Publications by authors named "Faye M Nixon"
Article Synopsis
- Serial block face scanning electron microscopy (SBF-SEM) enables detailed 3D analysis of cells, particularly useful for studying microtubules in the mitotic spindle of human cells.
- The study highlights a new workflow that combines light microscopy with SBF-SEM to achieve improved visualization of microtubules, bridging fibers, and cellular membranes during mitosis.
- The research also introduces computational tools that analyze the spatial arrangement of microtubules and shows their sensitivity to TACC3 levels affecting microtubule order in mitotic spindles.
Kinetochore fibers (K-fibers) of the mitotic spindle are force-generating units that power chromosome movement during mitosis. K-fibers are composed of many microtubules that are held together throughout their length. Here, we show, using 3D electron microscopy, that K-fiber microtubules (MTs) are connected by a network of MT connectors.
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