Outcomes in pregnancies with a confined placental mosaicism and implications for prenatal screening using cell-free DNA.

Purpose: To assess the association between confined placental mosaicism (CPM) and adverse pregnancy outcome.

Methods: A retrospective cohort study was carried out evaluating the outcome of pregnancies with and without CPM involving a rare autosomal trisomy (RAT) or tetraploidy. Birthweight, gestational age at delivery, fetal growth restriction (FGR), Apgar score, neonatal intensive care admission, preterm delivery, and hypertensive disorders of pregnancy were considered.