Biomedical Information Integration via Adaptive Large Language Model Construction.

Integrating diverse biomedical knowledge information is essential to enhance the accuracy and efficiency of medical diagnoses, facilitate personalized treatment plans, and ultimately improve patient outcomes. However, Biomedical Information Integration (BII) faces significant challenges due to variations in terminology and the complex structure of entity descriptions across different datasets. A critical step in BII is biomedical entity alignment, which involves accurately identifying and matching equivalent entities across diverse datasets to ensure seamless data integration.

Role of Quercetin in DNA Repair: Possible Target to Combat Drug Resistance in Diabetes.

Diabetes Mellitus (DM) is referred to as hyperglycemia in either fasting or postprandial phases. Oxidative stress, which is defined by an excessive amount of reactive oxygen species (ROS) production, increased exposure to external stress, and an excessive amount of the cellular defense system against them, results in cellular damage. Increased DNA damage is one of the main causes of genomic instability, and genetic changes are an underlying factor in the emergence of cancer.

Amyloid-β: A potential mediator of aging-related vascular pathologies.

Aging is one of the most promising risk factors for vascular diseases, however, the precise mechanisms mediating aging-related pathologies are not fully understood. Amyloid beta (Aβ), a peptide produced by the proteolytic processing of amyloid precursor protein (APP), is known as a key mediator of brain damage involved in the pathogenesis of Alzheimer's disease (AD). Recently, it was found that the accumulation of Aβ in the vascular wall is linked to a range of aging-related vascular pathologies, indicating a potential role of Aβ in the pathogenesis of aging-associated vascular diseases.

An Adaptive Distributed Denial of Service Attack Prevention Technique in a Distributed Environment.

Cyberattacks in the modern world are sophisticated and can be undetected in a dispersed setting. In a distributed setting, DoS and DDoS attacks cause resource unavailability. This has motivated the scientific community to suggest effective approaches in distributed contexts as a means of mitigating such attacks.

Trustworthy and Reliable Deep Learning-based Cyberattack Detection in Industrial IoT.

A fundamental expectation of the stakeholders from the Industrial Internet of Things (IIoT) is its trustworthiness and sustainability to avoid the loss of human lives in performing a critical task. A trustworthy IIoT-enabled network encompasses fundamental security characteristics such as trust, privacy, security, reliability, resilience and safety. The traditional security mechanisms and procedures are insufficient to protect these networks owing to protocol differences, limited update options, and older adaptations of the security mechanisms.

Regulatory Effects of Curcumin on Platelets: An Update and Future Directions.

The rhizomatous plant turmeric, which is frequently used as a spice and coloring ingredient, yields curcumin, a bioactive compound. Curcumin inhibits platelet activation and aggregation and improves platelet count. Platelets dysfunction results in several disorders, including inflammation, atherothrombosis, and thromboembolism.

How Curcumin Targets Inflammatory Mediators in Diabetes: Therapeutic Insights and Possible Solutions.

Diabetes mellitus is a multifactorial chronic metabolic disorder, characterized by altered metabolism of macro-nutrients, such as fats, proteins, and carbohydrates. Diabetic retinopathy, diabetic cardiomyopathy, diabetic encephalopathy, diabetic periodontitis, and diabetic nephropathy are the prominent complications of diabetes. Inflammatory mediators are primarily responsible for these complications.

Computational intelligence-enabled prediction and communication mechanism for IoT-based autonomous systems.

Autonomous systems and the Internet of Things (IoT) have become more sophisticated research areas and entered successfully into various daily living activities such as smart homes & buildings, autonomous cars, drones, robots, etc. A crucial and essential aspect of these systems is the precision and accuracy of the decision-making process, i.e.

Therapeutic Role of Carotenoids in Blood Cancer: Mechanistic Insights and Therapeutic Potential.

Blood cancers are characterized by pathological disorders causing uncontrolled hematological cell division. Various strategies were previously explored for the treatment of blood cancers, including chemotherapy, Car-T therapy, targeting chimeric antigen receptors, and platelets therapy. However, all these therapies pose serious challenges that limit their use in blood cancer therapy, such as poor metabolism.

LightIoT: Lightweight and secure communication for energy-efficient IoT in health informatics.

Internet of Things (IoT) is considered as a key enabler of health informatics. IoT-enabled devices are used for in-hospital and in-home patient monitoring to collect and transfer biomedical data pertaining to blood pressure, electrocardiography (ECG), blood sugar levels, body temperature, etc. Among these devices, wearables have found their presence in a wide range of healthcare applications.

Security and Blockchain Convergence with Internet of Multimedia Things: Current Trends, Research Challenges and Future Directions.

The Internet of Multimedia Things (IoMT) orchestration enables the integration of systems, software, cloud, and smart sensors into a single platform. The IoMT deals with scalar as well as multimedia data. In these networks, sensor-embedded devices and their data face numerous challenges when it comes to security.

Pleotropic Effects of Polyphenols in Cardiovascular System.

