Isolation of new lucilactaene derivatives from P450 monooxygenase and aldehyde dehydrogenase knockout Fusarium sp. RK97-94 strains and their biological activities.

Fusarium sp. RK97-94 is a producer of potent antimalarial compounds such as lucilactaene and its derivatives. The biosynthetic gene cluster of lucilactaene was identified but only a knockout mutant of methyltransferase (luc1) was reported in previous papers.

Bioactivities and Mode of Actions of Dibutyl Phthalates and Nocardamine from sp. H11809.

Dibutyl phthalate (DBP) produced by sp. H11809 exerted inhibitory activity against human GSK-3β ( GSK-3β) and 3D7 ( 3D7) malaria parasites. The current study aimed to determine DBP's plausible mode of action against GSK-3β and 3D7.

Draft genome sequence data of sp. FH025.

The genome data of sp. FH025 comprised of 8,381,474 bp with a high GC content of 72.51%.

Anti-malarial Activities of Two Soil Actinomycete Isolates from Sabah via Inhibition of Glycogen Synthase Kinase 3β.

Exploiting natural resources for bioactive compounds is an attractive drug discovery strategy in search for new anti-malarial drugs with novel modes of action. Initial screening efforts in our laboratory revealed two preparations of soil-derived actinomycetes (H11809 and FH025) with potent anti-malarial activities. Both crude extracts showed glycogen synthase kinase 3β (GSK3β)-inhibitory activities in a yeast-based kinase assay.