Publications by authors named "Federico Sierra"
There is scarce evidence for pulmonary artery denervation (PADN) as a potential treatment for chronic postcapillary pulmonary hypertension (PH). We aimed to perform a proof-of-concept of PADN in a translational model of chronic PH. Nineteen pigs with chronic postcapillary PH (secondary to pulmonary vein banding) were randomized to surgical-PADN (using bipolar radiofrequency clamps) or sham procedure.
View Article and Find Full Text PDFBackground: Pulmonary hypertension (PH) and right ventricular (RV) dysfunction are strong predictors of morbidity and mortality among patients with congenital heart disease. Early detection of RV involvement may be useful in the management of these patients. We aimed to assess progressive cardiac adaptation and quantify myocardial extracellular volume in an experimental porcine model of PH because of aorto-pulmonary shunt using cardiac magnetic resonance (CMR).
View Article and Find Full Text PDFArticle Synopsis
- Beta-3 adrenergic receptor (β3AR) agonists have shown promise in treating pulmonary hypertension (PH) by promoting vasodilation and improving heart function.
- In a study with pigs experiencing chronic PH, administration of β3AR agonists led to significant reductions in pulmonary vascular resistance (PVR) and enhancements in right ventricular (RV) performance over a two-week period.
- The research indicated that β3AR agonists not only effectively reduce PVR but also improve RV function, suggesting their potential as a new treatment option for chronic PH in humans.