Publications by authors named "Federico Spataro"

Article Synopsis
  • Eosinophilic granulomatous polyangiitis (EGPA) is a rare autoimmune disease marked by inflammation and high eosinophil levels, traditionally treated with corticosteroids and immunosuppressants, which can have serious side effects.
  • A systematic review and meta-analysis of eight studies with 396 EGPA patients found that benralizumab, a biologic agent targeting the interleukin-5 receptor, significantly reduced oral corticosteroid use and led to remission in over half the patients.
  • The study concluded that benralizumab is an effective and well-tolerated treatment for EGPA, recommending further large-scale research to assess its long-term efficacy and safety.
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Article Synopsis
  • - Autoimmune skin disorders like Psoriasis, Vitiligo, and Alopecia Areata stem from genetic factors, environmental influences, and immune system issues, and there is a connection between autoimmune thyroid diseases and these skin conditions, particularly urticaria.
  • - The review explores links between autoimmune thyroiditis and various autoimmune skin disorders, highlighting shared genetic markers, immune mechanisms, and clinical relationships, such as IL-23 receptor gene variants increasing the risk for specific conditions.
  • - Common mechanisms like immune system breakdown and oxidative stress lead to inflammation, with similar antigens in skin cells and thyroid cells possibly explaining their co-occurrence, thus stressing the need for thorough diagnosis and treatment strategies, while suggesting more research on immunological pathways and biomarkers
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Background: Although randomized controlled trials (RCT) are the reference standard of evidence in allergen immunotherapy (AIT), nonrandomized studies (NRS) are needed to confirm their results in more representative populations, particularly for treatment duration and persistence. However, when discrepancies are observed between RCT and NRS, NRS reliability decreases because these discrepant results are generally attributed to the methodologic flaws of NRS.

Objective: We compared the benefit of sublingual AIT (SLIT) for allergic rhinoconjunctivitis in NRS versus RCT focusing on a single product/allergen to reduce heterogeneity.

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Lysosomal storage diseases (LSDs) are rare genetic metabolic disorders that cause the accumulation of glycosaminoglycans in lysosomes due to enzyme deficiency or reduced function. Enzyme replacement therapy (ERT) represents the gold standard treatment, but hypersensitivity reaction can occur resulting in treatment discontinuation. Thus, desensitization procedures for different culprit recombinant enzymes can be performed to restore ERT.

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Nonrandomized studies (NRS) on allergen immunotherapy (AIT) particularly lend themselves to evaluate outcomes that are insufficiently addressed in randomized controlled studies (RCTs). However, NRS are prone to several sources of bias, which limit their validity. We aimed at comparing AIT effects between RCTs and NRS and evaluate the reasons for discrepancies in study results.

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Background: Idursulfase and laronidase are drugs used to treat Hunter syndrome (mucopolysaccharidosis type 2) and Scheie syndrome (mucopolysaccharidosis type 1 S), respectively. These are rare lysosomal storage disorders, leading to accumulation of glycosaminoglycans within lysosomes. Failure of early recognition of the disease and/or delay in starting the appropriate treatment result in severe clinical impairment and death.

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Purpose Of Review: Severe asthma requires intensive pharmacological treatment to achieve disease control. Oral corticosteroids are effective, but their use is burdened with important side effects. Biologics targeting the specific inflammatory pathways underpinning the disease have been shown to be effective but not all patients respond equally well.

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