Accelerometer-Assisted Physical Activity Outcomes During the First Year of Recovery After Anterior Cruciate Ligament Reconstruction: A Prospective Cohort Pilot Study.

Background: Wearable activity-measurement devices are increasingly popular among the public, but there is little information regarding their use among patients undergoing sports medicine procedures. The purpose of this study was to compare accelerometer-measured data with traditional patient-reported measures and to determine the trajectory of physical activity from before surgery to 1 year after anterior cruciate ligament reconstruction.

Materials And Methods: Adult patients undergoing primary anterior cruciate ligament reconstruction were enrolled in this prospective cohort pilot study.

An umbrella review and meta-analysis of 87 meta-analyses examining healthcare workers' mental health during the COVID-19 pandemic.

During the COVID-19 pandemic, healthcare workers (HCWs) experienced several changes in their work (e.g., longer hours, new policies) that affected their mental health.

Tracking Physical Activity and Nutrition Policies and Practices in Early Childhood Education and Care: Five Years Post-Implementation of a Provincial-Level Active Play Standard.

Early childhood education and care (ECEC) settings are key for improving health behaviors, including physical activity (PA) and nutrition. In 2017, the province of British Columbia (BC) implemented a provincial-level Active Play policy supported by a capacity-building intervention. Significant improvements in all PA policies and practices and the majority of nutrition policies were observed post-implementation.

Exploring the Influence of Interorganization Networks on the Dissemination of National Health Behavior Guidelines.

Background: Interorganization partnerships are important for the development and knowledge mobilization of national health behavior guidelines. However, little is known about how to improve the dissemination of guidelines across professional networks. Social network analysis may offer unique insight into the social structure of interorganization networks and provide guidance for how network features may be harnessed for effective dissemination.

A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia.

Unlabelled: is one of the three most frequently mutated genes in age-related clonal hematopoiesis (CH), alongside and . CH can progress to myeloid malignancies including chronic monomyelocytic leukemia (CMML), and is also strongly associated with inflammatory cardiovascular disease and all-cause mortality in humans. DNMT3A and TET2 regulate DNA methylation and demethylation pathways respectively, and loss-of-function mutations in these genes reduce DNA methylation in heterochromatin, allowing de-repression of silenced elements in heterochromatin.

A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia.

is one of the three most frequently mutated genes in age-related clonal hematopoiesis (CH), alongside and (. CH can progress to myeloid malignancies including chronic monomyelocytic leukemia (CMML) and is also strongly associated with inflammatory cardiovascular disease and all-cause mortality in humans. DNMT3A and TET2 regulate DNA methylation and demethylation pathways, respectively, and loss-of-function mutations in these genes reduce DNA methylation in heterochromatin, allowing derepression of silenced elements in heterochromatin.

Chromatin-based memory as a self-stabilizing influence on cell identity.

Cell types are traditionally thought to be specified and stabilized by gene regulatory networks. Here, we explore how chromatin memory contributes to the specification and stabilization of cell states. Through pervasive, local, feedback loops, chromatin memory enables cell states that were initially unstable to become stable.

Barriers and facilitators to the dissemination of national movement behavior guidelines among health-promoting organizations: a qualitative study.

Background: National movement behavior guidelines offer evidence-informed recommendations for how to obtain health benefits. However, their impact on practice and policy has been limited. Factors at multiple levels determine the effective mobilization of knowledge into practice.

Are Experiences of Discrimination Associated With Views of Physical Activity and Climate Policy Support in Canada?

Background: Social climate refers to the general feelings, norms, and opinions in a society and may be affected by experiences of discrimination. This study examined whether experiences of discrimination are associated with the social climate of physical (in)activity and support for policies addressing dual benefits of physical activity (PA) and climate change.

Methods: Data from the 2023 Social Climate Survey were used (n = 1950; ≥18 y).

Reallocating time between movement behaviors has implications for post-secondary students' mental health and wellbeing.

: Examine the theoretical impact of reallocating time between self-reported moderate-to-vigorous physical activity (MVPA), recreational screen time, and sleep on psychological distress and mental wellbeing among post-secondary students. : 24,742 post-secondary students (=24.3 ± 7.

The relevance of the United Nations' Sustainable Development Goals in the promotion of sport, physical activity, and recreation in Canada.

Canada is unique in that it has established four national strategies in support of sport, physical activity, and/or recreation (SPAR). Though some of these strategies identify potential social and environmental correlates of SPAR, and articulate societal outcomes such as changes in behaviour and health, there are no explicit links to larger global initiatives such as the United Nations' Sustainable Development Goals (SDGs). Given that countries are expected to propose a plan for addressing the 17 SDGs, and that obvious overlap exists between several of the proposed development goals and SPAR, Canada should consider whether common indicators can be identified across these strategies and the SDGs simultaneously to facilitate more efficient and effective action.

Inequities in sleep duration and quality among adolescents in Canada.

