Publications by authors named "Federica Scaroni"
Article Synopsis
- - Microglia and macrophages produce extracellular vesicles (EVs) that can affect the development of myelin lesions, with microglial EVs supporting oligodendrocyte precursor cell (OPC) differentiation, while the effect of macrophage EVs is less clear.
- - Research showed that EVs from macrophages, especially those in an inflammatory state, do not aid OPC differentiation and actually inhibit it, but their lipid content can still promote OPC maturation similar to microglial EVs.
- - Key promyelinating endocannabinoids (like anandamide) were found in EVs from both cell types, indicating a critical role for these endocannabinoids in OPC maturation and suggesting potential targets for enhancing myelin repair
Cognitive deficits strongly affect the quality of life of patients with multiple sclerosis (MS). However, no cognitive MS biomarkers are currently available. Extracellular vesicles (EVs) contain markers of parental cells and are able to pass from the brain into blood, representing a source of disease biomarkers.
View Article and Find Full Text PDFAstrocytes-derived extracellular vesicles (EVs) are key players in glia-neuron communication. However, whether EVs interact with neurons at preferential sites and how EVs reach these sites on neurons remains elusive. Using optical manipulation to study single EV-neuron dynamics, we here show that large EVs scan the neuron surface and use neuronal processes as highways to move extracellularly.
View Article and Find Full Text PDFIt is widely recognized that monocytes-macrophages adopt a wide variety of phenotypes, influencing the inflammatory activity and demyelination in Multiple Sclerosis (MS). However, how the phenotype of human monocytes evolves in the course of MS is largely unknown. The aim of our preliminary study was to analyse in monocytes of relapsing-remitting and progressive forms of MS patients the expression of a set of miRNAs which impact monocyte-macrophage immune function and their communication with brain cells.
View Article and Find Full Text PDFArticle Synopsis
- - Microglia, the brain's immune cells, can either promote or inhibit the repair of myelin, a protective layer around nerve fibers, in conditions like multiple sclerosis, depending on their activation state.
- - The study found that extracellular vesicles (EVs) from pro-inflammatory microglia hindered myelin repair, while those from microglia working with mesenchymal stem cells promoted the recruitment of oligodendrocyte precursor cells (OPCs) for remyelination.
- - The research also revealed that astrocytes (another type of brain cell) can be negatively affected by pro-inflammatory EVs, which disrupt OPC maturation, suggesting that EVs have complex roles in signaling and may hold potential for new treatments for