Can FDG-PET assess the response to chemotherapy and predict tissue necrosis in osteosarcoma and Ewing sarcoma?

Osteosarcoma (OS) and Ewing sarcoma (ES) represent the pediatric population's most common malignant bone tumors. 18-Fluorodeoxyglucose positron emission tomography has been shown to be effective in both the diagnostic and staging phases of cancer treatment. In recent years, some studies have also explored the possibility that FDG-PET could have a prognostic role.

Bone turnover profile and muscular status in major orthopaedic surgery: a case series.

BACKGROUND Sarcopenia refers to a chronic loss of skeletal muscle mass, often associated with hypovitaminosis D and advanced age, which involves a greater risk of falls and fractures. The association of sarcopenia and osteoporosis defines osteo-sarcopenia. In this work, the authors analyzed the osteometabolic profile and the loco-regional muscular state of patients undergoing major orthopedic surgery, in order to define the incidence of district osteosarcopenic states, linked to a condition of disuse.

Use of Teriparatide in preventing delayed bone healing and nonunion: a multicentric study on a series of 20 patients.

Background: Delayed bone healing and nonunions represent a great challenge for the orthopedic surgeon. In addition to traditional surgical approaches, increasing attention is being given to the use of systemic anabolic therapy with Teriparatide, whose efficacy in preventing osteoporotic fractures is widely validated and whose application as a promoter of bone healing has been described but it is still debated. The aim of the study was to evaluate bone healing in a series of patients with delayed unions or nonunions treated with Teriparatide in conjunction with eventual appropriate surgical procedure.

Reconstruction of the Extensor Apparatus Using a Hybrid Augment with Polyethylene Mesh and Fascia Lata Allograft: Report of a Case with Patellar Gigant Cell Tumor of the Bone.

Introduction: The extensor apparatus of the knee can be thought of a chain that transmits the muscular strength developed by the quadriceps muscles to the proximal tibia. This complex is essential to allow the extension of the tibia over the femur, being essential to provide knee mobility and stability. In case of lesions which irreparably damage the patella, such as a locally aggressive bone tumor, it is necessary to restore both the apparatus' anatomical continuity and its strength.

Systematic Investigation on the Structure-Property Relationship in Isotactic Polypropylene Films Processed via Cast Film Extrusion.

The effect of cast film extrusion processing conditions, such as the chill-roll temperature, temperature of the melt, and line speed, on the structure of different isotactic polypropylene homo- and random copolymers has been investigated by means of Small- and Wide-Angle X-ray Scattering (SAXS and WAXS) and correlated to stiffness and haze. Stiffness and transparency have been found to be strongly dependent on the temperature of the chill-roll. Interestingly, line speed has been found to affect the total crystallinity when the chill-roll temperature is increased, while an overall minor effect of the melt temperature was found for all cast films.

Versatile Multi-Functional Block Copolymers Made by Atom Transfer Radical Polymerization and Post-Synthetic Modification: Switching from Volatile Organic Compound Sensors to Polymeric Surfactants for Water Rheology Control via Hydrolysis.

Novel, multipurpose terpolymers based on styrene (PS), tert-butyl methacrylate (tBMA) and glycidyl methacrylate (GMA), have been synthesized via Atom Transfer Radical Polymerization (ATRP). Post-synthetic modification with 1-pyrenemethylamine (AMP) allows non-covalent functionalization of carbon nanotubes, eventually yielding a conductive nanocomposite materials capable of interacting with different Volatile Organic Compounds (VOCs) by electrical resistance variation upon exposure. Moreover, facile hydrolysis of the tBMA group yields polyelectrolytic macrosurfactants with remarkable thickening properties for promising applications in water solution, such as Enhanced Oil Recovery (EOR).