on undocumented diversity, particularly in groups like the Turridae, a family of venomous snails.* -
- Researchers developed a comprehensive sampling strategy that identified 201 species hypotheses using over 3,000 cox-1 barcode sequences, with nearly 50% of these potentially representing new or cryptic species.* -
- Their findings reveal the genus Gemmula is polyphyletic, containing up to 10 lineages, and emphasize the importance of blind and exploratory sampling to reduce biases in future phylogenomic research.*
Article Synopsis
- Venomous marine gastropods, particularly cone snails of the family Conidae, are highly diversified predators due to their complex venoms, which are valuable for studying neuropeptides and molecular evolution.
- Current research reveals that traditionally understood roles of venom production may involve not just the venom gland, but also other secretory glands (salivary and accessory salivary glands) that have not been fully explored.
- A detailed transcriptome analysis of Conus virgo highlights unique venom-related transcripts in the salivary and accessory glands, suggesting these tissues contribute to venom composition and warrant further functional studies to clarify their specific roles.
In order to search for innovative nootropic agents, new 1-benzyl-4- (4- (R)-5-sulfonylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl) pyrrolidine-2-ones was synthesized by reacting benzylamine with itaconic acid to 1-benzyl-5-oxopyrrolidine-3-carboxylic acid, which was then subjected to hydrazinolysis followed by the addition of substituted isothiacyanate followed by cyclization of intermediate thiosemicarbazides. The structure and purity of the obtained substances were confirmed by elemental analysis, H NMR spectroscopy, C NMR spectroscopy and LC/MS. Docking studies were performed for the substances synthesized using Autodock 4.
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- The Neogastropoda includes over 15,000 marine predator species, but their evolutionary relationships and classification are largely unclear.
- Researchers created a new molecular phylogeny using mitochondrial genomes and transcriptomic data from various neogastropod families, leading to the analysis of 113 taxa with multiple evolutionary models to construct phylogenetic trees.
- Despite revealing new relationships and insights, the study notes that key taxa are missing and suggests that alternative methods, like reduced-genome strategies, might be necessary for a complete understanding of neogastropod phylogeny.
Article Synopsis
- * Extensive tissue loss from tumor removal in this area needs immediate reconstruction to protect vital structures and prevent exposure to the environment.
- * A multidisciplinary approach was used in a recent operation, involving three specialized surgical teams working together, which allowed for simultaneous tumor removal and reconstruction using advanced techniques like free fibular flaps and dental implants.
The authors propose modifications of the lateral thoracic artery perforator/lateral intercostal artery perforator flap partial breast reconstruction that can help achieve improved aesthetic results, especially for centrally and medially located tumors. Lumpectomy is performed using the retromammary approach through lateral contour access without skin mobilization from parenchyma. This minimizes trauma and scarring of parenchyma and skin in the lateral part of the breast.
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- Venoms from marine cone snails are important for biomedical research due to their neuropeptides known as conotoxins, which have various applications.
- Some gastropods have developed similar venom-producing glands, particularly within the genus being studied, leading to the production of complex venoms termed vexitoxins.
- Research shows that vexitoxins share similarities with conotoxins in structure and function, suggesting a closer evolutionary relationship and offering insights into the evolution of venoms in these species.
Background: Conventionally, breast cancer (BC) prognosis and prediction of response to therapy are based on TNM staging, histological and molecular subtype, as well as genetic alterations. The role of various epigenetic factors has been elucidated in carcinogenesis. However, it is still unknown to what extent miRNAs affect the response to neoadjuvant chemotherapy (NACT).
View Article and Find Full Text PDFWe studied clinical status, content of products of LPO, and oxidative modification of proteins (OMP) in the lesion focus of the intestine in experimental colitis under conditions of rectal administration of ozone. Experimental colitis was simulated by two-stage administration of oxazolone; rectal insufflation of ozone in the ozone-oxygen mixture was performed daily. The disease activity index (DAI), the content of calprotectin in the feces, and LPO and OMP products in the intestinal homogenate were assessed.
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- A new software program called "mold" has been developed to identify diagnostic nucleotide combinations (DNCs) that provide formal diagnoses for specific taxa.
- The program also introduces a more reliable type of DNA diagnosis called "redundant DNC" (rDNC), which factors in unsampled genetic diversity, improving the reliability of taxonomic descriptions.
The authors believe that oncoplastic breast surgery has to achieve the best possible aesthetic results. In this article, they propose the concept of "invisible surgery." This is a combination of certain oncoplastic techniques that allows for restoration of the original appearance of the breast without obvious scars on the breast.
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- Marine gastropods known as cone snails exhibit a vast diversity of venomous compounds, which are of interest for biomedical research, yet their venom composition remains underexplored in many species.
- The study involved profiling the venom transcriptomes of two specific genera of cone snails for the first time, while leveraging data from two additional lineages to identify shared toxin clusters based on genetic regions.
- The researchers discovered numerous putative toxins and unexpected distributions of rare gene superfamilies, illustrating the importance of a phylogenetic approach in understanding venom evolution and complexity within the Conidae family.
Oncoplastic breast conserving surgery (BCS) becomes the standard of care in multidisciplinary breast cancer treatment. From our perspective, the aim of oncoplastic BCS is the best oncological, aesthetic and functional surgical treatment results. The study's objective is to present our approaches to the selection of surgical techniques and determine operative and oncological outcomes of oncoplastic surgery.
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- The study presents the complete mitochondrial genome sequence of a Caribbean gastropod species that typically inhabits sunken wood at deep ocean depths.
- This mitochondrial genome is 15,321 base pairs long, featuring a specific percentage of nucleotides: 29.2% Adenine (A), 41.8% Thymine (T), 12.0% Cytosine (C), and 17.0% Guanine (G).
- Phylogenetic analysis shows that this species belongs to the superfamily Turbinelloidea, which diverged early in the Neogastropod evolution and is closely related to several other superfamilies within the group.
Methyl 5-chloro-4-hy-droxy-2,2-dioxo-1-2λ,1-benzo-thia-zine-3-carboxyl-ate: structure and Hirshfeld surface analysis.
Acta Crystallogr E Crystallogr Commun
October 2020
The title compound, CHClNOS, which has potential analgesic activity, crystallizes in space group 2/. The benzo-thia-zine ring system adopts an inter-mediate form between sofa and twist-boat conformations. The coplanarity of the ester substituent to the bicyclic fragment is stabilized by an O-H⋯O intra-molecular hydrogen bond.
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- * The study characterizes a specific peptide from Drilliidae venom, named cdg14a, which is small and rich in disulfide bonds, and shows effects on mouse behavior, causing increased excitability in certain nerve cells.
- * Findings indicate that cdg14a could influence specific potassium channels, highlighting the potential of Drilliidae venoms as a source for developing new therapeutic agents targeting ion channels in the nervous system.