ROS-mediated ITGB5 promotes tongue squamous cell carcinoma metastasis through epithelial mesenchymal transition and cell adhesion signal pathway.

Purpose: Integrin β5 (ITGB5) is an integrin β subunit member widely expressed in the human bodies, especially in cancer cells and tissues, which is a key factor in promoting tumor metastasis. In this study we investigated the differential expression of ITGB5 in tongue squamous cell carcinoma (TSCC), especially in those with lymph node metastasis, and revealed the possible mechanism.

Methods: The expression of ITGB5 in TSCC was analyzed by database and verified by immunohistochemistry through 135 TSCC patients' tissue sections from Sun Yat-sen Memorial Hospital and Guangzhou First People's Hospital.

Enhancing short-chain fatty acids production via acidogenic fermentation of municipal sewage sludge: Effect of sludge characteristics and peroxydisulfate pre-oxidation.

This study first employed a combined pretreatment of low-dose peroxy-disulfate (PDS) and initial pH 10 to promote short-chain fatty acids (SCFAs) production via acidogenic fermentation using different types of sewage sludge as substrates. The experimental results showed that the yield of maximal SCFAs and acetate proportion after the combined pretreatment were 1513.82 ± 28.

Promoting short-chain fatty acids production from sewage sludge via acidogenic fermentation: Optimized operation factors and iron-based persulfate activation system.

Promoting short-chain fatty acids (SCFAs) production and ensuring the stability of SCFAs-producing process are becoming the two major issues for popularizing the acidogenic fermentation (AF). The key controlling operating and influencing factors during anaerobic fermentation process were thoroughly reviewed to facilitate better process performance prediction and to optimize the process control of SCFAs promotion. The wide utilization of iron salt flocculants during wastewater treatment could result in iron accumulating in sewage sludge which influenced AF performance.