Glioblastoma management in a lower middle-income country: Nationwide study of compliance with standard care protocols and survival outcomes in Ukraine.

Background: The effective treatment of high-grade gliomas is a complex problem that requires ubiquitous implementation of sophisticated therapy protocols. The present study aimed to perform population-based analysis of glioblastoma management in lower-middle-income countries.

Methods: The National Cancer Registry of Ukraine was screened for the records of adult patients with primary glioblastomas diagnosed in 2015-2019.

MALIGNANT TUMORS IN PEDIATRIC POPULATION OF UKRAINE: TRENDS AND STRUCTURAL FEATURES.

Unlabelled: The creation of a central bank of personalized information of cancer patients, including children, allowed to obtain objective data and establish continuous cancer surveillance in the child population in Ukraine. The aim of the study was to analyze the dynamics of cancer incidence (1989-2019) and mortality (1999-2019) based on the 3 revision of International Classification of Childhood Cancer (ICCC-3).

Materials And Methods: A study cohort includes 31,537 patients aged 0-19 years at the time of diagnosis in 1989-2019, registered in Ukrainian population.

The signs of negative selection in IGHV framework regions are associated with worse overall survival of chronic lymphocytic leukemia patients.

The mutational status of the variable region of the immunoglobulin heavy chain (IGHV) genes remains the most significant prognostic factor in chronic lymphocytic leukemia (CLL) patients. However, the groups of mutated (M) and unmutated (UM) patients are also heterogeneous, and additional markers are used for a more accurate prognosis. The aim of our work was to determine the prognostic value of the signs of antigen selection determined by BASELINe statistics in M IGHV sequences of CLL patients.

INCIDENCE OF MALIGNANT NEOPLASMS AMONG RESIDENTS OF SMALL RADIONUCLIDE-CONTAMINATED CHORNOBYL DISTRICTS IN A POST-ACCIDENT PERIOD.

Objective: To assess the level of risks of development of malignant neoplasms among the residents of smallChornobyl districts («rayons») in connection with low-dose radiation exposure and its dynamic changes.

Materials And Methods: The study population included residents of Borodianka, Ivankiv and Poliske districts ofKyiv region («oblast») and Luhyny, Narodychi and Ovruch districts of Zhytomyr region, 175,100 inhabitants in2017. The study period was 1980-2017.

Burden of malignant melanoma in Ukraine in 2002-2013: incidence, mortality and survival.

Background: The malignant melanoma (MM) incidence rates were increasing and later stabilizing in many regions of the world, while in South-Eastern Europe incidence rates are uniformly increasing and mortality rates are higher.

Aim: To describe burden of MM in Ukraine in terms of incidence, mortality and survival by sex, age and stage for the period 2002-2013 and compare with European countries.

Materials And Methods: Database of the National Cancer Registry of Ukraine was used to extract MM incidence cases; number of MM deaths was obtained from the official mortality statistics.

Incidence and long-term effects of treatment of malignant germ cell neoplasms in Ukraine.

Aim: To describe incidence of malignant germ cell neoplasms (GCNs) in Ukraine and assess the medical care to patients with GCNs and its efficacy.

Materials And Methods: Records on 6495 males and 1038 females with malignant GCNs diagnosed in 2000-2013 extracted from the database of National Cancer Registry of Ukraine have been analyzed using methods of descriptive epidemiology and survival evaluation.

Results: In Ukraine, GCNs covered 79.

EPIDEMIOLOGY OF BREAST CANCER IN UKRAINE WITH CONSIDERATION OF THE FACTORS OF THE CHORNOBYL ACCIDENT.

Objective: Assessment of the possible impact of the Chornobyl accident on the incidence of breast cancer in the female population of Ukraine as a whole and in some affected groups.

Object Of The Study: The female population of Ukraine as a whole and in separate groups of victims - women par- ticipating in the clean-up works in 1986-1987, evacuaees from the exclusion zone and inhabitants of the territo- ries most contaminated with radionuclides.

Methods: Statistical, mathematical, cartographic.

RADIATION RISKS OF THYROID CANCER IN CHORNOBYL CLEAN-UP WORKERS USING THE ALTERNATIVE ESTIMATES OF DOSES OF EXTERNAL EXPOSURE.

