Publications by Federica Ricciutelli

Publications by authors named "Federica Ricciutelli"

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Treatment with proton pump inhibitors is associated with secondary bacterial infections and sepsis in patients with COVID-19: a retrospective analysis of their joint impact on in-hospital prognosis.

Vanessa Bianconi Massimo R Mannarino Filippo Figorilli Federica Ricciutelli Stefania De Carlo

Ann Med

December 2024

Article Synopsis

Secondary bacterial infections (SBIs) are linked to worse hospital outcomes for COVID-19 patients, with prior treatment using proton pump inhibitors (PPIs) increasing the risk of these infections.
In a study of 1,087 hospitalized COVID-19 patients, 41% were on PPIs prior to admission, leading to higher rates of SBIs (18%) and secondary bacterial sepsis (SBS) (20%).
PPI treatment was associated with a significantly greater risk of developing SBIs and SBS, which in turn increased the likelihood of ICU admissions or in-hospital deaths, highlighting the need for cautious PPI use in these patients.

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Lipoprotein(a) Does Not Predict Thrombotic Events and In-Hospital Outcomes in Patients with COVID-19.

Vanessa Bianconi Massimo R Mannarino Federica Ramondino Jessica Fusaro Francesco Giglioni Federica Ricciutelli

J Clin Med

May 2023

The prothrombotic and proinflammatory properties of lipoprotein(a) (Lp(a)) have been hypothesized to play a role in the pathogenesis of severe COVID-19; however, the prognostic impact of Lp(a) on the clinical course of COVID-19 remains controversial. This study aimed to investigate whether Lp(a) may be associated with biomarkers of thrombo-inflammation and the occurrence of thrombotic events or adverse clinical outcomes in patients hospitalized for COVID-19. We consecutively enrolled a cohort of patients hospitalized for COVID-19 and collected blood samples for Lp(a) assessment at hospital admission.

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