Publications by authors named "Favoured Baraka"
Front Immunol
November 2024
Article Synopsis
- The germinal center (GC) reaction plays a vital role in the immune response by facilitating somatic hypermutation and the selection of high-affinity B cells, making the understanding of B cell gene functions essential.
- Traditional methods for studying B cell genes, like generating knock-out mice, are complex and time-consuming, but CRISPR technology has offered a more straightforward alternative, though it still faces challenges related to cost and efficiency.
- The authors developed a new CRISPR-Cas9 method for studying B cell gene functions that is quick and cost-effective, using adoptively transferred edited B cells to investigate gene roles, exemplified by examining the pro-apoptotic gene Fas in the GC selection process.
