Publications by authors named "Federica Feo"

Artificial Intelligence (AI) encompasses the development of computer systems capable of tasks typically requiring human intelligence, such as visual perception, speech recognition, decision-making, and language translation. Over time, numerous applications have emerged, with AI's integration into medicine marking a significant leap forward in healthcare delivery, diagnosis, and treatment. Among medical specialties, dermatology stands at the forefront of AI advancements, leveraging machine learning and deep learning to enhance dermatologists' abilities and improve patient care.

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Article Synopsis
  • The intersection of artificial intelligence (AI) and medicine has led to significant advancements in healthcare, particularly in the field of dermatology.
  • A review of 20 research papers highlighted various applications of ChatGPT, an AI tool, in dermatology, which includes enhancements in clinical practice and patient support.
  • ChatGPT is positioned as a key player in modern healthcare, helping to bridge gaps in communication and knowledge sharing between patients and clinicians.
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  • Current psoriasis therapies face challenges like patient compliance, safety concerns, effectiveness issues, and side effects, leading to ongoing clinical trials for new treatments.
  • This review aims to summarize existing research and explore trends in psoriasis management, utilizing resources like PubMed and clinicaltrials.gov.
  • Despite available treatments, there is a need for more effective options for moderate to severe psoriasis, emphasizing the importance of developing innovative therapies to tailor patient care and improve outcomes.
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  • GM3 synthase deficiency (GM3SD) is linked to mutations in the ST3GAL5 gene, leading to severe symptoms like irritability, feeding issues, seizures, and hearing loss in infants.
  • Researchers created and studied a human induced pluripotent stem cell (hiPSC) line from a 13-year-old girl with GM3SD who had two new genetic variants in the ST3GAL5 gene.
  • The hiPSC line possesses a normal chromosome structure, expresses markers indicating pluripotency, and can develop into the three primary cell types in the body.
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Introduction: Nowadays, despite the wide availability of biological drugs and apremilast for psoriasis management, there is always a need for new therapies to customize the therapeutic approach on the basis of the patient's clinical features and comorbidities, especially in order to achieve a prolonged therapeutic response. Thus, new treatment strategies are required to offer patients a personalized approach. In this scenario, major knowledge on psoriasis pathogenesis led to the development of deucravacitinib, an orally administered selective TYK2 inhibitor.

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Congenital Disorders of Glycosylation (CDG) are rare inherited metabolic diseases caused by genetic defects in the glycosylation of proteins and lipids. In this study, we describe the generation and characterization of one human induced pluripotent stem cell (hiPSC) line from a 15-year-old male patient with CDG. The patient carried three variants, one (c.

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Gaucher disease (GD) is a rare genetic metabolic disorder characterized by a dysfunction of the lysosomal glycoside hydrolase glucocerebrosidase (GCase) due to mutations in the gene GBA1, leading to the cellular accumulation of glucosylceramide (GlcCer). While most of the current research focuses on the primary accumulated material, lesser attention has been paid to secondary storage materials and their reciprocal intertwining. By using a novel approach based on flow cytometry and fluorescent labelling, we monitored changes in storage materials directly in fibroblasts derived from GD patients carrying N370S/RecNcil and homozygous L444P or R131C mutations with respect to wild type.

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Obesity is a growing public health epidemic worldwide and is implicated in slowing improved life expectancy and increasing cardiovascular (CV) risk; indeed, several obesity-related mechanisms drive structural, functional, humoral, and hemodynamic heart alterations. On the other hand, obesity may indirectly cause CV disease, mediated through different obesity-associated comorbidities. Diet and physical activity are key points in preventing CV disease and reducing CV risk; however, these strategies alone are not always sufficient, so other approaches, such as pharmacological treatments and bariatric surgery, must support them.

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The emergence of ionotronic materials has been recently exploited for interfacing electronics and biological tissues, improving sensing with the surrounding environment. In this paper, we investigated the synergistic effect of regenerated silk fibroin (RS) with a plant-derived polyphenol (, chestnut tannin) on ionic conductivity and how water molecules play critical roles in regulating ion mobility in these materials. In particular, we observed that adding tannin to RS increases the ionic conductivity, and this phenomenon is accentuated by increasing the hydration.

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Background: Early diagnosis is essential in the field of lysosomal storage disorders for the proper management of patients and for starting therapies before irreversible damage occurs, particularly in neurodegenerative conditions. Currently, specific biomarkers for the diagnosis of lysosomal storage disorders are lacking in routine laboratory practice, except for enzymatic tests, which are available only in specialized metabolic centers. Recently, we established a method for measuring and verifying changes in GM1 ganglioside levels in peripheral blood lymphocytes in patients with GM1 gangliosidosis.

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Early events of basal cell carcinoma (BCC) tumorigenesis are triggered by inappropriate activation of SHH signaling, via the loss of () or by activating mutations of (). TBX1 is a key regulator of pharyngeal development, mainly through expression in multipotent progenitor cells of the cardiopharyngeal lineage. This transcription factor is connected to several major signaling systems, such as FGF, WNT, and SHH, and it has been linked to cell proliferation and to the regulation of cell shape and cell dynamics.

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Synopsis of recent research by authors named "Federica Feo"

  • - Federica Feo's recent research focuses on the integration of dermatology with advancements in artificial intelligence, particularly examining the potential applications of ChatGPT in the dermatological field, promoting innovation in healthcare delivery and diagnosis.
  • - She has conducted significant work on psoriasis treatment, assessing new pharmacotherapies like deucravacitinib and emphasizing the importance of personalized medicine in managing the condition while exploring ongoing clinical trials for both topical and systemic therapies.
  • - Feo is also involved in generating human induced pluripotent stem cell lines from patients with specific genetic disorders, such as GM3 synthase deficiency and congenital disorders of glycosylation, contributing to a better understanding of these rare conditions and advancing potential therapeutic approaches.