Publications by authors named "Fava L"

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

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  • The study investigates the processes e^{+}e^{-}→D_{s}^{+}D_{s1}(2536)^{-} and e^{+}e^{-}→D_{s}^{+}D_{s2}^{*}(2573)^{-} using data from the BESIII detector, focusing on a range of center-of-mass energies.
  • For the first time, the absolute branching fractions of the decay processes for D_{s1}(2536)^{-} and D_{s2}^{*}(2573)^{-} are measured, revealing values of 35.9% and 37.4% respectively.
  • The research identifies a resonant structure around 4.6 Ge
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Centrosomes are membrane-less organelles that orchestrate a wide array of biological functions by acting as microtubule organizing centers. Here, we report that caspase-2-driven apoptosis is elicited in blood cells failing cytokinesis and that extra centrosomes are necessary to trigger this cell death. Activation of caspase-2 depends on the PIDDosome multi-protein complex, and priming of PIDD1 at extra centrosomes is necessary for pathway activation.

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  • The RNA binding protein HuR is crucial for regulating the innate immune response, and blocking it can have positive anti-inflammatory outcomes.
  • A new series of small molecules, Tanshinone Mimics (TMs), were developed to disrupt HuR-RNA binding, with furan-containing compound 5/TM11 proving to be the most effective in inhibiting this interaction.
  • Compound 5/TM11 not only enhances solubility but also selectively decreases cell proliferation in macrophages at certain doses, leading to a significant reduction in proinflammatory cytokines in response to LPS.
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Despite major therapeutic advances in the treatment of acute lymphoblastic leukemia (ALL), resistances and long-term toxicities still pose significant challenges. Cyclins and their associated cyclin-dependent kinases are one focus of cancer research when looking for targeted therapies. We discovered cyclin C as a key factor for B-ALL development and maintenance.

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Article Synopsis
  • Scientists used special data from a detector to look for rare particle decays of a type called the D_{s}^{+} decay, focusing on how it might change into other particles like kaons or pions.
  • They found strong evidence for the decay D_{s}^{+}→π^{+}ϕ and also discovered a new decay D_{s}^{+}→ρ^{+}ϕ, both involving particles that decay into pairs of electrons.
  • However, they didn't find strong signals for three other types of decays they were looking for, and set limits on how often those changes could happen.
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  • The study investigates the J/ψ and ψ(3686) decays into Σ^{0}Σ[over ¯]^{0} processes using data from the BESIII detector, which has extensive datasets.
  • It presents the first measurements of parity-violating decay parameters for Σ^{0} and Σ[over ¯]^{0}, suggesting implications for strong CP symmetry through their asymmetries.
  • The findings include the observation of opposite transverse polarizations of Σ^{0} hyperons in these decays and the ratio of S-wave to D-wave contributions, contributing valuable insights into charmonium state dynamics.
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  • Data samples from the BESIII detector at the BEPCII collider were used to measure the Born cross sections for the e^{+}e^{-}→D^{0}D[over ¯]^{0} and D^{+}D^{-} processes with high precision.
  • Observations revealed clear peaks in the line shapes corresponding to various mass ranges, including G(3900), ψ(4040), ψ(4160), Y(4260), and ψ(4415).
  • These findings provide important experimental insights into the production of hadrons, particularly in the open-charm region.
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Using data samples collected with the BESIII detector operating at the BEPCII storage ring, the cross section of the inclusive process e^{+}e^{-}→η+X, normalized by the total cross section of e^{+}e^{-}→hadrons, is measured at eight center-of-mass energy points from 2.0000 to 3.6710 GeV.

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Using (10.087±0.044)×10^{9} J/ψ events collected with the BESIII detector at the BEPCII storage ring, the processes Λp→Λp and Λ[over ¯]p→Λ[over ¯]p are studied, where the Λ/Λ[over ¯] baryons are produced in the process J/ψ→ΛΛ[over ¯] and the protons are the hydrogen nuclei in the cooling oil of the beam pipe.

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ATP2B1 is a known regulator of calcium (Ca) cellular export and homeostasis. Diminished levels of intracellular Ca content have been suggested to impair SARS-CoV-2 replication. Here, we demonstrate that a nontoxic caloxin-derivative compound (PI-7) reduces intracellular Ca levels and impairs SARS-CoV-2 infection.