Numerous epidemiological and clinical studies demonstrate the beneficial effects of naturally occurring, polyphenol supplementations, on cardiovascular system. The present review emphasizes on the risk factors associated with cardiovascular disorders (involving heart and blood vessels), and overview of preclinical and clinical trials on polyphenols for the treatment of cardiovascular diseases. The review collaborates PUBMED, Google Scholar and Research gate databases, which were explored using keywords and their combinations such as polyphenols, cardiovascular disease, flavonoids, atherosclerosis, cardiovascular risk factors and several others, to create an eclectic manuscript.

A Secured and Intelligent Communication Scheme for IIoT-enabled Pervasive Edge Computing.

Industrial Internet of Things (IIoT) ensures reliable and efficient data exchanges among the industrial processes using Artificial Intelligence (AI) within the cyber-physical systems. In the IIoT ecosystem, devices of industrial applications communicate with each other with little human intervention. They need to act intelligently to safeguard the data confidentiality and devices' authenticity.

A Lightweight Mutual Authentication and Privacy-preservation Scheme for Intelligent Wearable Devices in Industrial-CPS.

Industry 5.0 is the digitalization, automation and data exchange of industrial processes that involve artificial intelligence, Industrial Internet of Things (IIoT), and Industrial Cyber-Physical Systems (I-CPS). In healthcare, I-CPS enables the intelligent wearable devices to gather data from the real-world and transmit to the virtual world for decision-making.

Developing Novel Anticancer Drugs for Targeted Populations: An Update.

Background: Due to higher failure rates, lengthy time and high cost of the traditional de novo drug discovery and development process, the rate of opportunity to get new, safe and efficacious drugs for the targeted population, including pediatric patients with cancer, becomes sluggish.

Objectives: This paper discusses the development of novel anticancer drugs focusing on the identification and selection of targeted anticancer drug development for the targeted population.

Methods: Information presented in this review was obtained from different databases, including PUBMED, SCOPUS, Web of Science, and EMBASE.

Epigenetic alterations in aging tooth and the reprogramming potential.

Tooth compartments and associated supportive tissues exhibit significant alterations during aging, leading to their impaired functioning. Aging not only affects the structure and function of dental tissue but also reduces its capacity to maintain physiological homeostasis and the healing process. Decreased cementocyte viability; diminished regenerative potential of stem cells residing in the pulp, alveolar bone and periodontal ligament; and impaired osteogenic and odontogenic differentiation capacity of progenitor cells are among the cellular impacts associated with oral aging.

Cannabinoids as anti-ROS in aged pancreatic islet cells.

Aims: Cannabinoids are the chemical compounds with a high affinity for cannabinoid receptors affecting the central nervous system through the release of neurotransmitters. However, the current knowledge related to the role of such compounds in the regulation of cellular aging is limited. This study aimed to investigate the effect of cannabidiol and tetrahydrocannabinol on the function of aged pancreatic islets.

Assessment of arsenic-induced modifications in the DNA methylation of insulin-related genes in rat pancreatic islets.

Extended exposure to inorganic arsenic through contaminated drinking water has been linked with increased incidence of diabetes mellitus. The most common exposure occurs through the consumption of contaminated drinking water mainly through geogenic sources of inorganic arsenic. Epigenetic modifications are important mechanisms through which environmental pollutants could exert their toxic effects.

Targeting epigenetics in cancer: therapeutic potential of flavonoids.

Irrespective of sex and age, cancer is the leading cause of mortality around the globe. Therapeutic incompliance, unwanted effects, and economic burdens imparted by cancer treatments, are primary health challenges. The heritable features in gene expression that are propagated through cell division and contribute to cellular identity without a change in DNA sequence are considered epigenetic characteristics and agents that could interfere with these features and are regarded as potential therapeutic targets.

Ochratoxin A-induced genotoxic and epigenetic mechanisms lead to Alzheimer disease: its modulation with strategies.

Ochratoxin A (OTA) is a naturally occurring mycotoxin mostly found in food items including grains and coffee beans. It induces DNA single-strand breaks and has been considered to be carcinogenic. It is recognized as a serious threat to reproductive health both in males and females.

A Quality of Service-Aware Secured Communication Scheme for Internet of Things-Based Networks.

The Internet of Things (IoT) is an emerging technology that aims to enable the interconnection of a large number of smart devices and heterogeneous networks. Ad hoc networks play an important role in the designing of IoT-enabled platforms due to their efficient, flexible, low-cost and dynamic infrastructures. These networks utilize the available resources efficiently to maintain the Quality of Service (QoS) in a multi-hop communication.

A Review on The Protective Effects of Metformin in Sepsis-Induced Organ Failure.

Despite advances in sepsis management, it remains a major intensive-care-unit (ICU) concern. From new prospective, positive effects of metformin, such as anti-oxidant and anti-inflammatory properties are considered potentially beneficial properties for management of septic patients. This article reviewed the potential ameliorative effects of metformin in sepsis-induced organ failure.

The relationship between mercury exposure and epigenetic alterations regarding human health, risk assessment and diagnostic strategies.

Background: Exposure to the environmental toxicants poses a serious threat to human health. The extent of exposure and the development of diseases are interrelated with each other. Chronic exposure to mercury (Hg) increases the risk of developing serious human disorders from embryo to adulthood.