Envisioning the sustainable and climate resilient hospital of the future.

Objectives: This study aims to create a vision of the future hospital to help healthcare leaders understand how changes in society and the healthcare system, compounded by climate change, could affect future hospital estate.

Study Design: The study is part of a larger project based on participatory backcasting aimed at providing integrated strategies for transitioning to a zero-carbon future and adapting to existing climate change through improved asset management.

Methods: The data presented in this paper were collected during a full-day workshop to construct the vision of the future hospital in 2050.

Implementation of a strategy involving a multidisciplinary mobile unit team to prevent hospital admission in nursing home residents: protocol of a quasi-experimental study (MMU-1 study).

Introduction: Nursing home residents represent a particularly vulnerable population experiencing high risk of unplanned hospital admissions, but few interventions have proved effective in reducing this risk. The aim of this research will be to verify the effects of a hospital-based multidisciplinary mobile unit (MMU) team intervention delivering urgent care to nursing home residents directly at their bedside.

Methods And Analysis: Four nursing homes based in the Parma province, in Northern Italy, will be involved in this prospective, pragmatic, multicentre, 18-month quasiexperimental study (sequential design with two cohorts).

MicroRNA-138 is a Prognostic Biomarker for Triple-Negative Breast Cancer and Promotes Tumorigenesis via TUSC2 repression.

Breast cancer manifests as a spectrum of subtypes with distinct molecular signatures, and different responses to treatment. Of these subtypes, triple-negative breast cancer (TNBC) has the worst prognoses and limited therapeutic options. Here we report aberrant expression of microRNA-138 (miR-138) in TNBC.

C/EBPβ mediates RNA polymerase III-driven transcription of oncomiR-138 in malignant gliomas.

MicroRNA-138 (miR-138) is a pro-survival oncomiR for glioma stem cells. In malignant gliomas, dysregulated expression of microRNAs, such as miR-138, promotes Tumour initiation and progression. Here, we identify the ancillary role of the CCAAT/enhancer binding protein β (C/EBPβ) as a transcriptional activator of miR-138.

HBN guidance sets out key principles.

With an ageing population in many countries, health and social care providers are under growing pressure to improve the quality and safety of care environments for older people, and ensure they are fit-for-purpose for caring for those with age-related conditions, including dementia. Health Building Note 08-02: Dementia-friendly health and social care environments, recently published, is the first HBN to offer specific guidance on the subject. Here Loughborough University research associates, Efthimia Pantzartzis and Federica Pascale, and Andrew Price, who is Professor of Project Management at the University, explain the background to the new HBN, and offer insights into its structure and content.