Background: Several recent global events may have impacted adolescent sleep and exacerbated pre-existing disparities by social positions (i.e., social roles, identity or sociodemographic factors, and/or group memberships that are associated with power and oppression due to the structures and processes in a given society at given time).

An online delivered running and walking group program to support low-active post-secondary students' well-being and exercise behavior during the COVID-19 pandemic: a pilot randomized controlled trial.

Objective: Examine the feasibility and acceptability of a social identity-informed, online delivered, running and walking group program to support low-active post-secondary students' exercise behavior and well-being during the COVID-19 pandemic.

Methods: A two-arm, non-blinded, parallel pilot randomized controlled trial was conducted whereby low-active post-secondary students at a Canadian university were equally randomized to an online delivered running/walking group program or an attention control condition. Primary feasibility and acceptability outcomes included program interest, study enrolment and retention, questionnaire completion, program attendance, program satisfaction, and affective exercise attitudes.

Development and evaluation of the Capability, Opportunity, and Motivation to deliver Physical Activity in School Scale (COM-PASS).

Background: Teachers are recognized as 'key agents' for the delivery of physical activity programs and policies in schools. The aim of our study was to develop and evaluate a tool to assess teachers' capability, opportunity, and motivation to deliver school-based physical activity interventions.

Methods: The development and evaluation of the Capability, Opportunity, and Motivation to deliver Physical Activity in School Scale (COM-PASS) involved three phases.

Biopsychosocial and Environmental Correlates of Children's Motor Competence: An Exploratory Study.

Background: Given the significance of motor competence (MC) for healthy development and as a cornerstone for lifelong physical activity (PA), it is crucial to understand the manifold factors that are associated with MC. Thus, the aim of the present study was to investigate correlates of children's MC and their fundamental movement skills (FMS) within their daily life from a comprehensive biopsychosocial-ecological perspective.

Methods: This is a cross-sectional sub-study of the 'Physical Literacy for Communities (PL4C)' WAVES cohort study conducted in the West Vancouver School District, Canada.

"Losing access to outdoor spaces was the biggest challenge for children to be healthy": pandemic restrictions and community supports for children's movement in Nova Scotia.

Introduction: Health-focused communities can promote physical activity for children by providing them with safe and supportive environments to move. Across the COVID-19 pandemic many community spaces and services were closed due to public health restrictions. During the pandemic, Atlantic Canada uniquely implemented an agreement between four provinces to restrict travel and reduce the spread of the virus.

Two HUSH complexes connect a direct LINE to innate immunity.

In this issue of Molecular Cell, Danac et al. identify a second HUSH complex, HUSH2, that represses interferon-stimulated genes and, by competing for subunits with the canonical HUSH complex, couples LINE-1 (L1) retrotransposon transcription with immune activation.

Acute effects of outdoor versus indoor exercise: a systematic review and meta-analysis.

Exercise and nature exposure are independently recognised for their positive relationship with health, but their combined effects are not fully understood. The present review summarises the evidence that compares physiological and perceptual differences of a single bout of exercise performed outdoors versus indoors. Nine databases were searched for articles published before March 2021 which utilised controlled designs to assess at least one physiological outcome during or after a single acute bout of outdoor exercise.

Psychological distress among Canadian postsecondary students: a repeated cross-sectional analysis of the Canadian Campus Wellbeing Survey (CCWS) between spring 2020-2023.

: To examine trends in self-reported psychological distress among Canadian postsecondary students between 2020 and 2023. : Using data collected from postsecondary students ( = 103,936) through the Canadian Campus Wellbeing Survey (CCWS), multilevel regression models were fitted to determine how distress levels, as measured by the Kessler Psychological Distress Scale, differed across six-time points of the CCWS. Across the cycles, students reported high levels of distress (mean across cycles = 26.

Patient Satisfaction With Long-term Sacral Neuromodulation for Fecal Incontinence: Experience From a Single Tertiary Center.

Background: Sacral neuromodulation is an effective treatment for fecal incontinence in the long term. Efficacy is typically assessed using bowel diary, symptom severity, and quality-of-life questionnaires, and "success" is defined as more than 50% improvement in these measures. However, patient satisfaction may be a more meaningful and individualized measure of treatment efficacy.

LINE-1 retrotransposons contribute to mouse PV interneuron development.

Retrotransposons are mobile DNA sequences duplicated via transcription and reverse transcription of an RNA intermediate. Cis-regulatory elements encoded by retrotransposons can also promote the transcription of adjacent genes. Somatic LINE-1 (L1) retrotransposon insertions have been detected in mammalian neurons.

Comparative cofactor screens show the influence of transactivation domains and core promoters on the mechanisms of transcription.

Eukaryotic transcription factors (TFs) activate gene expression by recruiting cofactors to promoters. However, the relationships between TFs, promoters and their associated cofactors remain poorly understood. Here we combine GAL4-transactivation assays with comparative CRISPR-Cas9 screens to identify the cofactors used by nine different TFs and core promoters in human cells.