Pharmaco-epidemiological evaluation of veterinary antimicrobial prescriptions for cattle, swine, small ruminants, poultry, rainbow trout, and food-producing horses in Umbria in 2014.

Veterinary  antimicrobial  use  could  lead  to  problems  such  as  the  spread  of  antimicrobial resistance or the presence of residues in animal-derived products for human consumption. Related  to  this,  data  on  drug  consumption  is  in  strong  demand.  The  aims  of  this  study are  therefore  to  evaluate  a  regional  Defined  Daily  Dose  (DDDvet_Umbria)  for  all  of  the antimicrobials  prescribed  in  Umbria  during  2014  and  to  analyse  prescriptions  for  cattle, swine,  small  ruminants,  poultry,  rainbow  trout,  and  food-producing  horses.

Evaluation of antibiotic usage in swine reproduction farms in Umbria region based on the quantitative analysis of antimicrobial consumption.

Antibiotic use in food-producing animals has considerable impact on public health, especially with respect to the development and spread of antibiotic resistance. Pigs represent one of the main species in which antibiotics are frequently used for different purposes. Surveillance of antibiotic consumption and dose appropriateness, through novel approaches based on , is strongly needed to assess farms' antibiotic risk, in terms of spread of antibiotic resistance and possibile presence of residues in meat.

Ovine subclinical mastitis: proteomic analysis of whey and milk fat globules unveils putative diagnostic biomarkers in milk.

Unlabelled: Subclinical mastitis is one of the main causes of alteration in milk content and has a major impact on both animal welfare and economy in the dairy industry. A better knowledge is needed to understand the ovine mammary gland metabolism and its response to bacterial infection. In this study, the proteomic changes in ovine milk as a result of subclinical mastitis were investigated by comparing both whey and fat globule membrane profiles of samples from Staphylococcus chromogenes-positive individuals, with those from non-infected counterparts having high or low somatic cell count; the latter were used as control.

Proteomic evaluation of sheep serum proteins.

Background: The applications of proteomic strategies to ovine medicine remain limited. The definition of serum proteome may be a good tool to identify useful protein biomarkers for recognising sub-clinical conditions and overt disease in sheep. Findings from bovine species are often directly translated for use in ovine medicine.

Plasma protein changes in horse after prolonged physical exercise: a proteomic study.

Physical exercise induces various stress responses and metabolic adaptations that have not yet been completely elucidated. Novel biomarkers are needed in sport veterinary medicine to monitor training levels and to detect subclinical conditions that can develop into exercise-related diseases. In this study, protein modifications in horse plasma induced by prolonged, aerobic physical exercise were investigated by using a proteomic approach based on 2-DE and combined mass spectrometry procedures.

Gambling on putative biomarkers of osteoarthritis and osteochondrosis by equine synovial fluid proteomics.

Osteoarthritis (OA) and osteochondrosis (OC) are two of the main challenges in orthopedics, whose definitive diagnosis is usually based on radiographic/arthroscopic evidences. Their early diagnosis should allow preventive or timely therapeutic actions, which are generally precluded from the poor relationships occurring between symptomatologic and radiographic evidences. These limitations should be overcome by improving the knowledge on articular tissue metabolism and on molecular factors regulating its normal homeostasis, also identifying novel OA and OC biomarkers suitable for their earlier diagnoses, whenever clinical/pathological inflammatory scenarios between these joint diseases seem somewhat related.