Publications by authors named "Federico Occhiuzzi"
Article Synopsis
- Patients who have undergone total laryngectomy (TL) often experience lung issues related to smoking, making lung function assessment crucial through spirometry tests.
- Traditional spirometers are ineffective for these patients because they breathe through a tracheostomy instead of a mouthpiece.
- A new device designed with biocompatible polymer allows spirometry through the tracheostoma, has been tested on 5 TL patients, and proved to be comfortable, safe, and effective for diagnostics.
: The aim of our multicenter retrospective study was to evaluate the long-term complications associated with primary and secondary tracheoesophageal puncture (TEP) in patients who underwent total laryngectomy (TL) for laryngeal cancer and were subsequently rehabilitated to phonatory function with tracheoesophageal speech (TES). : To evaluate the long-term outcomes and complications of TEP, the following data were collected: mean time of prosthesis replacement, mean time of onset of complications, type of complications, and type of failure. : Complications occurred in 18 out of 46 patients (39.
View Article and Find Full Text PDFIn recent years, the number of open preservation surgeries for the treatment of laryngeal Cancer has increased. This surgery aims to maintain laryngeal function and ensure oncological radicality, thereby avoiding a total laryngectomy (TL) that could significantly impact the patient's quality of life. The purpose of this study was to assess the oncologic results of OPHL I and II and to identify prognostic factors that could impact patient survival and local failure rates.
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- Extracellular vesicles (EVs) facilitate cell-to-cell communication and are emerging as potential therapeutic agents, particularly in diseases like multiple sclerosis, where oligodendrocytes are damaged.
- The study explored using EVs to transport the glycoprotein transferrin (Tf), which is important for iron balance and helps oligodendrocyte differentiation, to the central nervous system via intranasal delivery.
- Results showed that Tf-loaded EVs could enter oligodendrocyte precursor cells (OPCs), promoting their maturation and speeding up the remyelination process in a rat model, while also demonstrating that EVs significantly reduce the amount of Tf needed for effective remyelination compared to using Tf alone.
We focus on the new prognostic and predictive factors CD44, PDL1, and ATG7 in our study of surgical samples of patients with laryngeal squamous cell carcinoma (LSCC) using tissue microarray (TMA). Thirty-nine previously untreated patients affected by laryngeal carcinoma who then underwent surgical treatment were considered in this retrospective study. All surgical specimens were sampled, embedded in paraffin blocks, and stained with hematoxylin and eosin.
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