Publications by authors named "Federico Dosi"
Article Synopsis
- (1,5)-1-Hydroxy-3,6-dioxa-bicyclo[3.2.1]octan-2-one was synthesized from cellulose and used to create seven new nucleoside analogues with specific structural modifications.
- Their synthesis involved the Mitsunobu reaction, and the configurations were confirmed using 2D-NOESY and DFT methods.
- An in silico screening identified one compound as a promising SARS-CoV-2 inhibitor, demonstrating stable interaction with RNA-dependent RNA polymerase (RdRp) and potentially better binding than existing treatments like GS-441524.
Cellulose represents a key component of a renewable biomass source, from which chiral compounds with a high added value in the application for the synthesis of potentially bioactive molecules can be obtained. The anhydrosugar (1R,5S)-1-hydroxy-3,6-dioxa-bicyclo[3.2.
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