Objective: The objective of this study was to estimate the thyroid cancer radiation risks - excess absolute risk(EAR), excess relative risk (ERR) and attributable fraction of risk (AR) in the cohort of 150,813 Ukrainian male clean-up workers during the 1986-2012 period (more than 25 years after the Chornobyl accident).

Materials And Methods: The cohort under study of 150,813 Ukrainian men who participated emergency and clean-up work in 1986-1990 was formed based on the data of the Ukrainian State Register of persons affected due toChornobyl accident (SRU). The identification of thyroid cancer cases (216) was carried out by linking the SRU data-base with the National Cancer Registry of Ukraine (NCRU) data.

Evaluation of data quality at the National Cancer Registry of Ukraine.

Background: Cancer notification has been mandatory in Ukraine since 1953, with the National Cancer Registry of Ukraine (NCRU) established in 1996. The aim of this study was to provide a comprehensive evaluation of the data quality at the NCRU.

Methods: Qualitative and semi-quantitative methods were used to assess the comparability, completeness, validity and timeliness of cancer incidence data from the NCRU for the period 2002-2012.

Image-guided resection of glioblastoma in eloquent brain areas facilitated by laser surface thermal therapy: clinical outcomes and long-term results.

The increased interest in the application of lasers in neuro-oncology prompted us to present our experience of using the laser technologies in the treatment of cerebral gliomas. The aim of the study was to evaluate the clinical efficacy of image-guided laser surface thermal therapy (LSTT) and its influence on survival of patients with glioblastoma (GBM).Data of 91 patients (49 males, 42 females, mean age 51.

Incidence of multiple myeloma among cleanup workers of the Chornobyl accident and their survival.

Unlabelled: The study presents the updated data on the multiple myeloma (MM) incidence in Ukrainian cleanup workers after the Chornobyl accident and their survival. The epidemiological analysis is based on the extended follow-up period to identify new MM cases for higher statistical power and to collect additional data on the disease course and outcome for the survival analysis. The objective of the study was to analyze the MM incidence and survival in Chornobyl cleanup workers in 1996-2013 in comparison with the national MM statistical data.

Thyroid Cancer and the Chornobyl Accident in Ukraine: Experience With the Implementation of a Follow-Up Programme.

Thyroid cancer incidence, its annual variation pattern and influence of gender and age at exposure were analyzed in population groups of Ukraine exposed to ionizing radiation by the Chornobyl accident. Significant radiation risks are demonstrated in the recovery operation workers and evacuees from Prypiat town and the exclusion zone. The radiation-induced excess of thyroid cancer is confirmed among people exposed as children and adolescents and subjects who had relatively high average thyroid radiation doses.

Experience of study of the incidence of malignant neoplasms population in small areas of Ukraine, which suffered contamination with radionuclides due to the Chornobyl accident.

Goal Of The Study: to evaluate the dynamics of implementation risks of malignant tumors in some small areas of Ukraine in the pre- and post-accident period.

Materials And Methods: The study population group - the population of the Malyn rayon, Zhytomyr region. The period of observation covered 1980-2014.

Quarter of century since the Chornobyl accident: сancer risks in affected groups of population.

Objective. The goal of this study was to define levels and dynamic trends of cancer incidence at whole and some separate sites in groups of Ukrainian population affected by the Chornobyl accident during a long period of observation. Materials and methods.

Age and gender patterns of thyroid cancer incidence in Ukraine depending on thyroid radiation doses from radioactive iodine exposure after the Chornobyl NPP accident.

Unlabelled: The objective of this study was to investigate the thyroid cancer incidence in a whole territory of Ukraine and to clear up its age and gender patterns depending on average regional (oblast) thyroid doses from radioactive iodine due to the Chornobyl accident. MATERIALS AND METHODS. On the basis of average accumulated thyroid doses from radioactive iodine the geographical regions of Ukraine with low and high average thyroid doses were identified for a comparative analysis performance.

Cancer incidence and nuclear facilities in Ukraine: a community-based study.

