Development of a Strategic Initiative at MD Anderson Cancer Center to Improve Outcomes in Immune-Related Adverse Events.

Immune checkpoint inhibitors (ICIs) have transformed the treatment paradigm for many cancer types. The clinical use of ICIs is increasing rapidly, including in combinations associated with increased risk of toxicities, termed "immune-related adverse events" (irAEs). Therefore, MD Anderson Cancer Center (MDACC) in Houston, Texas has proactively responded by developing a priority endeavor known as the Immuno-Oncology Toxicity (IOTOX) initiative.

Immune Profiling Mass Cytometry Assay Harmonization: Multicenter Experience from CIMAC-CIDC.

Purpose: The Cancer Immune Monitoring and Analysis Centers - Cancer Immunologic Data Commons (CIMAC-CIDC) Network is supported by the NCI to identify biomarkers of response to cancer immunotherapies across clinical trials using state-of-the-art assays. A primary platform for CIMAC-CIDC studies is cytometry by time of flight (CyTOF), performed at all CIMAC laboratories. To ensure the ability to generate comparable CyTOF data across labs, a multistep cross-site harmonization effort was undertaken.

Practitioner evaluation of an online oral health and risk assessment tool for young patients.

Aim To test the validity and acceptability of an online oral health assessment and biofeedback tool for young patients (under 17) for use in general dental practice.Methods A convenience sample of thirteen practitioners were recruited to test the functionality of a novel version of the Denplan PreViser Patient Assessment tool (DEPPA) developed for young patients (YDEPPA). Dentists who had completed eight or more assessments during a one month window were sent a link to an online feedback survey, comprising eight statements about YDEPPA, with scoring options of 0-10, where a score of 10 indicated complete agreement with the relevant questions.

Dental Management of a Patient with Multiple Idiopathic Cervical Root Resorption.

Multiple Idiopathic Cervical Root Resorption (MICRR) is a rare condition. It initiates at the cemento-enamel junction of multiple teeth. The lesions continue to grow until they unite, thereby undermining the entire coronal structure of affected teeth.

Analysis of dental care of children receiving comprehensive care under general anaesthesia at a teaching hospital in England.

Objectives: This study aimed to analyse the characteristics of comprehensive dental care provided under general anaesthesia (CDGA) and to review the additional treatment required by children over the 6 years subsequent to CDGA.

Method: Information collected from hospital records for the 6-year period following the first CDGA included the types of dental treatment performed at CDGA, the return rates for follow-up appointments, further treatment required subsequent to CDGA and the types of dental treatment performed at repeat DGA.

Results: The study population consisted of 263 children, of whom 129 had a significant medical history, with mean age of 6.

Improving oral healthcare for children--a great opportunity.

Changes in commissioning and contracting of NHS dental services will impact on oral healthcare delivery, providing new challenges and opportunities for children's oral healthcare. Now is the time to assess clinical networks and specialised services to understand how the oral healthcare needs of all children can be met appropriately and effectively so that when change comes it can be embraced for the better.

Aspects of physical and chemical alterations to proteins during food processing - some implications for nutrition.

In this paper, we give an overview of our research exploring the impact of physical and chemical processing on food proteins. There are three themes, applied to the proteins of wheat, soya, egg and dairy foods. Firstly, the impact of the Maillard reaction on food proteins is discussed, with a particular focus on how the reactions might be harnessed to manipulate food texture.

Variant Carvajal syndrome with additional dental anomalies.

Background: This paper aims to review the case of a girl who presented with a number of dental anomalies, in addition to unusual skin, nail and hair conditions. Tragically an undiagnosed cardiomyopathy caused unexpected sudden death. The case is discussed with reference to a number of dermatological and oral conditions which were considered as possible diagnoses.

An evaluation of paediatric dental general anaesthesia in Yorkshire and the Humber.

Background: Following major change in UK policy regarding dental general anaesthesia (DGA) in 2001, there appears to be little information available about paediatric DGA services, their organisation, availability and utilisation.

Aims: To establish the location, organisation and monitoring systems of paediatric DGA services in Yorkshire and the Humber Strategic Health Authority and to audit these services against existing standards of best practice.

Design: A postal survey of all potential paediatric DGA providers in Yorkshire and the Humber.

Repeat general anaesthesia, a 6-year follow up.

Objective: To investigate the number of children who subsequently required further dental general anaesthesia (DGA) following the baseline DGA for exodontia in 1997 over the next 6 year period, and identify any common factors related to these repeat DGAs.

