Publications by authors named "Federica Mossa"
Background: Senescence classification is an acknowledged challenge within the field, as markers are cell-type and context dependent. Currently, multiple morphological and immunofluorescence markers are required. However, emerging scRNA-seq datasets have enabled an increased understanding of senescent cell heterogeneity.
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- Senescence acts as a protective mechanism against tumor growth, but cancer cells often lose important components like p16INK4A that promote this state.
- Some tumors display both signs of rapid growth and markers typical of senescence, creating a complex situation that poses challenges for accurate classification.
- The text examines the outlook for identifying these Sen-Mark+ cells and discusses potential therapeutic approaches that could utilize the senescence process in cancer treatment.
Unlabelled: Aberrant metabolic functions play a crucial role in prostate cancer progression and lethality. Currently, limited knowledge is available on subtype-specific metabolic features and their implications for treatment. We therefore investigated the metabolic determinants of the two major subtypes of castration-resistant prostate cancer [androgen receptor-expressing prostate cancer (ARPC) and aggressive variant prostate cancer (AVPC)].
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