Pretreatment nomogram predicting ten-year biochemical outcome of three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for prostate cancer.

Objectives: To update our previously published nomogram predicting for biochemical outcome with 10-year data from a larger cohort of patients treated with three-dimensional conformal radiotherapy (RT) or intensity-modulated RT for localized prostate cancer.

Methods: From 1988 to 2004, 2253 patients were treated with three-dimensional conformal RT or intensity-modulated RT for clinical Stage T1-T3 prostate cancer. Prescription doses ranged from 64.

Women's experiences of vaginal examinations in labour.

Objective: To investigate women's perceptions of their experiences of vaginal examinations in labour.

Design: A prospective, analytic survey design using anonymised, self-completion, postal questionnaires.

Setting: A multi-centre study conducted in 2002 in three midwifery units in Cambridgeshire, England.

Acupuncture for postchemotherapy fatigue: a phase II study.

Purpose: To determine whether improvement in postchemotherapy fatigue following acupuncture treatment is substantial enough to warrant a controlled trial.

Patients And Methods: We accrued patients at Memorial Sloan-Kettering Cancer Center who had completed cytotoxic chemotherapy but experienced persisting fatigue. Patients with severe anemia, clinical depression, or Karnofsky performance status score less than 70 were excluded.

Differential bacteriology in adenoid disease.

In order to define the differential bacteriology in adenoid disease, adenoids were obtained from 10 children with adenoid hypertrophy and 29 children with chronic adenoiditis. The patients' ages ranged from 18 months to 13 years. After removal of the adenoids, the surface organisms were destroyed by alcohol and flame disinfection.

Malignant nasopharyngeal tumors in children.

From 1964 to 1984, 25 children with malignant tumors of the nasopharynx were seen, and their progress was followed at The Hospital for Sick Children in Toronto. Two types of malignancies: rhabdomyosarcoma and lymphoepithelioma were most prevalent with eight cases apiece. The presenting signs and symptoms were related to local and/or regional manifestations of disease.

Randomized surgical adjuvant trial of interferon alfa-n1 in recurrent papillomatosis.

Sixty-six patients with recurrent respiratory papillomatosis of juvenile onset were treated for six months with interferon alfa-n1 (Wellferon) in a randomized crossover trial. Half received interferon alfa-n1 intramuscularly at a dosage of 5 megaunits per square meter daily for 28 days and then thrice weekly for five months, followed by six months of observation. The other half were observed for six months and then treated.

Interferon alfa-n1 (Wellferon) in juvenile onset recurrent respiratory papillomatosis: results of a randomized study in twelve collaborative institutions.

Sixty-six patients with clinically severe juvenile-onset recurrent respiratory papillomatosis (RRP) were entered into a 12-month randomized crossover study to evaluate interferon alpha-n1 Wellferon (WFN) as an adjuvant to CO2 laser surgical excision. Eligibility required disease onset to be before age 16, and an endoscopic excision requirement of at least three operations in the 6 months immediately prior to entry. Patients were randomized to Observation versus WFN at a dose of 5 MU/m2 daily for 28 days and three times weekly for 5 months.

Choanal atresia and associated anomalies.

The authors have studied 130 cases of choanal malformation. They found 53 bilateral atresias, 51 unilateral atresias and 26 cases of choanal stenosis. Fifty-seven of these cases were associated with other anomalies and 38 had at least two features of the CHARGE association (C, colobomas; H, heart defects; A, atresia choanae; R, retarded growth; G, genito-urinary defects; E, ear defects).

Laryngeal problems in children.

Some diseases of the larynx that now are rare were common in 1950, when the author began the practice of pediatric otolaryngology. These include laryngeal tuberculosis, bulbar poliomyelitis, and acute exanthemata. The management of laryngotracheitis and supraglottitis has altered markedly, with the mortality reduced drastically.

Traumatic bronchial injuries in children.

Between 1975 and 1981 five children (three girls and two boys) from 3 to 11 years were treated for blunt chest trauma with major tears in two areas of the right main bronchus. All were hit or run over by motor vehicles and were in acute respiratory distress. All suffered right pneumothoraces; three did not respond to a chest tube with suction.

Cricoid resection and thyrotracheal anastomosis in the growing primate.

Although many procedures have been described for the correction of subglottic stenosis in the infant and child, none has been universally satisfactory. Cricoid resection and thyrotracheal anastomosis have been successful in adults, and we considered that the same techniques could be applied to correct subglottic stenosis in infants and children. A feasibility study was undertaken using young primates as a surgical model.

Vocal cord palsy in pediatric practice: a review of 71 cases.

Seventy-one cases of vocal cord palsy were seen over a 20-year period at the Hospital for Sick Children in Toronto. Forty-four percent of the cases had a bilateral vocal cord palsy. The etiology, management and outcome of all the cases are reviewed.

Laryngeal foreign bodies in children.

Laryngeal foreign bodies (F.B.) in children are relative rare, especially in infants under one year of age, and the diagnosis and removal are difficult.

Anesthesia for laryngeal laser surgery in the infant and child.

Currently available anesthetic techniques for laryngoscopy and bronchoscopy are briefly evaluated. Recently reported complications from the literature are reviewed. Satisfactory anesthetic techniques are shown to be limited by the physical dimensions of the instruments as well as the extreme limitations of the flow capacity of the small airway itself.

Esophageal hiatal hernia in infants and children.

Although prior to 1950 esophageal hiatal hernia (EHH) in children was a seldom recognized entity, it has since then become well known. The symptoms in children are considerably different from those in adults. The cause of EHH is still somewhat in doubt.

Anesthesia and pediatric endoscopy.

An inhalation anesthetic technique applicable to all kinds of endoscopy in children is described. It provides maximum visualization for the endoscopist, permits pressurization of the airway, does not require exceptional or unusual skills, and can be successfully managed by an anesthetist utilizing universally recognized techniques of inhalation anesthesia.

Laryngeal surgery in the pediatric patient.

The primary concern in laryngeal surgery in the infant and child is to relieve airway obstruction, rather than phonation. Because airway obstruction above the larynx may stimulate or be confused with laryngeal pathology, these are described as the signs and symptoms of laryngeal disease. Although tracheotomy in the infant is frequently said to be a cause of a long-term problem, the procedure can be carried out in the smallest premature quite safely and without an extubation problem.

Treatment of subglottic hemangioma with the carbon dioxide laser.

Congenital subglottic hemangioma is a potentially life-threatening lesion usually presenting in the first three months of life. Over the years, multiple treatment modalities have been advocated. However, none has been uniformly successful, and morbidity and mortality remain high.

Orbital-facial complications of sinusitis in children.

Although complications of sinusitis in children have lessened remarkably since and advent of antibiotics, nevertheless they still occur. In a 25-year period at the Hospital for Sick Children, 6,770 patients with the diagnosis of sinusitis were reviewed and 159 of these had orbital-facial complications. Surgical intervention was necessary in 17 to prevent more serious complications.