Design: A retrospective longitudinal analysis.

Materials And Methods: Records from a UK teaching hospital for patients who had extractions under DGA within the calendar year of 1997 were identified and analysed.

UK National Clinical Guidelines in Paediatric Dentistry: stainless steel preformed crowns for primary molars.

This revised Clinical Guideline in Paediatric Dentistry replaces the previously published sixth guideline (Fayle SA. Int J Paediatr Dent 1999; 9: 311-314). The process of guideline production began in 1994, resulting in first publication in 1997.

Enamel defects and ectopic eruption in a child with Usher syndrome and a cochlear implant.

Background: Usher syndrome is a genetic disorder consisting of progressive loss of vision and hearing.

Case Report: The paper describes an 8-year-old girl with Usher syndrome type I who presented with generalized defects of the permanent dentition and ectopic eruption of the right maxillary first permanent molar. A cochlear implant had been fitted for her hearing loss, and the report reviews the implications of this device for dental treatment.

Pharmaceutical prescribing for children. Part 5. Conscious sedation for dentistry in children.

This is the fifth paper in a series on the prescribing of medicines for children by dentists working in primary dental care. It deals with conscious sedation for children.

Further dental treatment needs of children receiving exodontia under general anaesthesia at a teaching hospital in the UK.

Objectives: The aim of this study was to investigate the subsequent dental treatment needs of children who had dental extractions under general anaesthesia (GA) in 1997 in the Day Case Unit at Leeds Dental Institute (LDI), Leeds, UK, and the reasons for repeat dental GAs (DGAs).

Study Design: The authors conducted a retrospective longitudinal analysis.

Subjects And Methods: Information collected from hospital records for the 6-year period following the first DGA included: reasons for the DGA in 1997 and teeth extracted; the number of subsequent DGAs, reasons and treatment; incidents of and reasons for toothache or swelling after 1997; treatment under local anaesthesia (LA) or inhalation sedation (IS) at LDI during the 6 years following the DGA in 1997.

Teamwork in orthodontics: limiting the risks of root resorption.

Orthodontic treatment is not without risk. The risks may be due to patient factors (which may not always be evident before treatment) or may come about because of the treatment itself. While the common types of risk are well documented, less information is available as to how some of the more unusual problems can best be managed when they arise; often the need for teamwork between the patient, orthodontist and general dental practitioner (GDP) are underestimated.

A prospective clinical trial comparing preformed metal crowns and cast restorations for defective first permanent molars.

Aim: This study investigated two methods for the restoration of permanent molars affected by amelogenesis imperfecta (AI) or severe enamel defects.

Methods: A prospective clinical trial was carried out on 17 subjects affected by AI or severe enamel defects of first permanent molars. A split mouth design was used so that each right or left permanent molar in both jaws was restored using either a preformed metal crown (SSC) or a cast adhesive coping (CAC).

Molar incisor hypomineralisation: restorative management.

The methods for the restoration of permanent molars and incisors affected by Molar Incisor Hypomineralisation are reviewed. The special problems associated with restoring these teeth, such as sensitivity, occlusion and aesthetics are discussed. The various options for restoration are outlined and recommendations made as to the appropriate types of restoration.

Comparison of two methods of space prediction in the mixed dentition.

Purpose: This study compares the accuracy of space prediction for the unerupted permanent canines and premolars by a recognized method of mixed dentition space analysis (Moyers technique) vs estimation by simple visual observation (SVO).

Methods: Twenty clinicians with varying levels of dental experience and training blindly assessed study models of 4 intact arches (2 maxillary and 2 mandibular) from 3 patients in the mixed dentition using both Moyers and SVO space prediction methods. Corresponding full-mouth panoramic radiographs were available for each case.

Paediatric dentistry in the new millennium: 2. Behaviour management--helping children to accept dentistry.

Children's dentistry can be a challenge for both the patient and the dentist. The way a dentist interacts with the child patient will have a major influence on the success of any clinical or preventive care. In order to deliver high-quality dentistry to a child whilst also developing a positive attitude towards dental health, the dentist should have a good understanding of the factors that might affect the behaviour of children in the dental setting.

A clinical trial comparing the effectiveness of a three-headed versus a conventional toothbrush for oral hygiene in children.

AIM: The study was designed to compare the efficacy of the Superbrush three-headed with a conventional brush for oral hygiene in children. MATERIALS AND METHODS: The study population was 78 children attending three primary schools in Leeds (UK). The clinical trial consisted of a single blind, randomized, four visits, crossover and single use toothbrush design.