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We report the measurement of the inclusive cross sections for e^{+}e^{-}→nOCH (where nOCH denotes non-open charm hadrons) with improved precision at center-of-mass (c.m.) energies from 3.

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Based on (10087±44)×10^{6}  J/ψ events collected with the BESIII detector, a partial wave analysis of the decay J/ψ→γK_{S}^{0}K_{S}^{0}η^{'} is performed. The mass and width of the X(2370) are measured to be 2395±11(stat)_{-94}^{+26}(syst)  MeV/c^{2} and 188_{-17}^{+18}(stat)_{-33}^{+124}(syst)  MeV, respectively. The corresponding product branching fraction is B[J/ψ→γX(2370)]×B[X(2370)→f_{0}(980)η^{'}]×B[f_{0}(980)→K_{S}^{0}K_{S}^{0}]=(1.

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We present measurements of the Born cross sections for the processes e^{+}e^{-}→ωχ_{c1} and ωχ_{c2} at center-of-mass energies sqrt[s] from 4.308 to 4.951 GeV.

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Using a sample of (10087±44)×10^{6}  J/ψ events, which is about 45 times larger than that was previously analyzed, a further investigation on the J/ψ→γ3(π^{+}π^{-}) decay is performed. A significant distortion at 1.84  GeV/c^{2} in the line shape of the 3(π^{+}π^{-}) invariant mass spectrum is observed for the first time, which could be resolved by two overlapping resonant structures, X(1840) and X(1880).

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We perform a study of the χ_{c1}(3872) line shape using the data samples of e^{+}e^{-}→γχ_{c1}(3872), χ_{c1}(3872)→D^{0}D[over ¯]^{0}π^{0}, and π^{+}π^{-}J/ψ collected with the BESIII detector. The effects of the coupled channels and the off-shell D^{*0} are included in the parametrization of the line shape. The line shape mass parameter is obtained to be M_{X}=(3871.

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Using e^{+}e^{-} collision data corresponding to an integrated luminosity of 7.33  fb^{-1} recorded by the BESIII detector at center-of-mass energies between 4.128 and 4.

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We perform for the first time an amplitude analysis of the decay D^{+}→K_{S}^{0}π^{+}η and report the observation of the decay D^{+}→K_{S}^{0}a_{0}(980)^{+} using 2.93  fb^{-1} of e^{+}e^{-} collision data taken at a center-of-mass energy of 3.773 GeV with the BESIII detector.

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We present cross sections for the reaction e^{+}e^{-}→K_{S}^{0}K_{L}^{0} at center-of-mass energies ranging from 3.51 to 4.95 GeV using data samples collected in the BESIII experiment, corresponding to a total integrated luminosity of 26.

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Using (10087±44)×10^{6}  J/ψ events collected with the BESIII detector, numerous Ξ^{-} and Λ decay asymmetry parameters are simultaneously determined from the process J/ψ→Ξ^{-}Ξ[over ¯]^{+}→Λ(pπ^{-})π^{-}Λ[over ¯](n[over ¯]π^{0})π^{+} and its charge-conjugate channel. The precisions of α_{Λ0} for Λ→nπ^{0} and α[over ¯]_{Λ0} for Λ[over ¯]→n[over ¯]π^{0} compared to world averages are improved by factors of 4 and 1.7, respectively.

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Based on data samples collected with the BESIII detector at the BEPCII collider, the process e^{+}e^{-}→Σ^{+}Σ[over ¯]^{-} is studied at center-of-mass energies sqrt[s]=2.3960, 2.6454, and 2.

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Based on 4.4  fb^{-1} of e^{+}e^{-} annihilation data collected at the center-of-mass energies between 4.60 and 4.

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The adoption of advanced artificial intelligence (AI) systems in healthcare is transforming the healthcare-delivery landscape. Artificial intelligence may enhance patient safety and improve healthcare outcomes, but it presents notable ethical and legal dilemmas. Moreover, as AI streamlines the analysis of the multitude of factors relevant to malpractice claims, including informed consent, adherence to standards of care, and causation, the evaluation of professional liability might also benefit from its use.

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Using data samples with an integrated luminosity of 5.85  fb^{-1} collected at center-of-mass energies from 4.61 to 4.

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