Publications by authors named "Federica Maria Angela Rizzi"
Biobased composites with peculiar properties offer an attractive route for producing environmentally friendly materials. The reinforcement for poly(butylene adipate--terephthalate) (PBAT), based on zein-titanium dioxide (TiO) complex (ZTC) microparticles, is presented and used to produce composite filaments, successfully 3-dimensionally (3D) printed by fused deposition modeling (FDM). The outcome of ZTC addition, ranging from 5 to 40 wt %, on the thermo-mechanical properties of composite materials was analyzed.
View Article and Find Full Text PDFArticle Synopsis
- - Genomic studies on acute lymphoblastic leukemia (ALL) have uncovered recurring genetic changes related to DNA methylation and histone modifications, pointing to potential new treatment options.
- - The study identified G9a/EHMT2 as a promising target for T-ALL therapy by combining epigenetic screens with chemical analysis and confirmed its role through various targeted experiments.
- - Findings suggest that inhibiting G9a leads to increased lysosomal activity and autophagy, affecting key metabolic pathways in T-ALL cells, thereby proposing G9a as a viable strategy to disrupt the metabolism of these cancer cells.
Considering that Aurora kinase inhibitors are currently under clinical investigation in hematologic cancers, the identification of molecular events that limit the response to such agents is essential for enhancing clinical outcomes. Here, we discover a NF-κB-inducing kinase (NIK)-c-Abl-STAT3 signaling-centered feedback loop that restrains the efficacy of Aurora inhibitors in multiple myeloma. Mechanistically, we demonstrate that Aurora inhibition promotes NIK protein stabilization downregulation of its negative regulator TRAF2.
View Article and Find Full Text PDF