Publications by authors named "Federico Pezzotta"
Article Synopsis
- A case of severe hemophilia A was reported in a 6-day-old newborn who exhibited severe symptoms, leading to a poor outcome.
- A literature review included 40 cases, identifying that most hemophilia A cases occurred within the first week of life, with a mix of familial and sporadic origins.
- Early detection is critical due to the rapid progression of symptoms; common signs include prolonged bleeding and neurological symptoms, which require prompt evaluation to rule out significant bleeding issues.
Article Synopsis
- The case report highlights the successful use of an Advanced Hybrid Closed Loop (AHCL) system for insulin treatment in a young patient with permanent neonatal diabetes mellitus (PNDM) due to a genetic condition.
- The patient transitioned from intravenous insulin to a Medtronic Minimed 780G insulin pump, and by age 2, automated insulin delivery significantly improved glycaemic control and met treatment goals.
- Over a one-month follow-up, there was a notable increase in Time in Range (TIR) and a reduction in hyperglycaemia, with no severe complications reported, emphasizing the importance of good glycaemic management for young patients' health and development.
Aim: To provide a comprehensive description of the clinical features, biochemical characteristics, and outcomes of infants up to 90 days old with COVID-19. Moreover, to assess the severity of the disease and propose an effective management pathway.
Methods: Retrospective single-center study spanning three years.
In this work, we developed and characterized a novel fluidic platform that enables long-term in vitro cell culture in a semi-automated fashion. The system is constituted by a control unit provided with a piezoelectric pump, miniaturized valves, and a microfluidic network for management and fine control of reagents' flow, connected to a disposable polymeric culture unit resembling the traditional multiwell-like design. As a proof of principle, Human Umbilical Vein Endothelial Cells (HUVEC) and Human Mesenchymal Stem Cells (hMSC) were seeded and cultured into the cell culture unit.
View Article and Find Full Text PDFPurpose: Phantoms mimicking human tissue heterogeneity and intensity are required to establish radiomic features robustness in Computed Tomography (CT) images. We developed inserts with two different techniques for the radiomic study of Non-Small Cell Lung Cancer (NSCLC) lesions.
Methods: We developed two insert prototypes: two 3D-printed made of glycol-modified polyethylene terephthalate (PET-G), and nine with sodium polyacrylate plus iodinated contrast medium.
Due to the complexity of liver surgery, the interest in 3D printing is constantly increasing among hepatobiliary surgeons. The aim of this study was to produce a patient-specific transparent life-sized liver model with tissue-like haptic properties by combining additive manufacturing and 3D moulding. A multistep pipeline was adopted to obtain accurate 3D printable models.
View Article and Find Full Text PDFIn this study, an efficient methodology for manufacturing a realistic three-dimensional (3D) cerebrovascular phantom resembling a brain arteriovenous malformation (AVM) for applications in stereotactic radiosurgery is presented. The AVM vascular structure was 3D reconstructed from brain computed tomography (CT) data acquired from a patient. For the phantom fabrication, stereolithography was used to produce the AVM model and combined with silicone casting to mimic the brain parenchyma surrounding the vascular structure.
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