Publications by authors named "Federica Barbugian"

Cell microenvironment contains a plethora of information that influences cell modulation. Indeed, the extracellular matrix plays a central role in tissue development. Reproducing the cell-extracellular matrix crosstalk able to recapitulate both physical and biochemical signals is crucial to obtain functional tissue models or regenerative strategies.

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Article Synopsis
  • * The study introduces a new delivery system using 150-nm liposomes to enhance the effectiveness of Givinostat, a pan-HDAC inhibitor, by improving its half-life in the bloodstream and increasing its delivery to the brain.
  • * In vitro and in vivo results showed that these liposome-Givinostat formulations effectively inhibited glioblastoma cell growth and enhanced drug delivery without causing noticeable toxicity, suggesting they hold promise for future glioblastoma therapies.
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