Non-binary gender, vulnerable populations and mental health during the COVID-19 pandemic: Data from the COVID-19 MEntal health inTernational for the general population (COMET-G) study.

Background: The COVID-19 pandemic has brought significant mental health challenges, particularly for vulnerable populations, including non-binary gender individuals. The COMET international study aimed to investigate specific risk factors for clinical depression or distress during the pandemic, also in these special populations.

Methods: Chi-square tests were used for initial screening to select only those variables which would show an initial significance.

Somatic multicomorbidity and disability in patients with psychiatric disorders in comparison to the general population: a quasi-epidemiological investigation in 54,826 subjects from 40 countries (COMET-G study).

Background: The prevalence of medical illnesses is high among patients with psychiatric disorders. The current study aimed to investigate multi-comorbidity in patients with psychiatric disorders in comparison to the general population. Secondary aims were to investigate factors associated with metabolic syndrome and treatment appropriateness of mental disorders.

[Argentine consensus on the diagnosis and therapeutics of treatment resistant schizophrenia].

Approximately 30% of people with schizophrenia fail to respond to first-line antipsychotic treatment which impacts the burden of the disease. Treatment-resistant schizophrenia (TRS) denotes patients with failure to respond to at least two adequate trials of different antipsychotics. Clozapine is a unique drug approved for treating treatment-resistant schizophrenia, however 1/3 of patients fail to respond to clozapine.

Wernicke-Kleist-Leonhard phenotypes of endogenous psychoses: a review of their validity .

While the ICD-DSM paradigm has been a major advance in clinical psychiatry, its usefulness for biological psychiatry is debated. By defining consensus-based disorders rather than empirically driven phenotypes, consensus classifications were not an implementation of the biomedical paradigm. In the field of endogenous psychoses, the Wernicke-Kleist-Leonhard (WKL) pathway has optimized the descriptions of 35 major phenotypes using common medical heuristics on lifelong diachronic observations.

[Acute and chronic psychoses with cenestopathies and/or hypochondriacal symptoms].

Both cenestopathies (abnormal body sensations) and hypochondriac symptoms can occur in both acute and chronic psychotic disorders. The present article will brie?y describe some psychotic pictures that may accompanied with cenestopathies and/ or hypochondriacal symptoms. All descriptions will be illustrated with clinical examples to facilitate the understanding and delimitation of these diseases.

[Historical and conceptual evolution of non-schizophrenic psychotic disorders in DSM].

After firmly established the "kraepelinean dichotomy" (dementia praecox - manic-depressive insanity), classical psychiatry began to describe a group of psychotic disorders which did not fit in any of these main diagnoses. Many of these clinical pictures where incorporated to the DSM and underwent several changes throughout the successive editions of the American manual. This article aims to make a historical and conceptual overview of this group of non-schizophrenic psychotic disorders accompanying schizophrenia in the "Schizophrenia spectrum and other psychotic disorders" chapter of DSM-5.

[Pharmacological treatment of schizoaffective disorder, schizophreniform disorder and brief psychotic disorder].

This article reviews the available evidence for the pharmacological treatment of three of the psychotic disorders that are groupped together with schizophrenia in its chapter; one of them chronic -though episodic in its course- (schizoaffective disorder), two of them with acute symptomatology and restitutio ad integrum (schizophreniform disorder, brief psychotic disorder). The controversial position of these disorders in psychiatric nosology explains the scarce evidence for their pharmacological treatment. Anyhow, we shall try to stablish the main therapeutical approaches to these disorders.

[Some reflections on the changes observed in the Argentinean psychiatry in the last twenty years].

This article describes the consequences in the field of psychiatric knowledge of the political and economic neo-liberalization model than was installed from the beginnings of the 1980s: the rise of a psychiatry based on the use of diagnostic and therapeutic algorithms; the "mathematization" of symptoms through the use of scales; the superespecialization of the psychiatrist; the dissemination of psychiatric knowledge through the reading of papers; the acceptance of the statistical consensus; the preeminence of psychopharmacology; and the consolidation of the notion of "opinion leader".