Synthesis of 9-Hydroxy-1-Benzo[]chromene Derivatives with Effective Cytotoxic Activity on MCF7/ADR, -Glycoprotein Inhibitors, Cell Cycle Arrest and Apoptosis Effects.

-Enaminonitriles bearing 9-hydroxy-1-benzo[]chromene moiety was synthesized. The targeted compounds were evaluated for their anti-proliferative activity against three human tumor cell lines, PC-3, SKOV-3 and HeLa, and the active cytotoxic compounds were further evaluated against cancer cells, MCF-7/ADR, and two normal cell lines, HFL-1 and WI-38. Few compounds were assigned to be the most potent derivatives against PC-3, SKOV-3 and HeLa cell lines in comparison with Vinblastine and Doxorubicin.

Structural Characterization and Antimicrobial Activities of 7H-Benzo[h]chromeno[2,3-d]pyrimidine and 14H-Benzo[h]chromeno[3,2-e][1,2,4]triazolo[1,5-c] pyrimidine Derivatives.

Three new series of chromene molecules have been synthesized in order to explore their antimicrobial activity. The series encompass 2-substituted 14-(4-halophenyl)-12-methoxy-14-benzo[]chromeno[3,2-][1,2,4]-triazolo[1,5-]pyrimidines -, 9-benzylideneamino-7-(4-halo-phenyl)-5-methoxy-8-imino-7-benzo-[]chromeno[2,3-]pyrimidines - and 3-ethoxycarbonyl-14-(4-halophenyl)-12-methoxy-14-benzo-[]chromeno[3,2-][1,2,4]triazolo[1,5-]pyrimidine-2-one derivatives -. The structure of these novel compounds were confirmed using IR, ¹H- and C-NMR as well as MS spectroscopy.