Publications by authors named "Federica Contaldo"
Article Synopsis
- Late recurrence of invasive lobular carcinoma (ILC) presents challenges in treatment, with limited understanding of its metastatic molecular landscape.
- Researchers analyzed 38 ILC patients by sequencing DNA from both primary and metastatic tissues to uncover patterns in cancer evolution and metastatic spread.
- Findings revealed varied seeding patterns and timelines for metastasis, with some patients experiencing a dormant phase and notable changes in cancer-driving genes, suggesting the need for improved ILC treatment strategies.
Background: In breast cancer (BC), axillary lymph node (ALN) involvement is one of the strongest adverse prognostic factors. However, it is unclear whether loco-regional lymph node deposits are effectively the root of secondary metastases or only an indicator of competence of the primary tumour to spread to distant organs.
Methods: Here, we investigated the evolutionary trajectories of primary tumour, ALN and distant metastasis samples from 16 estrogen-receptor (ER)-positive lymph node-positive BC patients.
Background: High levels of tumor-infiltrating lymphocytes (TILs) in primary triple negative and HER2-positive breast cancer (BC) have been associated with an improved patients' outcome. The role of TILs in Luminal (hormone receptor positive and HER2 negative) tumors remains to be elucidated. Moreover, the association between TILs and prognosis in the metastatic setting is still unknown.
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