Publications by authors named "Federico Zanzi"
Article Synopsis
- This study compares two surgical methods, Hartmann's procedure (HP) and resection with primary anastomosis (RPA), for treating acute left-sided colonic emergencies among 1215 patients from 204 centers globally.
- Results showed that while HP was the more common treatment (57.3%), RPA was favored for younger patients with fewer health issues and those needing surgery sooner.
- The study concluded that although HP is still widely used, RPA might be the better option, emphasizing the importance of patient characteristics and surgeon experience in determining treatment choice.
The presence of sarcopenia has been associated with the worst outcome of Crohn's disease (CD). At present, no studies have evaluated the impact of ustekinumab (UST) in terms of its effects on body composition. The aim of this prospective study was to evaluate whether UST treatment could modify the parameters of body composition as assessed by bioelectrical impedance assay (BIA) in patients with CD.
View Article and Find Full Text PDFArticle Synopsis
- The ChoCO-W study aimed to examine the effects of COVID-19 on the clinical presentation and outcomes of acute cholecystitis, particularly focusing on the rise of gangrenous cases during the pandemic.
- Over 2,800 patients from 42 countries were enrolled, with a notable 6.9% testing positive for COVID-19, revealing a significantly higher prevalence of preexisting conditions and more severe outcomes in this group compared to those without the virus.
- Patients with COVID-19 experienced higher postoperative complications (32.2% vs. 11.7%), longer hospital stays (13.21 days vs. 6.51 days), increased mortality rates (13.4% vs. 1.7
Article Synopsis
- Oncostatin M is a helpful blood marker that can show how well certain medicines work for people with inflammatory bowel diseases (IBD), especially when using anti-TNF drugs like infliximab.
- The study looked at two groups of IBD patients to see how well their treatment worked after 54 weeks, measuring oncostatin M and other markers in their blood and stool.
- Results showed that lower levels of oncostatin M before treatment were linked to better healing in patients taking anti-TNF drugs, but not in those on vedolizumab, indicating that oncostatin M is useful for predicting treatment success with anti-TNF medications.
Introduction: Methotrexate (MTX) is included in the therapeutic armamentarium of Crohn's disease (CD), although its positioning is currently uncertain in an era in which many effective biological drugs are available. No systematic reviews or meta-analysis have stratified the clinical outcomes of MTX according to the specific clinical scenarios of its use.
Methods: Medline, PubMed and Scopus were used to extract eligible studies, from database inception to May 2021.
Article Synopsis
- Adalimumab (ADA) is a monoclonal antibody used to treat inflammatory bowel diseases like Crohn's disease (CD), and vitamin D (VD) plays a role in drug metabolism and transport.
- This study aimed to assess how genetic variations in VD-related genes (single-nucleotide polymorphisms or SNPs) could predict clinical remission in CD patients treated with ADA over 3 and 12 months.
- Results showed that specific lifestyle and genetic factors influenced remission outcomes, highlighting the need for further research to validate these findings.
During the coronavirus disease 2019 (COVID-19) pandemic, immunomodulatory therapies and hospital admission were suspected to increase the risk of infection. Nevertheless, patients with inflammatory bowel diseases (IBD) treated with intravenous (i.v.
View Article and Find Full Text PDFUlcerative colitis (UC) is a chronic relapsing disease, which needs a continue monitoring, especially during biological therapies. An increasing number of patients is treated with anti-Tumor Necrosis factor (TNF) drugs, and current research is focalized to identify biomarkers able to monitor the disease and to predict therapeutic outcome. We enrolled consecutive UC patients treated with anti-TNF, naïve to biologic drugs.
View Article and Find Full Text PDFAnemia is a frequent complication of ulcerative colitis, and is frequently caused by iron deficiency. Oral iron supplementation displays high rates of gastrointestinal adverse effects. However, the formulation of sucrosomial iron (SI) has shown higher tolerability.
View Article and Find Full Text PDFThe COVID-19 pandemic has raised concerns about the negative impact of the fear of contagion on people's willingness to seek medical care and the subsequent effects on patients' prognosis. To date, not much is known about the outcomes of acute surgical diseases in this scenario. The aim of this multicenter observational study is to explore the effects of COVID-19 outbreak on the outcomes of patients who underwent surgery for peritonitis.
View Article and Find Full Text PDFIntroduction: Rates of elderly patients with inflammatory bowel diseases (IBDs) are increasing, and biomarkers are needed to optimise their therapies. Serum triiodothyronine-to-thyroxine (T3/T4) ratio has been correlated with geriatric patient frailty.
Aim: To assess the suitability of T3/T4 ratio as a response marker to biologics in elderly patients with IBD.
An unusual clinical presentation of colonic lipomatosis: A case report.
Int J Surg Case Rep
August 2020
Introduction: Colonic lipomatosis is defined as a poorly circumscribed, non-capsulated fat accumulation in the submucosal layer of the colonic wall. Clinical presentation varies from asymptomatic to acute surgical complications.
Presentation Of Case: We report the case of a 79-year old male who arrived at the Emergency Department complaining of worsening abdominal pain, fever and nausea.
Introduction: Biological therapies are widely used for the treatment of ulcerative colitis. However, only a low proportion of patients achieve clinical remission and even less mucosal healing. There is currently scarce knowledge about the early markers of therapeutic response, with particular regard to mucosal healing.
View Article and Find Full Text PDFArticle Synopsis
- A study in Italy evaluated the effectiveness and patient outcomes of abdominal hernia repairs using Phasix and Phasix ST biosynthetic meshes over a multi-center observational period from 2015 to 2019.
- The research focused on patients with moderate to severe hernias, examining complications and the quality of life over an 18-month follow-up, analyzing 75 patient cases.
- Results showed low complication rates (e.g., 8% recurrence, 4% superficial infections) and a significant improvement in quality of life, suggesting that Phasix meshes are effective in preventing hernia recurrence and enhancing patient well-being.
Fecal calprotectin has been widely studied in inflammatory bowel disease (IBD) under clinical and therapeutic settings. It showed a good correlation with clinical, endoscopic, and histologic findings. For these reasons, fecal calprotectin is currently one of the most useful tools in IBD care, both in diagnosis and in clinical management.
View Article and Find Full Text PDFBackground: Desmoid tumors (DTs) is a benign tumor with high tendency to infiltrative evolution and recurrence. Nowadays, in abdominal localization, the standard approach is surgery with R0 condition. The need to repair post-surgical wide wall defect requires conservative technique to decrease the incidence of incisional hernia and to obtain better quality of life (QoL).
View Article and Find Full Text PDFAim: To analyze GISTs behaviour observing their clinical evolution and outline the best approach to this neoplasia.
Material Of Study: In a period between December 1999 and October 2009 came to our observation, at the Institute of General Surgery, 37 patients with GIST. We conducted a retrospective study evaluating the anatomo-pathological aspects, the clinical situation and the tumour characteristics of the 37 patients with GIST.
Cutaneous melanoma is one of the most studied neoplastic lesions in biology and clinical oncology. It has been well documented that this type of neoplasm presents a high metastatic rate, and is able to involve nearly every tissue. Non-cutaneous melanoma represents an unusual pattern of melanoma, and the small intestine is an uncommon anatomic localization.
View Article and Find Full Text PDF