The physicians quality reporting initiative: measure development, implementation and current procedural terminology coding.

The Physicians Quality Reporting Initiative (PQRI) was instituted in the latter half of 2007. PQRI is a voluntary reporting system in which the aim is to improve patient care, whereas at the same time, an eligible practitioner may receive an incentive payment for successful participation. Two pathology-specific measures were instituted in 2008; 1 for breast cancer reporting and the other for colon cancer reporting.

CENP-B is not critical for meiotic chromosome segregation in male mice.

Centromere protein B (CENP-B) is a constitutive protein that binds to a highly conserved 17bp motif located at most mammalian centromeres. To determine whether disruption of this gene affects chromosome segregation in male germ cells, we evaluated the frequencies of disomic and diploid sperm in CENP-B heterozygous and homozygous null mice using the mouse epididymal sperm aneuploidy (m-ESA) assay, a multicolor FISH method with probes for chromosomes X, Y and 8. The specificity and sensitivity of the m-ESA assay was demonstrated using Robertsonian (2.