Publications by authors named "Fazhen Zhang"
Underrated and neglected, talaromycosis is a life-threatening fungal disease endemic to the tropical and subtropical regions of Asia. In China, it has been reported that talaromycosis mortality doubles from 24 to 50% when the diagnosis is delayed, and reaches 100% when the diagnosis is missed. Thus, the accurate diagnosis of talaromycosis is of utmost importance.
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- The study investigates the link between vitamin D deficiency, hyperglycemia, and tuberculosis (TB), proposing that DNA promoter methylation of key genes in the vitamin D metabolic pathway contributes to the susceptibility of co-existing TB and diabetes (TB-DM).
- By comparing 50 TB-DM patients with 50 healthy subjects, researchers found lower methylation levels in most candidate genes, suggesting their potential as biomarkers for diagnosing TB-DM.
- The results indicate that lower vitamin D levels correlate with decreased methylation of certain genes and an increased risk of TB-DM, highlighting the role of these genes in the disease's progression, independent of hyperglycemia.
The systemic immune-inflammation index (SII) is a novel prognostic index in various diseases. We evaluated the predictive value of SII in patients with intracerebral hemorrhage (ICH). Patients with primary spontaneous ICH were enrolled.
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