Complete genome sequence of multidrug-resistant and NDM-producing clinical isolates.

Recently, global dissemination of NDM-producing in hospital settings and natural environments has been described. This study described the whole-genome sequencing of multidrug-resistant phenotype and NDM-producing clinical isolates.

Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases.

Objective: To analyze the current knowledge of pathogen-insect interactions amenable for the design of molecular-based control strategies of vector-borne diseases.

Materials And Methods: We examined malaria, dengue, and Chagas disease pathogens and insect molecules that participate in interactions during their vectors infection.

Results: Pathogen molecules that participate in the insect intestine invasion and induced vector immune molecules are presented, and their inclusion in transmission blocking vaccines (TBV) and in genetically modify insect (GMI) vectors or symbiotic bacteria are discussed.

Comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of Imd canonical components among hemimetabolous arthropods.

Background: Insects operate complex humoral and cellular immune strategies to fend against invading microorganisms. The majority of these have been characterized in Drosophila and other dipterans. Information on hemipterans, including Triatominae vectors of Chagas disease remains incomplete and fractionated.