Publications by authors named "Federica Alberghini"
B-cell development is a multistep process sustained by a highly coordinated transcriptional network under the control of a limited set of transcription factors. Epigenetic mechanisms, including DNA methylation, histone posttranslational modifications and microRNAs act in concert with transcription factors to promote lineage commitment, define and sustain cell identity and establish heritable cell-type- and stage-specific gene expression profiles. Epigenetic modifiers have recently emerged as key regulators of B-cell development and activation.
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- B cells make antibodies to fight off germs, and they develop in special places called germinal centers (GCs).
- An important protein called EZH2 helps these B cells work properly, but it can also be linked to certain blood cancers.
- If we can control EZH2, it might help us create better treatments for diseases like lymphomas by improving how B cells function and fight infections.