Nociception level index variations in ICU: curarized vs non-curarized patients - a pilot study.

Purpose: Pain is a major physiological stressor that can worsen critical medical conditions in many ways. Currently, there is no reliable monitoring tool which is available for pain monitoring in the deeply sedated ± curarized critically ill patients. This study aims to assess the effectiveness of the multiparameter nociception index (NOL®) in the critical care setting.

Mesoscopic non-equilibrium measures can reveal intrinsic features of the active driving.

Biological assemblies such as chromosomes, membranes, and the cytoskeleton are driven out of equilibrium at the nanoscale by enzymatic activity and molecular motors. Similar non-equilibrium dynamics can be realized in synthetic systems, such as chemically fueled colloidal particles. Characterizing the stochastic non-equilibrium dynamics of such active soft assemblies still remains a challenge.

Scaling behavior of nonequilibrium measures in internally driven elastic assemblies.

Detecting and quantifying nonequilibrium activity is essential for studying internally driven assemblies, including synthetic active matter and complex living systems such as cells or tissue. We discuss a noninvasive approach of measuring nonequilibrium behavior based on the breaking of detailed balance. We focus on "cycling frequencies"-the average frequency with which the trajectories of pairs of degrees of freedom revolve in phase space-and explain their connection with other nonequilibrium measures, including the area enclosing rate and the entropy production rate.

Nonequilibrium Scaling Behavior in Driven Soft Biological Assemblies.

Measuring and quantifying nonequilibrium dynamics in active biological systems is a major challenge because of their intrinsic stochastic nature and the limited number of variables accessible in any real experiment. We investigate what nonequilibrium information can be extracted from noninvasive measurements using a stochastic model of soft elastic networks with a heterogeneous distribution of activities, representing enzymatic force generation. In particular, we use this model to study how the nonequilibrium activity, detected by tracking two probes in the network, scales as a function of the distance between the probes.

Effects of shear flow on phase nucleation and crystallization.

Classical nucleation theory offers a good framework for understanding the common features of new phase formation processes in metastable homogeneous media at rest. However, nucleation processes in liquids are ubiquitously affected by hydrodynamic flow, and there is no satisfactory understanding of whether shear promotes or slows down the nucleation process. We developed a classical nucleation theory for sheared systems starting from the molecular level of the Becker-Doering master kinetic equation and we analytically derived a closed-form expression for the nucleation rate.

Oncologic outcome of hypopharyngeal carcinoma treated with different modalities at 2 different university hospitals.

Background: The hypopharynx is the site with the worst prognosis among head and neck squamous cell carcinomas (SCCs). The purpose of this study was to evaluate the oncologic outcomes of hypopharyngeal SCCs to identify the major clinical predictive factors and to compare the different primary therapeutic modalities.

Methods: The medical records of 123 consecutive patients diagnosed with primary resectable hypopharyngeal SCC were reviewed.

Oral HPV infection and persistence in patients with head and neck cancer.

Objective: To investigate the presence and persistence of human papillomavirus (HPV) infection in the oral mucosa of patients with head and neck squamous cell carcinoma (HNSCC), and its correlation with prognosis.

Study Design: HPV infection was characterized in tumors and pre and posttreatment oral scrapings in 51 patients with HNSCC and matched controls using the SPF10 LiPA Extra assay. p16INK4A immunostain and in situ hybridization for high-risk HPV genotypes recognized transcriptionally active infection in tumor samples.

Electrochemotherapy for the treatment of recurrent head and neck cancers: preliminary results.

Aims And Background: Electrochemotherapy is a tumor ablation modality providing delivery into the cell interior of impermeant or poorly permeant chemotherapeutic drugs such as cisplatin and bleomycin. A locally applied electrical field enhances the membrane permeability allowing intracellular accumulation of the chemotherapeutic agent. The aim of the study was to evaluate the effectiveness of ECT for the treatment of a group of patients affected by recurrent of extended primary head and neck cancer and not suitable for standard therapeutic options.