Preserved Auditory Steady State Response and Envelope-Following Response in Severe Brainstem Dysfunction Highlight the Need for Cross-Checking.

Objectives: Commercially available auditory steady state response (ASSR) systems are widely used to obtain hearing thresholds in the pediatric population objectively. Children are often examined during natural or induced sleep so that the recorded ASSRs are of subcortical origin, the inferior colliculus being often designated as the main ASSR contributor in these conditions. This report presents data from a battery of auditory neurophysiological objective tests obtained in 3 cases of severe brainstem dysfunction in sleeping children.

Subcortical neural generators of the envelope-following response in sleeping children: A transfer function analysis.

Multiple auditory structures, from cochlea to cortex, phase-lock to the envelope of complex stimuli. The relative contributions of these structures to the human surface-recorded envelope-following response (EFR) are still uncertain. Identification of the active contributor(s) is complicated by the fact that even the simplest two-tone (f&f) stimulus, targeting its (f-f) envelope, evokes additional linear (f&f) and non-linear (2f-f) phase-locked components as well as a transient auditory brainstem response (ABR).

Implant survival rate in calvarial bone grafts: A retrospective clinical study with 10 year follow-up.

Background: In this study, we present medium- and long-term data on implant survival in a cohort of patients with severe maxillary atrophy rehabilitated using reconstructive implant site development with calvarial bone grafts.

Materials And Methods: We obtained clinical records from patients treated with implant rehabilitation supported by calvaria bone grafts in the Oral Surgery Department of IRCSS San Raffaele (Milan, Italy). Implant and prosthetic survival and success rates were retrospectively evaluated.

Automated epileptic seizure detection based on break of excitation/inhibition balance.

Physiological models are attractive for seizure detection, as their parameters are related to physiological meanings. We propose an algorithm to early detect epileptic seizures based on automatic estimation of average synaptic gains (excitatory Ae, slow and fast inhibitory B and G) by combining clinical data with a neural mass model. Three indices (Ae/B, Ae/G and Ae/(B + G)), all related to excitation/inhibition balance, were calculated and used as cues to detect seizures.

Generalization of the primary tone phase variation method: An exclusive way of isolating the frequency-following response components.

The primary tone phase variation (PTPV) technique combines selective sub-averaging with systematic variation of the phases of multitone stimuli. Each response component having a known phase relationship with the stimulus components phases can be isolated in the time domain. The method was generalized to the frequency-following response (FFR) evoked by a two-tone ( and ) stimulus comprising both linear and non-linear, as well as transient components.

Seizure evolution can be characterized as path through synaptic gain space of a neural mass model.

Physiologically based models could facilitate better understanding of mechanisms underlying epileptic seizures. In this paper, we attempt to reveal the dynamic evolution of intracranial EEG activity during epileptic seizures based on synaptic gain identification procedure of a neural mass model. The distribution of average excitatory, slow and fast inhibitory synaptic gain in the parameter space and their temporal evolution, i.

Dynamics underlying interictal to ictal transition in temporal lobe epilepsy: insights from a neural mass model.

We propose an approach that combines a neural mass model and clinical intracranial electroencephalographic (iEEG) recordings to explore the potential pathophysiological mechanisms (at the neuronal population level) of ictogenesis. Thirty iEEG recordings from 10 temporal lobe epilepsy (TLE) patients around seizure onset were investigated. Physiologically meaningful parameters [average excitatory (A ), slow (B), and fast (G) inhibitory synaptic gain] were identified during interictal to ictal transition.