Unlabelled: The study goal was to investigate malignant tumors incidence in 5 Ukrainian cities with nuclear hazardous enterprises: extractive, processing enterprises of uranium ore (Zhovti Wody and Dniprodzerzhynsk of Dnipropetrovsk region) and nuclear power stations (Energodar of Zaporizhska region, Pivdennoukrainsk of Mykolayivska region, Netishyn of Khmelnytska region).

Materials And Methods: average annual population of the cities under study in 2003-2008 was 439 600 persons. Total and specific cancer incidence was investigated.

Thyroid cancer incidence in Ukraine: trends with reference to the Chernobyl accident.

For the first time, a comparative analysis of thyroid cancer incidence in Ukraine after the Chernobyl accident was done in a cohort that is almost as large as the general population. On the basis of thyroid doses from radioactive iodine in individuals aged 1-18 years at the time of accident, geographic regions of Ukraine with low and high average accumulated thyroid doses were established and designated "low-exposure" and "high-exposure" territories, respectively. A significant difference of thyroid cancer incidence rates as a function of time between the two territories was found.

[Primary multiple malignant neoplasms in patients with skin melanoma].

The problem of primary multiple malignant tumor (PMMT) of skin melanoma in Ukraine is analyzed. During the period from 2000 to 2006, 16760 cases of skin melanoma have been diagnosed, and in 873 patients from them PMMT has been registered. So, the part of the patients with multiple tumors among all patients with skin melanoma was 5.

[Cancer morbidity risks among workers of asbestos-cement productions].

The retrospective assessment of morbidity rates and cancer pathology risks in workers of asbestosis-cement enterprises of Ukraine has been made. It was established that annual cancer morbidity among workers makes 88,1 per 100 000 of workers (RR = 0.26, CI 95 % 0.

Twenty years after the Chernobyl accident: solid cancer incidence in various groups of the Ukrainian population.

Several major international studies such as those performed on the A-bomb survivors, have shown a clear linkage between the exposure to ionizing radiation and the occurrence of various cancer types including leukemia. While these studies are mostly characterized by high dose rates, studies on populations exposed after the Chernobyl accident are in most cases characterized by low dose rates which are typical for occupational radiation protection. Here, data on more than 60,000 Ukrainian workers who participated in recovery operation works in Chernobyl in 1986-1987, more than 50,000 evacuees from the city of Prypyat and the 30 km zone, and about 360,000 residents of most contaminated territories are presented, which cover a period of observation from 1980 to 2004.

[Informative value of the specialized registers in research of leukemia in Chernobyl accident liquidators in Ukraine].

The article considers the possibility of the use of current infrastructure of specialized population registers of Ukraine to study leukemia and other systemic blood diseases revealed in Chernobyl accident liquidators. Advantage and limitation of such registers in the use are discussed in the article. Ukrainian state register of people who suffered from Chernobyl accident and Ukrainian national cancer registers are the largest population registers in the country, which cover all the territory of Ukraine and contain information on each individual and may serve as source base for epidemiological studies.

[Corpus uteri cancer morbidity and a genetic-mathematical analysis of the proband's pedigrees].

Steady increase of the number of women that primary fell ill with uterus cancer has noted in Ukraine in 1980-1994. The clinic-genealogical analysis of the 262 families with uterus cancer patients of the Kiev region was made. Multifactorial type of heredity predominates.

[The state of and ways to improve diagnostic efficacy in the main forms of malignant neoplasms].

The state of diagnosis of malignant tumors in Ukraine concerning the indexes of opportunity, activity, accuracy was analysed. Complex of measures for an early detection of oncologic patients in all ranks of medical-sanitary aid to population was proposed.

[The terms and concepts for a standards base for an oncological service. I. The prevention and diagnosis of malignant neoplasms].

Establishing norms in an oncological service setting and of medico-technological standards for delivering oncological care to the population of Ukraine presupposes a uniform notion-terminological apparatus to be devised. The article presents current interpretation of the meaning of most widely used, leading traditional and newly coined terms and notions common in practical oncology, that subdivision of its dealing with prophylaxis and diagnosis of malignant tumors, for broad sections of medical workers who were not specially trained in the field.