Identifying the signature of NAD+ metabolism-related genes for immunotherapy of gastric cancer.

NAD (Nicotinamide Adenine Dinucleotide) -related metabolic reprogramming in tumor cells involves multiple vital cellular processes. However, the role of NAD metabolism in immunity and the prognosis of gastric cancer (GC) remains not elucidated. Here we identified and clustered 33 NAD + metabolism-related genes (NMRGs) based on 808 GC samples from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases.

Revealing the pathogenesis of gastric intestinal metaplasia based on the mucosoid air-liquid interface.

Background: Gastric intestinal metaplasia (GIM) is an essential precancerous lesion. Although the reversal of GIM is challenging, it potentially brings a state-to-art strategy for gastric cancer therapeutics (GC). The lack of the appropriate in vitro model limits studies of GIM pathogenesis, which is the issue this work aims to address for further studies.

Enhanced LRP8 expression induced by Helicobacter pylori drives gastric cancer progression by facilitating β-Catenin nuclear translocation.

Introduction: Helicobacter pylori (H. pylori) infection has been associated with gastric carcinogenesis. However, the precise involvement of LRP8, the low-density lipoprotein receptor-related protein 8, in H.

ZNF131 facilitates the growth of hepatocellular carcinoma by acting as a transcriptional activator of SMC4 expression.

ZNF131 is a Zinc finger protein that acts as a transcription factor with oncogenic effects in multiple cancers. In this study, we aimed to explore the alternative splicing profile of ZNF131 in hepatocellular carcinoma (HCC), its regulatory effects on cell-cycle progression, and the downstream effectors. ZNF131 transcriptional profile and HCC survival analysis were conducted using data from the Cancer Genome Atlas (TCGA)-Liver Hepatocellular Cancer (LIHC) dataset.

NAD+ associated genes as potential biomarkers for predicting the prognosis of gastric cancer.

Nicotinamide adenine dinucleotide (NAD+) plays an essential role in cellular metabolism, mitochondrial homeostasis, inflammation, and senescence. However, the role of NAD+-regulated genes, including coding and long non-coding genes in cancer development is poorly understood. We constructed a prediction model based on the expression level of NAD+ metabolism-related genes (NMRGs).

Clinical implications of lncRNA LINC-PINT in cancer.

Long noncoding RNAs (lncRNAs) possess the potential for therapeutic targeting to treat many disorders, including cancers. Several RNA-based therapeutics (ASOs and small interfering RNAs) have gained FDA approval over the past decade. And with their potent effects, lncRNA-based therapeutics are of emerging significance.

Relationship Between CNVs and Immune Cells Infiltration in Gastric Tumor Microenvironment.

Gastric cancer (GC) is a highly fatal and common malignancy of the digestive system. Recent therapeutic advancements have significantly improved the clinical outcomes in GC, but due to the unavailability of suitable molecular targets, a large number of patients do not respond to the immune checkpoint inhibitors (ICI) therapy. To identify and validate potential therapeutic and prognostic targets of gastric cancer, we used the "inferCNV" R package for analyzing single-cell sequencing data (GSE112302) of GC and normal epithelial cells.

AFF3 is a novel prognostic biomarker and a potential target for immunotherapy in gastric cancer.

Background: Gastric cancer (GC) is one of the most common cancers worldwide with a poor prognosis. The tumor microenvironment (TME) serves a pivotal role in affecting the prognosis and efficacy of immunotherapy. Given the poor prognosis of GC patients and the limitation of immunotherapy, we urged to identify new prognostic and immunotherapeutic biomarkers.

Comprehensive Analysis of Colorectal Cancer Immunity and Identification of Immune-Related Prognostic Targets.

Colorectal cancer (COAD) is ranked as the third most common cancer and second in terms of cancer-related deaths worldwide. Due to its poor overall survival and prognosis, the incidents of COAD are significantly increasing. Although treatment methods have greatly been improved in the last decade, it is still not good enough to have satisfactory treatment outcomes.

Synergistic effect of the anti-PD-1 antibody with blood stable and reduction sensitive curcumin micelles on colon cancer.

Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is a potent anticancer drug with versatile biological activities, while the clinical translation of curcumin is severely limited due to its hydrophobicity, rapid elimination, and metabolism in the blood circulation. Herein, we aim to unravel the potential of curcumin as a synergistic agent with immunotherapy in the treatment of cancers. In an effort to minimize premature release and improve the systemic bioavailability, a superior blood stable and reduction sensitive curcumin micellar formulation, of which the release can be triggered by cancer cells, is rationally designed.

Screening of immunosuppressive cells from colorectal adenocarcinoma and identification of prognostic markers.

Background: Colorectal cancer (CRC) is the most common type of gastrointestinal malignant tumour. Colorectal adenocarcinoma (COAD) - the most common type of CRC - is particularly dangerous. The role of the immune system in the development of tumour-associated inflammation and cancer has received increasing attention recently.

Identification of three m6A-related mRNAs signature and risk score for the prognostication of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and is extremely harmful to human health. In recent years, N6-methyladenosine (m6A) RNA methylation in eukaryotic mRNA has been increasingly implicated in cancer pathogenesis and prognosis. In this study, we downloaded the expression profile and clinical information of 307 patients from The Cancer Genome Atlas database and 64 patients from the Gene Expression Omnibus (GEO) database, and univariate Cox analysis revealed that METTL14 was a prognostic m6A RNA methylation regulator.

Effect of oxygen supply strategy on nitrogen removal of biochar-based vertical subsurface flow constructed wetland: Intermittent aeration and tidal flow.

Insufficient dissolved oxygen (DO) concentration is recognized as one of the major factors limiting efficient nitrogen removal in constructed wetlands (CWs). This study investigated four biochar-based vertical subsurface flow constructed wetlands (VSFCWs) (system I: intermittent aeration without biochar addition; system II: intermittent aeration with biochar addition; system III: tidal flow without biochar addition; system IV: tidal flow with biochar addition) to compare the effect of oxygen supply strategies on the performance and mechanism of nitrogen removal. The results showed that NHN removal efficiencies were 85.

Dynamic analysis of self-forming dynamic membrane (SFDM) filtration in submerged anaerobic bioreactor: Performance, characteristic, and mechanism.

This study attempts to provide an improved fundamental understanding of the self-forming dynamic membrane (SFDM) filtration process in submerged anaerobic bioreactors. Excellent system performances were achieved in terms of high COD removal efficiency (∼ 90%), fast formation/reformation of SFDM (<1 h), and sustainable low-resistance (3.92 × 10 m) high-flux (10-30 L/m·h) filtration.

Mechanism of enhanced removal of quinonic intermediates during electrochemical oxidation of Orange II under ultraviolet irradiation.

The effect of ultraviolet irradiation on generation of radicals and formation of intermediates was investigated in electrochemical oxidation of the azo-dye Orange II using a TiO2-modified β-PbO2 electrode. It was found that a characteristic absorbance of quinonic compounds at 255 nm, which is responsible for the rate-determining step during aromatics degradation, was formed only in electrocatalytic oxidation. The dye can be oxidized by either HO radicals or direct electron transfer.

catena-Poly[[[diaquazinc]-bis{μ-N2,N6-bis[(pyridin-3-yl)methyl]pyridine-2,6-dicarboxamide}] dinitrate].

In the title compound, {[Zn(C(19)H(17)N(5)O(2))(2)(H(2)O)(2)](NO(3))(2)}(n), the Zn(II) cation is located at an inversion centre within a slightly distorted octahedron, ligated by four N atoms from four N(2),N(6)-bis[(pyridin-3-yl)methyl]pyridine-2,6-dicarboxamide (L) ligands occupying a plane about the Zn(II) atom with the two water O atoms perpendicular to that. In the complex molecule, the bidentate bridging L ligands display helical R and S conformers, and link the Zn(II) cations into a one-dimensional centrosymmetric double-chain structure containing 32-membered rings. The nitrate anions reside in these rings and are involved in multiple N-H.