Publications by authors named "Federico Grimoldi"
Article Synopsis
- The study evaluates Gas6, sAxl, and sMer as potential biomarkers for detecting pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) in patients with systemic sclerosis (SS) and scleroderma spectrum disorders (SSD).
- Nineteen patients were identified with pulmonary hypertension (14 specifically with PAH), while 39 had ILD, and specific plasma biomarkers showed significant differences based on these conditions.
- Plasma sMer levels were higher in PAH patients, while Gas6 and sAxl levels varied with ILD severity, indicating their potential utility for identifying these cardiopulmonary complications in SS and SSD.
Introduction/objective: In the present paper, we aimed to test the value of the red cell distribution width (RDW) coefficient of variation as a candidate biomarker for pulmonary arterial hypertension (PAH) in patients with connective tissue disorders (CTD), correlating it with the degree of cardiopulmonary impairment in these patients.
Methods: The study population included = 141 patients with CTD and = 59 patients affected by pulmonary hypertension of other etiologies, all referred to the Pulmonary Hypertension Clinic of the Cardiology Division of an Academic Hospital in Northern Italy for evaluation (including right catheterization). Clinical, instrumental, and laboratory data were collected and related to RDW and other full blood count indexes.