Publications by authors named "Federica Renzulli"
Background: In women with recurrent disease who were conservatively treated for atypical endometrial hyperplasia (AEH) and early endometrial carcinoma (EEC), the reasons why conservative treatment was chosen persist and outcomes of performing a conservative re-treatment are unclear, as pooled estimates on oncologic outcomes of such a re-treatment are lacking.
Objectives: To provide pooled estimates of oncologic outcomes of conservative re-treatment in women with recurrent AEH or EC.
Search Strategy: A systematic review and meta-analysis was performed by searching six electronic databases from their inception to March 2022.
Objective: In endometrial carcinoma patients, sentinel lymph node bilateral mapping fails in 20-25% of cases, with several factors affecting the likelihood of detection. However, pooled data about predictive factors of failure are lacking. The aim of this systematic review and meta-analysis was to assess the predictive factors of sentinel lymph node failed mapping in endometrial cancer patients undergoing sentinel lymph node biopsy.
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- Endometrial cancer arising in adenomyosis (EC-AIA) is a rare and challenging uterine disease with malignant transformations often occurring in menopausal women.
- The study reviewed existing literature from 2002 to 2022, analyzing 37 cases found in case reports and series, highlighting that EC-AIA shares symptoms with regular endometrial cancer but is more difficult to diagnose preoperatively.
- Key findings indicate EC-AIA has a higher prevalence of non-endometrioid histotypes and advanced cancer stages, leading to a worse prognosis, emphasizing the need for more extensive future research to better understand this condition.
Robotic surgery has been approved as an alternative to laparoscopy to improve surgical outcomes. There is neither a consensus nor a systematic assessment of the literature about the superiority of the robotic approach over the laparoscopic one for sentinel lymph node (SLN) biopsy in endometrial carcinoma (EC) women. Therefore, a systematic review and meta-analysis was performed to compare the laparoscopic and robotic approaches for SLN biopsy in EC patients.
View Article and Find Full Text PDFPrevalence and Risk Factors of Central Sensitization in Women with Endometriosis.
J Minim Invasive Gynecol
January 2023
Study Objective: To assess prevalence of central sensitization (CS) and its association with demographic and clinical factors in patients with endometriosis.
Design: Single-center, observational, cross-sectional study.
Setting: Tertiary center.
Objective: To assess uterine artery arteriosclerosis prevalence in women undergoing total hysterectomy for benign diseases, and any associations between clinical, laboratory, and ultrasound factors and uterine artery arteriosclerosis occurrence.
Methods: A single center, observational, prospective, cohort study was performed enrolling all symptomatic patients scheduled for total hysterectomy from May to December 2021. Our outcomes were: uterine artery arteriosclerosis prevalence and the difference in clinical, laboratory, and ultrasonographic factors between patients with and without uterine artery arteriosclerosis.
Background: Despite a debate spanning two decades, no consensus has been achieved about the safest laparoscopic entry technique.
Objectives: To update the evidence about the safety of the main different laparoscopic entry techniques.
Search Strategy: Six electronic databases were searched from inception to February 2021.
Although Tao brush has become one of the most studied and used endometrial cytological samplers, concerns remain about the adequacy of the cytological sample compared with definitive histology. We aimed to assess accuracy of cytological examination from Tao brush sampling in diagnosing endometrial premalignancy and malignancy through a systematic review and meta-analysis. Seven electronic databases were searched from January 2000 to July 2021 for all studies which allowed assessment of accuracy of Tao brush in diagnosing endometrial premalignancy and malignancy.
View Article and Find Full Text PDFBackground: 2021 ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma (EC) encourage molecular classification and propose a new prognostic risk stratification based on both pathologic and molecular features. Although deep myometrial invasion (DMI) has been considered as a crucial risk factor in EC, it is unclear if its prognostic value is independent from The Cancer Genome ATLAS (TCGA) groups.
Aim: To assess if the prognostic value of DMI is independent from the TCGA groups in EC patients.