Differential expression of T-helper cytokines in the peritoneal fluid of women with normal ovarian cycle compared with women with chronic anovulation.

Background: Estrogen and progesterone immunoregulate the genital environment by expression of cytokines and growth factors.

Objective: To investigate the pattern of expression of T-helper cytokines during the ovarian cycle compared with women with chronic anovulation resistant to clomiphene citrate.

Hypothesis: Expression of T-helper cytokines in women with chronic anovulation may be different from the pattern in women with a normal ovarian cycle.